Locomotor deficits in a mouse model of ALS are paralleled by loss of V1-interneuron connections onto fast motor neurons

Here the authors show in a model of ALS that motor neurons receive stronger inhibitory synaptic inputs than slow motor neurons, and disease progression is associated with specific loss of inhibitory synapses onto fast motor neurons.

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Autores principales:	Ilary Allodi, Roser Montañana-Rosell, Raghavendra Selvan, Peter Löw, Ole Kiehn
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2d524ec808c645ff969f21c21afd1cea
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spelling	oai:doaj.org-article:2d524ec808c645ff969f21c21afd1cea2021-12-02T15:03:03ZLocomotor deficits in a mouse model of ALS are paralleled by loss of V1-interneuron connections onto fast motor neurons10.1038/s41467-021-23224-72041-1723https://doaj.org/article/2d524ec808c645ff969f21c21afd1cea2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23224-7https://doaj.org/toc/2041-1723Here the authors show in a model of ALS that motor neurons receive stronger inhibitory synaptic inputs than slow motor neurons, and disease progression is associated with specific loss of inhibitory synapses onto fast motor neurons.Ilary AllodiRoser Montañana-RosellRaghavendra SelvanPeter LöwOle KiehnNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ilary Allodi Roser Montañana-Rosell Raghavendra Selvan Peter Löw Ole Kiehn Locomotor deficits in a mouse model of ALS are paralleled by loss of V1-interneuron connections onto fast motor neurons
description	Here the authors show in a model of ALS that motor neurons receive stronger inhibitory synaptic inputs than slow motor neurons, and disease progression is associated with specific loss of inhibitory synapses onto fast motor neurons.
format	article
author	Ilary Allodi Roser Montañana-Rosell Raghavendra Selvan Peter Löw Ole Kiehn
author_facet	Ilary Allodi Roser Montañana-Rosell Raghavendra Selvan Peter Löw Ole Kiehn
author_sort	Ilary Allodi
title	Locomotor deficits in a mouse model of ALS are paralleled by loss of V1-interneuron connections onto fast motor neurons
title_short	Locomotor deficits in a mouse model of ALS are paralleled by loss of V1-interneuron connections onto fast motor neurons
title_full	Locomotor deficits in a mouse model of ALS are paralleled by loss of V1-interneuron connections onto fast motor neurons
title_fullStr	Locomotor deficits in a mouse model of ALS are paralleled by loss of V1-interneuron connections onto fast motor neurons
title_full_unstemmed	Locomotor deficits in a mouse model of ALS are paralleled by loss of V1-interneuron connections onto fast motor neurons
title_sort	locomotor deficits in a mouse model of als are paralleled by loss of v1-interneuron connections onto fast motor neurons
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/2d524ec808c645ff969f21c21afd1cea
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Locomotor deficits in a mouse model of ALS are paralleled by loss of V1-interneuron connections onto fast motor neurons

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