Molecular and phenotypic analysis of rodent models reveals conserved and species-specific modulators of human sarcopenia

Anastasiya Börsch, Daniel Ham, and colleagues generated a time series of phenotypic measurements and RNA-Seq data from mouse skeletal muscle and comparatively analyzed these along comparable rat and human data, to assess the relevance of rodent models for human muscle aging. This study draws attenti...

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Autores principales:	Anastasiya Börsch, Daniel J. Ham, Nitish Mittal, Lionel A. Tintignac, Eugenia Migliavacca, Jérôme N. Feige, Markus A. Rüegg, Mihaela Zavolan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/2d627932b677454c8644b2aba9b64e4a
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spelling	oai:doaj.org-article:2d627932b677454c8644b2aba9b64e4a2021-12-02T12:09:17ZMolecular and phenotypic analysis of rodent models reveals conserved and species-specific modulators of human sarcopenia10.1038/s42003-021-01723-z2399-3642https://doaj.org/article/2d627932b677454c8644b2aba9b64e4a2021-02-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-01723-zhttps://doaj.org/toc/2399-3642Anastasiya Börsch, Daniel Ham, and colleagues generated a time series of phenotypic measurements and RNA-Seq data from mouse skeletal muscle and comparatively analyzed these along comparable rat and human data, to assess the relevance of rodent models for human muscle aging. This study draws attention to the utility of phenotypic measurements in analyzing aging-related molecular data, as several measurements such as muscle mass, were better indicators of muscle health than chronological age.Anastasiya BörschDaniel J. HamNitish MittalLionel A. TintignacEugenia MigliavaccaJérôme N. FeigeMarkus A. RüeggMihaela ZavolanNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Anastasiya Börsch Daniel J. Ham Nitish Mittal Lionel A. Tintignac Eugenia Migliavacca Jérôme N. Feige Markus A. Rüegg Mihaela Zavolan Molecular and phenotypic analysis of rodent models reveals conserved and species-specific modulators of human sarcopenia
description	Anastasiya Börsch, Daniel Ham, and colleagues generated a time series of phenotypic measurements and RNA-Seq data from mouse skeletal muscle and comparatively analyzed these along comparable rat and human data, to assess the relevance of rodent models for human muscle aging. This study draws attention to the utility of phenotypic measurements in analyzing aging-related molecular data, as several measurements such as muscle mass, were better indicators of muscle health than chronological age.
format	article
author	Anastasiya Börsch Daniel J. Ham Nitish Mittal Lionel A. Tintignac Eugenia Migliavacca Jérôme N. Feige Markus A. Rüegg Mihaela Zavolan
author_facet	Anastasiya Börsch Daniel J. Ham Nitish Mittal Lionel A. Tintignac Eugenia Migliavacca Jérôme N. Feige Markus A. Rüegg Mihaela Zavolan
author_sort	Anastasiya Börsch
title	Molecular and phenotypic analysis of rodent models reveals conserved and species-specific modulators of human sarcopenia
title_short	Molecular and phenotypic analysis of rodent models reveals conserved and species-specific modulators of human sarcopenia
title_full	Molecular and phenotypic analysis of rodent models reveals conserved and species-specific modulators of human sarcopenia
title_fullStr	Molecular and phenotypic analysis of rodent models reveals conserved and species-specific modulators of human sarcopenia
title_full_unstemmed	Molecular and phenotypic analysis of rodent models reveals conserved and species-specific modulators of human sarcopenia
title_sort	molecular and phenotypic analysis of rodent models reveals conserved and species-specific modulators of human sarcopenia
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/2d627932b677454c8644b2aba9b64e4a
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Molecular and phenotypic analysis of rodent models reveals conserved and species-specific modulators of human sarcopenia

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