Modulation of telomere protection by the PI3K/AKT pathway

Regulation of telomeres and the insulin/PI3K pathway both have roles in aging and cancer development but have not been functionally linked. Here the authors demonstrate that PI3K, via downstream targets, regulates TRF1 via phosphorylation.

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Autores principales:	Marinela Méndez-Pertuz, Paula Martínez, Carmen Blanco-Aparicio, Elena Gómez-Casero, Ana Belen García, Jorge Martínez-Torrecuadrada, Marta Palafox, Javier Cortés, Violeta Serra, Joaquin Pastor, Maria A. Blasco
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2d614c1112c2497aaf67ea663b43f2d5
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spelling	oai:doaj.org-article:2d614c1112c2497aaf67ea663b43f2d52021-12-02T17:01:24ZModulation of telomere protection by the PI3K/AKT pathway10.1038/s41467-017-01329-22041-1723https://doaj.org/article/2d614c1112c2497aaf67ea663b43f2d52017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01329-2https://doaj.org/toc/2041-1723Regulation of telomeres and the insulin/PI3K pathway both have roles in aging and cancer development but have not been functionally linked. Here the authors demonstrate that PI3K, via downstream targets, regulates TRF1 via phosphorylation.Marinela Méndez-PertuzPaula MartínezCarmen Blanco-AparicioElena Gómez-CaseroAna Belen GarcíaJorge Martínez-TorrecuadradaMarta PalafoxJavier CortésVioleta SerraJoaquin PastorMaria A. BlascoNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-17 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Marinela Méndez-Pertuz Paula Martínez Carmen Blanco-Aparicio Elena Gómez-Casero Ana Belen García Jorge Martínez-Torrecuadrada Marta Palafox Javier Cortés Violeta Serra Joaquin Pastor Maria A. Blasco Modulation of telomere protection by the PI3K/AKT pathway
description	Regulation of telomeres and the insulin/PI3K pathway both have roles in aging and cancer development but have not been functionally linked. Here the authors demonstrate that PI3K, via downstream targets, regulates TRF1 via phosphorylation.
format	article
author	Marinela Méndez-Pertuz Paula Martínez Carmen Blanco-Aparicio Elena Gómez-Casero Ana Belen García Jorge Martínez-Torrecuadrada Marta Palafox Javier Cortés Violeta Serra Joaquin Pastor Maria A. Blasco
author_facet	Marinela Méndez-Pertuz Paula Martínez Carmen Blanco-Aparicio Elena Gómez-Casero Ana Belen García Jorge Martínez-Torrecuadrada Marta Palafox Javier Cortés Violeta Serra Joaquin Pastor Maria A. Blasco
author_sort	Marinela Méndez-Pertuz
title	Modulation of telomere protection by the PI3K/AKT pathway
title_short	Modulation of telomere protection by the PI3K/AKT pathway
title_full	Modulation of telomere protection by the PI3K/AKT pathway
title_fullStr	Modulation of telomere protection by the PI3K/AKT pathway
title_full_unstemmed	Modulation of telomere protection by the PI3K/AKT pathway
title_sort	modulation of telomere protection by the pi3k/akt pathway
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/2d614c1112c2497aaf67ea663b43f2d5
work_keys_str_mv	AT marinelamendezpertuz modulationoftelomereprotectionbythepi3kaktpathway AT paulamartinez modulationoftelomereprotectionbythepi3kaktpathway AT carmenblancoaparicio modulationoftelomereprotectionbythepi3kaktpathway AT elenagomezcasero modulationoftelomereprotectionbythepi3kaktpathway AT anabelengarcia modulationoftelomereprotectionbythepi3kaktpathway AT jorgemartineztorrecuadrada modulationoftelomereprotectionbythepi3kaktpathway AT martapalafox modulationoftelomereprotectionbythepi3kaktpathway AT javiercortes modulationoftelomereprotectionbythepi3kaktpathway AT violetaserra modulationoftelomereprotectionbythepi3kaktpathway AT joaquinpastor modulationoftelomereprotectionbythepi3kaktpathway AT mariaablasco modulationoftelomereprotectionbythepi3kaktpathway
_version_	1718382136818401280

Modulation of telomere protection by the PI3K/AKT pathway

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