State and trait of finger tapping performance in multiple sclerosis

Abstract Finger tapping tests have been shown feasible to assess motor performance in multiple sclerosis (MS) and were observed to be strongly associated with the estimated clinical severity of the disease. Therefore, tapping tests could be an adequate tool to assess disease status in MS. In this st...

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Autores principales:	Philipp Gulde, Heike Vojta, Joachim Hermsdörfer, Peter Rieckmann
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2d5acb2849b046c1a85371f084e2e3b8
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spelling	oai:doaj.org-article:2d5acb2849b046c1a85371f084e2e3b82021-12-02T16:34:58ZState and trait of finger tapping performance in multiple sclerosis10.1038/s41598-021-96485-32045-2322https://doaj.org/article/2d5acb2849b046c1a85371f084e2e3b82021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-96485-3https://doaj.org/toc/2045-2322Abstract Finger tapping tests have been shown feasible to assess motor performance in multiple sclerosis (MS) and were observed to be strongly associated with the estimated clinical severity of the disease. Therefore, tapping tests could be an adequate tool to assess disease status in MS. In this study we examined potential influencing factors on a maximum tapping task with the whole upper-limb for 10 s in 40 MS patients using linear mixed effects modelling. Patients were tested in three sessions with two trials per body-side per session over the course of 4–27 days of inpatient rehabilitation. Tested factors were the expanded disability scale (EDSS) score, laterality of MS, age, sex, hand dominance, time of day, session, trial (first or second), time between sessions, and the reported day form. A second model used these factors to examine the self-reported day form of patients. Linear mixed effects modelling indicated the tapping test to have a good inter-trial (proportional variance < 0.01) and inter-session reliability (non-significant; when controlling for time between sessions), an influence of hand-dominance (proportional variance 0.08), to be strongly associated with the EDSS (eta2 = 0.22, interaction with laterality of MS eta2 = 0.12) and to be not associated with the reported day form. The model explained 87% (p < 0.01) of variance in tapping performance. Lastly, we were able to observe a positive effect of neurologic inpatient rehabilitation on task performance obvious from a significant effect of the time between sessions (eta2 = 0.007; longer time spans between sessions were associated with higher increments in performance). Day form was only impacted by EDSS and the time of the day (p < 0.01, R2 = 0.57, eta2 TIME = 0.017, eta2 EDSS = 01.19). We conclude that the tapping test is a reliable and valid assessment tool for MS.Philipp GuldeHeike VojtaJoachim HermsdörferPeter RieckmannNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Philipp Gulde Heike Vojta Joachim Hermsdörfer Peter Rieckmann State and trait of finger tapping performance in multiple sclerosis
description	Abstract Finger tapping tests have been shown feasible to assess motor performance in multiple sclerosis (MS) and were observed to be strongly associated with the estimated clinical severity of the disease. Therefore, tapping tests could be an adequate tool to assess disease status in MS. In this study we examined potential influencing factors on a maximum tapping task with the whole upper-limb for 10 s in 40 MS patients using linear mixed effects modelling. Patients were tested in three sessions with two trials per body-side per session over the course of 4–27 days of inpatient rehabilitation. Tested factors were the expanded disability scale (EDSS) score, laterality of MS, age, sex, hand dominance, time of day, session, trial (first or second), time between sessions, and the reported day form. A second model used these factors to examine the self-reported day form of patients. Linear mixed effects modelling indicated the tapping test to have a good inter-trial (proportional variance < 0.01) and inter-session reliability (non-significant; when controlling for time between sessions), an influence of hand-dominance (proportional variance 0.08), to be strongly associated with the EDSS (eta2 = 0.22, interaction with laterality of MS eta2 = 0.12) and to be not associated with the reported day form. The model explained 87% (p < 0.01) of variance in tapping performance. Lastly, we were able to observe a positive effect of neurologic inpatient rehabilitation on task performance obvious from a significant effect of the time between sessions (eta2 = 0.007; longer time spans between sessions were associated with higher increments in performance). Day form was only impacted by EDSS and the time of the day (p < 0.01, R2 = 0.57, eta2 TIME = 0.017, eta2 EDSS = 01.19). We conclude that the tapping test is a reliable and valid assessment tool for MS.
format	article
author	Philipp Gulde Heike Vojta Joachim Hermsdörfer Peter Rieckmann
author_facet	Philipp Gulde Heike Vojta Joachim Hermsdörfer Peter Rieckmann
author_sort	Philipp Gulde
title	State and trait of finger tapping performance in multiple sclerosis
title_short	State and trait of finger tapping performance in multiple sclerosis
title_full	State and trait of finger tapping performance in multiple sclerosis
title_fullStr	State and trait of finger tapping performance in multiple sclerosis
title_full_unstemmed	State and trait of finger tapping performance in multiple sclerosis
title_sort	state and trait of finger tapping performance in multiple sclerosis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/2d5acb2849b046c1a85371f084e2e3b8
work_keys_str_mv	AT philippgulde stateandtraitoffingertappingperformanceinmultiplesclerosis AT heikevojta stateandtraitoffingertappingperformanceinmultiplesclerosis AT joachimhermsdorfer stateandtraitoffingertappingperformanceinmultiplesclerosis AT peterrieckmann stateandtraitoffingertappingperformanceinmultiplesclerosis
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State and trait of finger tapping performance in multiple sclerosis

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