Dorsal horn neurons release extracellular ATP in a VNUT-dependent manner that underlies neuropathic pain

Purinergic receptor activation by extracellular ATP in the dorsal horn contributes to neuropathic pain, but which cell types release ATP in this context is not known. The authors show in a mouse model of neuropathic pain that ATP is released by dorsal horn neurons, a process requiring the vesicular...

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Autores principales:	Takahiro Masuda, Yui Ozono, Satsuki Mikuriya, Yuta Kohro, Hidetoshi Tozaki-Saitoh, Ken Iwatsuki, Hisayuki Uneyama, Reiko Ichikawa, Michael W. Salter, Makoto Tsuda, Kazuhide Inoue
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2d65dc25191b4bbb8171bee36fe5b451
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spelling	oai:doaj.org-article:2d65dc25191b4bbb8171bee36fe5b4512021-12-02T17:31:47ZDorsal horn neurons release extracellular ATP in a VNUT-dependent manner that underlies neuropathic pain10.1038/ncomms125292041-1723https://doaj.org/article/2d65dc25191b4bbb8171bee36fe5b4512016-08-01T00:00:00Zhttps://doi.org/10.1038/ncomms12529https://doaj.org/toc/2041-1723Purinergic receptor activation by extracellular ATP in the dorsal horn contributes to neuropathic pain, but which cell types release ATP in this context is not known. The authors show in a mouse model of neuropathic pain that ATP is released by dorsal horn neurons, a process requiring the vesicular nucleotide transporter, VNUT.Takahiro MasudaYui OzonoSatsuki MikuriyaYuta KohroHidetoshi Tozaki-SaitohKen IwatsukiHisayuki UneyamaReiko IchikawaMichael W. SalterMakoto TsudaKazuhide InoueNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Takahiro Masuda Yui Ozono Satsuki Mikuriya Yuta Kohro Hidetoshi Tozaki-Saitoh Ken Iwatsuki Hisayuki Uneyama Reiko Ichikawa Michael W. Salter Makoto Tsuda Kazuhide Inoue Dorsal horn neurons release extracellular ATP in a VNUT-dependent manner that underlies neuropathic pain
description	Purinergic receptor activation by extracellular ATP in the dorsal horn contributes to neuropathic pain, but which cell types release ATP in this context is not known. The authors show in a mouse model of neuropathic pain that ATP is released by dorsal horn neurons, a process requiring the vesicular nucleotide transporter, VNUT.
format	article
author	Takahiro Masuda Yui Ozono Satsuki Mikuriya Yuta Kohro Hidetoshi Tozaki-Saitoh Ken Iwatsuki Hisayuki Uneyama Reiko Ichikawa Michael W. Salter Makoto Tsuda Kazuhide Inoue
author_facet	Takahiro Masuda Yui Ozono Satsuki Mikuriya Yuta Kohro Hidetoshi Tozaki-Saitoh Ken Iwatsuki Hisayuki Uneyama Reiko Ichikawa Michael W. Salter Makoto Tsuda Kazuhide Inoue
author_sort	Takahiro Masuda
title	Dorsal horn neurons release extracellular ATP in a VNUT-dependent manner that underlies neuropathic pain
title_short	Dorsal horn neurons release extracellular ATP in a VNUT-dependent manner that underlies neuropathic pain
title_full	Dorsal horn neurons release extracellular ATP in a VNUT-dependent manner that underlies neuropathic pain
title_fullStr	Dorsal horn neurons release extracellular ATP in a VNUT-dependent manner that underlies neuropathic pain
title_full_unstemmed	Dorsal horn neurons release extracellular ATP in a VNUT-dependent manner that underlies neuropathic pain
title_sort	dorsal horn neurons release extracellular atp in a vnut-dependent manner that underlies neuropathic pain
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/2d65dc25191b4bbb8171bee36fe5b451
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Dorsal horn neurons release extracellular ATP in a VNUT-dependent manner that underlies neuropathic pain

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