African-centric TP53 variant increases iron accumulation and bacterial pathogenesis but improves response to malaria toxin

African-centric TP53 variant increases iron accumulation and bacterial pathogenesis but improves response to malaria toxin

A polymorphism in human TP53 (P47S) that predominantly exists in individuals of African descent affects ferroptosis. Here, the authors show that this results in iron accumulation in macrophages leading to more productive infection by intracellular bacteria but improved anti-inflammatory response to...

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Autores principales: Kumar Sachin Singh, Julia I-Ju Leu, Thibaut Barnoud, Prashanthi Vonteddu, Keerthana Gnanapradeepan, Cindy Lin, Qin Liu, James C. Barton, Andrew V. Kossenkov, Donna L. George, Maureen E. Murphy, Farokh Dotiwala
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Science
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Acceso en línea:https://doaj.org/article/2d5a574431c94fcbb245e3571e64248d
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Sumario:A polymorphism in human TP53 (P47S) that predominantly exists in individuals of African descent affects ferroptosis. Here, the authors show that this results in iron accumulation in macrophages leading to more productive infection by intracellular bacteria but improved anti-inflammatory response to the malarial toxin hemozoin.

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