Protective mucosal immunity against SARS-CoV-2 after heterologous systemic prime-mucosal boost immunization

Protective mucosal immunity against SARS-CoV-2 after heterologous systemic prime-mucosal boost immunization

While current COVID-19 vaccines provide certain protection, more effective vaccination strategies are still desirable. Here the authors show, using mouse vaccination models, that priming with a systemic mRNA and boosting with an intranasal adenoviral vector vaccine induces comprehensive T cell and m...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Dennis Lapuente, Jana Fuchs, Jonas Willar, Ana Vieira Antão, Valentina Eberlein, Nadja Uhlig, Leila Issmail, Anna Schmidt, Friederike Oltmanns, Antonia Sophia Peter, Sandra Mueller-Schmucker, Pascal Irrgang, Kirsten Fraedrich, Andrea Cara, Markus Hoffmann, Stefan Pöhlmann, Armin Ensser, Cordula Pertl, Torsten Willert, Christian Thirion, Thomas Grunwald, Klaus Überla, Matthias Tenbusch
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/2d658f5bfe1141c4acf2fa4bf72300b6
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:2d658f5bfe1141c4acf2fa4bf72300b6
record_format dspace
spelling oai:doaj.org-article:2d658f5bfe1141c4acf2fa4bf72300b62021-11-28T12:34:49ZProtective mucosal immunity against SARS-CoV-2 after heterologous systemic prime-mucosal boost immunization10.1038/s41467-021-27063-42041-1723https://doaj.org/article/2d658f5bfe1141c4acf2fa4bf72300b62021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-27063-4https://doaj.org/toc/2041-1723While current COVID-19 vaccines provide certain protection, more effective vaccination strategies are still desirable. Here the authors show, using mouse vaccination models, that priming with a systemic mRNA and boosting with an intranasal adenoviral vector vaccine induces comprehensive T cell and mucosal immunity.Dennis LapuenteJana FuchsJonas WillarAna Vieira AntãoValentina EberleinNadja UhligLeila IssmailAnna SchmidtFriederike OltmannsAntonia Sophia PeterSandra Mueller-SchmuckerPascal IrrgangKirsten FraedrichAndrea CaraMarkus HoffmannStefan PöhlmannArmin EnsserCordula PertlTorsten WillertChristian ThirionThomas GrunwaldKlaus ÜberlaMatthias TenbuschNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Dennis Lapuente
Jana Fuchs
Jonas Willar
Ana Vieira Antão
Valentina Eberlein
Nadja Uhlig
Leila Issmail
Anna Schmidt
Friederike Oltmanns
Antonia Sophia Peter
Sandra Mueller-Schmucker
Pascal Irrgang
Kirsten Fraedrich
Andrea Cara
Markus Hoffmann
Stefan Pöhlmann
Armin Ensser
Cordula Pertl
Torsten Willert
Christian Thirion
Thomas Grunwald
Klaus Überla
Matthias Tenbusch
Protective mucosal immunity against SARS-CoV-2 after heterologous systemic prime-mucosal boost immunization
description While current COVID-19 vaccines provide certain protection, more effective vaccination strategies are still desirable. Here the authors show, using mouse vaccination models, that priming with a systemic mRNA and boosting with an intranasal adenoviral vector vaccine induces comprehensive T cell and mucosal immunity.
format article
author Dennis Lapuente
Jana Fuchs
Jonas Willar
Ana Vieira Antão
Valentina Eberlein
Nadja Uhlig
Leila Issmail
Anna Schmidt
Friederike Oltmanns
Antonia Sophia Peter
Sandra Mueller-Schmucker
Pascal Irrgang
Kirsten Fraedrich
Andrea Cara
Markus Hoffmann
Stefan Pöhlmann
Armin Ensser
Cordula Pertl
Torsten Willert
Christian Thirion
Thomas Grunwald
Klaus Überla
Matthias Tenbusch
author_facet Dennis Lapuente
Jana Fuchs
Jonas Willar
Ana Vieira Antão
Valentina Eberlein
Nadja Uhlig
Leila Issmail
Anna Schmidt
Friederike Oltmanns
Antonia Sophia Peter
Sandra Mueller-Schmucker
Pascal Irrgang
Kirsten Fraedrich
