Negative Association between Acrylamide Exposure and Metabolic Syndrome Markers in Adult Population

Metabolic syndrome encompasses multiple conditions that increase the risk of cardiovascular disease, and exposure to environmental chemicals can cause metabolic syndrome. This cross-sectional study analyzed data from the US National Health and Nutrition Examination Survey (2003–2006) on 4318 adult p...

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Autores principales:	Chun-Chi Hung, Yung-Wen Cheng, Wei-Liang Chen, Wen-Hui Fang
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	acrylamide glycidamide metabolic syndrome NHANES Medicine R
Acceso en línea:	https://doaj.org/article/2d5e4702607f46989317d4e978174b50
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spelling	oai:doaj.org-article:2d5e4702607f46989317d4e978174b502021-11-25T17:49:44ZNegative Association between Acrylamide Exposure and Metabolic Syndrome Markers in Adult Population10.3390/ijerph1822119491660-46011661-7827https://doaj.org/article/2d5e4702607f46989317d4e978174b502021-11-01T00:00:00Zhttps://www.mdpi.com/1660-4601/18/22/11949https://doaj.org/toc/1661-7827https://doaj.org/toc/1660-4601Metabolic syndrome encompasses multiple conditions that increase the risk of cardiovascular disease, and exposure to environmental chemicals can cause metabolic syndrome. This cross-sectional study analyzed data from the US National Health and Nutrition Examination Survey (2003–2006) on 4318 adult participants to assess the association between acrylamide (AA) exposure and metabolic syndrome. Concentrations of hemoglobin-adducted AA (HbAA) and hemoglobin-adducted glycidamide (HbGA) were evaluated. Metabolic syndrome markers related to HbAA and HbGA and the effect of exposure to AA and GA on the prevalence of metabolic syndrome were studied by ANOVA and multivariate logistic regression analyses, respectively. HbAA concentration inversely correlated with the number of metabolic syndrome markers (<i>p</i> < 0.05). An increased HbAA concentration was noted with reduced high triglyceride and low high-density lipoprotein cholesterol levels in the adjusted model (<i>p</i> < 0.05). High fasting plasma glucose level significantly correlated with HbGA concentration in the adjusted model. In conclusion, AA exposure alters metabolic syndrome markers in adults. Additional clinical and animal studies will clarify the role of AA exposure at different stages in the progression of metabolic syndrome-related diseases.Chun-Chi HungYung-Wen ChengWei-Liang ChenWen-Hui FangMDPI AGarticleacrylamideglycidamidemetabolic syndromeNHANESMedicineRENInternational Journal of Environmental Research and Public Health, Vol 18, Iss 11949, p 11949 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	acrylamide glycidamide metabolic syndrome NHANES Medicine R
spellingShingle	acrylamide glycidamide metabolic syndrome NHANES Medicine R Chun-Chi Hung Yung-Wen Cheng Wei-Liang Chen Wen-Hui Fang Negative Association between Acrylamide Exposure and Metabolic Syndrome Markers in Adult Population
description	Metabolic syndrome encompasses multiple conditions that increase the risk of cardiovascular disease, and exposure to environmental chemicals can cause metabolic syndrome. This cross-sectional study analyzed data from the US National Health and Nutrition Examination Survey (2003–2006) on 4318 adult participants to assess the association between acrylamide (AA) exposure and metabolic syndrome. Concentrations of hemoglobin-adducted AA (HbAA) and hemoglobin-adducted glycidamide (HbGA) were evaluated. Metabolic syndrome markers related to HbAA and HbGA and the effect of exposure to AA and GA on the prevalence of metabolic syndrome were studied by ANOVA and multivariate logistic regression analyses, respectively. HbAA concentration inversely correlated with the number of metabolic syndrome markers (<i>p</i> < 0.05). An increased HbAA concentration was noted with reduced high triglyceride and low high-density lipoprotein cholesterol levels in the adjusted model (<i>p</i> < 0.05). High fasting plasma glucose level significantly correlated with HbGA concentration in the adjusted model. In conclusion, AA exposure alters metabolic syndrome markers in adults. Additional clinical and animal studies will clarify the role of AA exposure at different stages in the progression of metabolic syndrome-related diseases.
format	article
author	Chun-Chi Hung Yung-Wen Cheng Wei-Liang Chen Wen-Hui Fang
author_facet	Chun-Chi Hung Yung-Wen Cheng Wei-Liang Chen Wen-Hui Fang
author_sort	Chun-Chi Hung
title	Negative Association between Acrylamide Exposure and Metabolic Syndrome Markers in Adult Population
title_short	Negative Association between Acrylamide Exposure and Metabolic Syndrome Markers in Adult Population
title_full	Negative Association between Acrylamide Exposure and Metabolic Syndrome Markers in Adult Population
title_fullStr	Negative Association between Acrylamide Exposure and Metabolic Syndrome Markers in Adult Population
title_full_unstemmed	Negative Association between Acrylamide Exposure and Metabolic Syndrome Markers in Adult Population
title_sort	negative association between acrylamide exposure and metabolic syndrome markers in adult population
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/2d5e4702607f46989317d4e978174b50
work_keys_str_mv	AT chunchihung negativeassociationbetweenacrylamideexposureandmetabolicsyndromemarkersinadultpopulation AT yungwencheng negativeassociationbetweenacrylamideexposureandmetabolicsyndromemarkersinadultpopulation AT weiliangchen negativeassociationbetweenacrylamideexposureandmetabolicsyndromemarkersinadultpopulation AT wenhuifang negativeassociationbetweenacrylamideexposureandmetabolicsyndromemarkersinadultpopulation
_version_	1718411975536410624

Negative Association between Acrylamide Exposure and Metabolic Syndrome Markers in Adult Population

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