African-centric TP53 variant increases iron accumulation and bacterial pathogenesis but improves response to malaria toxin

A polymorphism in human TP53 (P47S) that predominantly exists in individuals of African descent affects ferroptosis. Here, the authors show that this results in iron accumulation in macrophages leading to more productive infection by intracellular bacteria but improved anti-inflammatory response to...

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Autores principales:	Kumar Sachin Singh, Julia I-Ju Leu, Thibaut Barnoud, Prashanthi Vonteddu, Keerthana Gnanapradeepan, Cindy Lin, Qin Liu, James C. Barton, Andrew V. Kossenkov, Donna L. George, Maureen E. Murphy, Farokh Dotiwala
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2d5a574431c94fcbb245e3571e64248d
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spelling	oai:doaj.org-article:2d5a574431c94fcbb245e3571e64248d2021-12-02T17:33:00ZAfrican-centric TP53 variant increases iron accumulation and bacterial pathogenesis but improves response to malaria toxin10.1038/s41467-019-14151-92041-1723https://doaj.org/article/2d5a574431c94fcbb245e3571e64248d2020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-14151-9https://doaj.org/toc/2041-1723A polymorphism in human TP53 (P47S) that predominantly exists in individuals of African descent affects ferroptosis. Here, the authors show that this results in iron accumulation in macrophages leading to more productive infection by intracellular bacteria but improved anti-inflammatory response to the malarial toxin hemozoin.Kumar Sachin SinghJulia I-Ju LeuThibaut BarnoudPrashanthi VontedduKeerthana GnanapradeepanCindy LinQin LiuJames C. BartonAndrew V. KossenkovDonna L. GeorgeMaureen E. MurphyFarokh DotiwalaNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kumar Sachin Singh Julia I-Ju Leu Thibaut Barnoud Prashanthi Vonteddu Keerthana Gnanapradeepan Cindy Lin Qin Liu James C. Barton Andrew V. Kossenkov Donna L. George Maureen E. Murphy Farokh Dotiwala African-centric TP53 variant increases iron accumulation and bacterial pathogenesis but improves response to malaria toxin
description	A polymorphism in human TP53 (P47S) that predominantly exists in individuals of African descent affects ferroptosis. Here, the authors show that this results in iron accumulation in macrophages leading to more productive infection by intracellular bacteria but improved anti-inflammatory response to the malarial toxin hemozoin.
format	article
author	Kumar Sachin Singh Julia I-Ju Leu Thibaut Barnoud Prashanthi Vonteddu Keerthana Gnanapradeepan Cindy Lin Qin Liu James C. Barton Andrew V. Kossenkov Donna L. George Maureen E. Murphy Farokh Dotiwala
author_facet	Kumar Sachin Singh Julia I-Ju Leu Thibaut Barnoud Prashanthi Vonteddu Keerthana Gnanapradeepan Cindy Lin Qin Liu James C. Barton Andrew V. Kossenkov Donna L. George Maureen E. Murphy Farokh Dotiwala
author_sort	Kumar Sachin Singh
title	African-centric TP53 variant increases iron accumulation and bacterial pathogenesis but improves response to malaria toxin
title_short	African-centric TP53 variant increases iron accumulation and bacterial pathogenesis but improves response to malaria toxin
title_full	African-centric TP53 variant increases iron accumulation and bacterial pathogenesis but improves response to malaria toxin
title_fullStr	African-centric TP53 variant increases iron accumulation and bacterial pathogenesis but improves response to malaria toxin
title_full_unstemmed	African-centric TP53 variant increases iron accumulation and bacterial pathogenesis but improves response to malaria toxin
title_sort	african-centric tp53 variant increases iron accumulation and bacterial pathogenesis but improves response to malaria toxin
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/2d5a574431c94fcbb245e3571e64248d
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African-centric TP53 variant increases iron accumulation and bacterial pathogenesis but improves response to malaria toxin

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