Andrea Cara
Markus Hoffmann
Stefan Pöhlmann
Armin Ensser
Cordula Pertl
Torsten Willert
Christian Thirion
Thomas Grunwald
Klaus Überla
Matthias Tenbusch
author_sort Dennis Lapuente
title Protective mucosal immunity against SARS-CoV-2 after heterologous systemic prime-mucosal boost immunization
title_short Protective mucosal immunity against SARS-CoV-2 after heterologous systemic prime-mucosal boost immunization
title_full Protective mucosal immunity against SARS-CoV-2 after heterologous systemic prime-mucosal boost immunization
title_fullStr Protective mucosal immunity against SARS-CoV-2 after heterologous systemic prime-mucosal boost immunization
title_full_unstemmed Protective mucosal immunity against SARS-CoV-2 after heterologous systemic prime-mucosal boost immunization
title_sort protective mucosal immunity against sars-cov-2 after heterologous systemic prime-mucosal boost immunization
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/2d658f5bfe1141c4acf2fa4bf72300b6
work_keys_str_mv AT dennislapuente protectivemucosalimmunityagainstsarscov2afterheterologoussystemicprimemucosalboostimmunization
AT janafuchs protectivemucosalimmunityagainstsarscov2afterheterologoussystemicprimemucosalboostimmunization
AT jonaswillar protectivemucosalimmunityagainstsarscov2afterheterologoussystemicprimemucosalboostimmunization
AT anavieiraantao protectivemucosalimmunityagainstsarscov2afterheterologoussystemicprimemucosalboostimmunization
AT valentinaeberlein protectivemucosalimmunityagainstsarscov2afterheterologoussystemicprimemucosalboostimmunization
AT nadjauhlig protectivemucosalimmunityagainstsarscov2afterheterologoussystemicprimemucosalboostimmunization
AT leilaissmail protectivemucosalimmunityagainstsarscov2afterheterologoussystemicprimemucosalboostimmunization
AT annaschmidt protectivemucosalimmunityagainstsarscov2afterheterologoussystemicprimemucosalboostimmunization
AT friederikeoltmanns protectivemucosalimmunityagainstsarscov2afterheterologoussystemicprimemucosalboostimmunization
AT antoniasophiapeter protectivemucosalimmunityagainstsarscov2afterheterologoussystemicprimemucosalboostimmunization
AT sandramuellerschmucker protectivemucosalimmunityagainstsarscov2afterheterologoussystemicprimemucosalboostimmunization
AT pascalirrgang protectivemucosalimmunityagainstsarscov2afterheterologoussystemicprimemucosalboostimmunization
AT kirstenfraedrich protectivemucosalimmunityagainstsarscov2afterheterologoussystemicprimemucosalboostimmunization
AT andreacara protectivemucosalimmunityagainstsarscov2afterheterologoussystemicprimemucosalboostimmunization
AT markushoffmann protectivemucosalimmunityagainstsarscov2afterheterologoussystemicprimemucosalboostimmunization
AT stefanpohlmann protectivemucosalimmunityagainstsarscov2afterheterologoussystemicprimemucosalboostimmunization
AT arminensser protectivemucosalimmunityagainstsarscov2afterheterologoussystemicprimemucosalboostimmunization
AT cordulapertl protectivemucosalimmunityagainstsarscov2afterheterologoussystemicprimemucosalboostimmunization
AT torstenwillert protectivemucosalimmunityagainstsarscov2afterheterologoussystemicprimemucosalboostimmunization
AT christianthirion protectivemucosalimmunityagainstsarscov2afterheterologoussystemicprimemucosalboostimmunization
AT thomasgrunwald protectivemucosalimmunityagainstsarscov2afterheterologoussystemicprimemucosalboostimmunization
AT klausuberla protectivemucosalimmunityagainstsarscov2afterheterologoussystemicprimemucosalboostimmunization
AT matthiastenbusch protectivemucosalimmunityagainstsarscov2afterheterologoussystemicprimemucosalboostimmunization
_version_ 1718407880992882688

Ejemplares similares