Oral versus topical carbonic anhydrase inhibitors in ocular hypertension after scleral tunnel cataract surgery

Abdulmoghni Al-Barrag1, Motaher Al-Shaer1, Nabil Al-Matary2, Mahfoud Bamashmous11Ophthalmic Department, Faculty of Medicine and Health Sciences, Sana&rsquo;a University, Sana&rsquo;a, Republic of Yemen; 2Ophthalmic Department, Military Hospital, Sana&rsquo;a, Republic of Yeme...

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Autores principales:	Abdulmoghni Al-Barrag, Motaher Al-Shaer, Nabil Al-Matary, Mahfoud Bamashmous
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2009
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/2d600a03976d42df9d58b3950d67a4af
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spelling	oai:doaj.org-article:2d600a03976d42df9d58b3950d67a4af2021-12-02T07:01:56ZOral versus topical carbonic anhydrase inhibitors in ocular hypertension after scleral tunnel cataract surgery1177-54671177-5483https://doaj.org/article/2d600a03976d42df9d58b3950d67a4af2009-06-01T00:00:00Zhttp://www.dovepress.com/oral-versus-topical-carbonic-anhydrase-inhibitors-in-ocular-hypertensi-a3248https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483Abdulmoghni Al-Barrag1, Motaher Al-Shaer1, Nabil Al-Matary2, Mahfoud Bamashmous11Ophthalmic Department, Faculty of Medicine and Health Sciences, Sana&rsquo;a University, Sana&rsquo;a, Republic of Yemen; 2Ophthalmic Department, Military Hospital, Sana&rsquo;a, Republic of YemenPurpose: To compare the effect of oral acetazolamide and topical 2% dorzolamide in prevention of ocular hypertension after scleral tunnel cataract surgery.Setting: Ophthalmic department, Sana&rsquo;a University, Yemen Sana&rsquo;a from March 2007 to October 2007.Methods: This prospective double-blind, randomized study included 150 eyes undergoing scleral tunnel cataract surgery with hard posterior chamber intraocular implantation. Methylcellulose was used as the viscoelastic in all surgery cases. Patients were assigned to one of three groups: group 1: topical gentamicin eye drops (control; n = 52); group 2: systemic acetazolamide 250 mg (n = 45); and group 3: topical 2% dorzolamide (n = 53). Acetazolamide patients received one 250 mg tablet, one hour before surgery, then half a tablet every eight hours. A topical dorzolamide 2% or gentamicin was applied in one drop one hour before surgery then every eight hours, for three days postoperatively. Intraocular pressures (IOP) were measured by Goldman applanation tonometry one hour preoperatively and 16, 24, and 48 hours postoperatively. Results: At 16 hours, IOP between the three groups increased significantly with a statistically significant p-value of 0.008, but the mean IOP of acetazolamide patients was less than other groups. IOP nearly returned to the normal level 24 and 48 hours postoperatively, but this was not statistically significant (p = 0.452 and 0.138, respectively).Conclusion: Acetazolamide offers better IOP control than topical dorzolamide 2% in preventing ocular hypertension after scleral tunnel cataract surgery. Keywords: cataract surgery, ocular hypertension, viscoelastic, dorzolamide, intraocular pressure Abdulmoghni Al-BarragMotaher Al-ShaerNabil Al-MataryMahfoud BamashmousDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2009, Iss default, Pp 357-362 (2009)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Abdulmoghni Al-Barrag Motaher Al-Shaer Nabil Al-Matary Mahfoud Bamashmous Oral versus topical carbonic anhydrase inhibitors in ocular hypertension after scleral tunnel cataract surgery
description	Abdulmoghni Al-Barrag1, Motaher Al-Shaer1, Nabil Al-Matary2, Mahfoud Bamashmous11Ophthalmic Department, Faculty of Medicine and Health Sciences, Sana&rsquo;a University, Sana&rsquo;a, Republic of Yemen; 2Ophthalmic Department, Military Hospital, Sana&rsquo;a, Republic of YemenPurpose: To compare the effect of oral acetazolamide and topical 2% dorzolamide in prevention of ocular hypertension after scleral tunnel cataract surgery.Setting: Ophthalmic department, Sana&rsquo;a University, Yemen Sana&rsquo;a from March 2007 to October 2007.Methods: This prospective double-blind, randomized study included 150 eyes undergoing scleral tunnel cataract surgery with hard posterior chamber intraocular implantation. Methylcellulose was used as the viscoelastic in all surgery cases. Patients were assigned to one of three groups: group 1: topical gentamicin eye drops (control; n = 52); group 2: systemic acetazolamide 250 mg (n = 45); and group 3: topical 2% dorzolamide (n = 53). Acetazolamide patients received one 250 mg tablet, one hour before surgery, then half a tablet every eight hours. A topical dorzolamide 2% or gentamicin was applied in one drop one hour before surgery then every eight hours, for three days postoperatively. Intraocular pressures (IOP) were measured by Goldman applanation tonometry one hour preoperatively and 16, 24, and 48 hours postoperatively. Results: At 16 hours, IOP between the three groups increased significantly with a statistically significant p-value of 0.008, but the mean IOP of acetazolamide patients was less than other groups. IOP nearly returned to the normal level 24 and 48 hours postoperatively, but this was not statistically significant (p = 0.452 and 0.138, respectively).Conclusion: Acetazolamide offers better IOP control than topical dorzolamide 2% in preventing ocular hypertension after scleral tunnel cataract surgery. Keywords: cataract surgery, ocular hypertension, viscoelastic, dorzolamide, intraocular pressure
format	article
author	Abdulmoghni Al-Barrag Motaher Al-Shaer Nabil Al-Matary Mahfoud Bamashmous
author_facet	Abdulmoghni Al-Barrag Motaher Al-Shaer Nabil Al-Matary Mahfoud Bamashmous
author_sort	Abdulmoghni Al-Barrag
title	Oral versus topical carbonic anhydrase inhibitors in ocular hypertension after scleral tunnel cataract surgery
title_short	Oral versus topical carbonic anhydrase inhibitors in ocular hypertension after scleral tunnel cataract surgery
title_full	Oral versus topical carbonic anhydrase inhibitors in ocular hypertension after scleral tunnel cataract surgery
title_fullStr	Oral versus topical carbonic anhydrase inhibitors in ocular hypertension after scleral tunnel cataract surgery
title_full_unstemmed	Oral versus topical carbonic anhydrase inhibitors in ocular hypertension after scleral tunnel cataract surgery
title_sort	oral versus topical carbonic anhydrase inhibitors in ocular hypertension after scleral tunnel cataract surgery
publisher	Dove Medical Press
publishDate	2009
url	https://doaj.org/article/2d600a03976d42df9d58b3950d67a4af
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Oral versus topical carbonic anhydrase inhibitors in ocular hypertension after scleral tunnel cataract surgery

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