Cytotoxicity evaluation and apoptosis-inducing effects of furanone analogues in insect cell line SL2

Insecticides containing furan ring have attracted more attention owing to their unique mechanism of action. 25 furanone analogues were used to conduct a preliminary screening on insect cell line SL2 and these compounds exhibited good cytoactivity. Particularly, compound 14 presented good inhibitory...

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Autores principales:	Yuanhang Ren, Liqin He, Hong Jin, Ke Tao, Taiping Hou
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2018
Materias:	furanone analogues sl2 cell cytotoxicity evaluation apoptosis Agriculture (General) S1-972 Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/2d4d1a8a93b0402797f77ec30b79d6f7
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spelling	oai:doaj.org-article:2d4d1a8a93b0402797f77ec30b79d6f72021-11-26T11:19:46ZCytotoxicity evaluation and apoptosis-inducing effects of furanone analogues in insect cell line SL20954-01051465-344310.1080/09540105.2018.1491531https://doaj.org/article/2d4d1a8a93b0402797f77ec30b79d6f72018-01-01T00:00:00Zhttp://dx.doi.org/10.1080/09540105.2018.1491531https://doaj.org/toc/0954-0105https://doaj.org/toc/1465-3443Insecticides containing furan ring have attracted more attention owing to their unique mechanism of action. 25 furanone analogues were used to conduct a preliminary screening on insect cell line SL2 and these compounds exhibited good cytoactivity. Particularly, compound 14 presented good inhibitory effect with an IC50 value of 28.14 μM. Subsequently, we investigated the selectivity against insect cells by testing the cytotoxicity of it on human cell line HEK293 and we noticed that compound 14 was less toxicity than the reference insect cells. Finally, we attempted to illustrate the act mechanism of compound 14 on SL2 cells at the cellular level and found it initiated apoptosis through a caspase-dependent mitochondrial pathway that down-regulated mitochondrial membrane potential level, increased the activity of caspase-3 and altered the cell cycle. The result showed that compound 14 could be considered as a new potent insecticide to be used for further optimization.Yuanhang RenLiqin HeHong JinKe TaoTaiping HouTaylor & Francis Grouparticlefuranone analoguessl2 cellcytotoxicity evaluationapoptosisAgriculture (General)S1-972Immunologic diseases. AllergyRC581-607ENFood and Agricultural Immunology, Vol 29, Iss 1, Pp 964-975 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	furanone analogues sl2 cell cytotoxicity evaluation apoptosis Agriculture (General) S1-972 Immunologic diseases. Allergy RC581-607
spellingShingle	furanone analogues sl2 cell cytotoxicity evaluation apoptosis Agriculture (General) S1-972 Immunologic diseases. Allergy RC581-607 Yuanhang Ren Liqin He Hong Jin Ke Tao Taiping Hou Cytotoxicity evaluation and apoptosis-inducing effects of furanone analogues in insect cell line SL2
description	Insecticides containing furan ring have attracted more attention owing to their unique mechanism of action. 25 furanone analogues were used to conduct a preliminary screening on insect cell line SL2 and these compounds exhibited good cytoactivity. Particularly, compound 14 presented good inhibitory effect with an IC50 value of 28.14 μM. Subsequently, we investigated the selectivity against insect cells by testing the cytotoxicity of it on human cell line HEK293 and we noticed that compound 14 was less toxicity than the reference insect cells. Finally, we attempted to illustrate the act mechanism of compound 14 on SL2 cells at the cellular level and found it initiated apoptosis through a caspase-dependent mitochondrial pathway that down-regulated mitochondrial membrane potential level, increased the activity of caspase-3 and altered the cell cycle. The result showed that compound 14 could be considered as a new potent insecticide to be used for further optimization.
format	article
author	Yuanhang Ren Liqin He Hong Jin Ke Tao Taiping Hou
author_facet	Yuanhang Ren Liqin He Hong Jin Ke Tao Taiping Hou
author_sort	Yuanhang Ren
title	Cytotoxicity evaluation and apoptosis-inducing effects of furanone analogues in insect cell line SL2
title_short	Cytotoxicity evaluation and apoptosis-inducing effects of furanone analogues in insect cell line SL2
title_full	Cytotoxicity evaluation and apoptosis-inducing effects of furanone analogues in insect cell line SL2
title_fullStr	Cytotoxicity evaluation and apoptosis-inducing effects of furanone analogues in insect cell line SL2
title_full_unstemmed	Cytotoxicity evaluation and apoptosis-inducing effects of furanone analogues in insect cell line SL2
title_sort	cytotoxicity evaluation and apoptosis-inducing effects of furanone analogues in insect cell line sl2
publisher	Taylor & Francis Group
publishDate	2018
url	https://doaj.org/article/2d4d1a8a93b0402797f77ec30b79d6f7
work_keys_str_mv	AT yuanhangren cytotoxicityevaluationandapoptosisinducingeffectsoffuranoneanaloguesininsectcelllinesl2 AT liqinhe cytotoxicityevaluationandapoptosisinducingeffectsoffuranoneanaloguesininsectcelllinesl2 AT hongjin cytotoxicityevaluationandapoptosisinducingeffectsoffuranoneanaloguesininsectcelllinesl2 AT ketao cytotoxicityevaluationandapoptosisinducingeffectsoffuranoneanaloguesininsectcelllinesl2 AT taipinghou cytotoxicityevaluationandapoptosisinducingeffectsoffuranoneanaloguesininsectcelllinesl2
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Cytotoxicity evaluation and apoptosis-inducing effects of furanone analogues in insect cell line SL2

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