HEMATOLOGICAL DISORDERS OF PROPYLTHIOURACIL IN THYROID PATIENTS AT TERTIARY CARE HOSPITAL OF HYDERABAD

Objective: To find out the frequency of anemia, agranulocytosis and thrombocytopenia in hyperthyroid patients after the use of propylthiouracil. Study Design: Cross sectional study. Place and Duration of Study: Out Door Patients Department and Pathology Laboratory in Liaquat University Medical...

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Autores principales:	Uzma Naz Shaikh, Muhammad Ali Ghoto, Abdullah Dayo, Mudassar Iqbal Arain, Jibran Khan
Formato:	article
Lenguaje:	EN
Publicado:	Army Medical College Rawalpindi 2021
Materias:	agranulocytosis anemia hyperthyroid propylthiouracil Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/2d6e7d23b4ee476b9de3a41791f3e3cc
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spelling	oai:doaj.org-article:2d6e7d23b4ee476b9de3a41791f3e3cc2021-11-23T03:52:49ZHEMATOLOGICAL DISORDERS OF PROPYLTHIOURACIL IN THYROID PATIENTS AT TERTIARY CARE HOSPITAL OF HYDERABAD0030-96482411-8842https://doaj.org/article/2d6e7d23b4ee476b9de3a41791f3e3cc2021-10-01T00:00:00Zhttps://www.pafmj.org/index.php/PAFMJ/article/view/3682/3622https://doaj.org/toc/0030-9648https://doaj.org/toc/2411-8842Objective: To find out the frequency of anemia, agranulocytosis and thrombocytopenia in hyperthyroid patients after the use of propylthiouracil. Study Design: Cross sectional study. Place and Duration of Study: Out Door Patients Department and Pathology Laboratory in Liaquat University Medical & Health Sciences, Hospital Hyderabad/Jamshoro, from May 2016 to Apr 2017. Methodology: Two hundred cases, comprising of adult patients were categorized into five groups, age group 15-30 years 79 (39.5%) patients presenting the highest out of total, age group 31-45 years 68 (34%) patients, age group 46-60 years 36 (18%), age group 61-75 years 14 (7%) patients, age group >75 years 3 (1.5) patients. Complete blood count was analyzed on Sysmex Kx21 and thyroid profiles were analyzed on Elecysis 2010 from the Pathology Department. SPSS version 22 was used for data analysis. Result: Out of total patients, 32 (16%) were males and 168 (84%) were females with mean age of 37.44 ± 14.82 years. Majority of patients 68 (34%) were anemic, while 4 (2%) had agranulocytosis and 11 (5.5%) had thrombocytopenia. Headache was reported in 111 (55.5%), exophthalmos in 106 (53%), sore throat in 172 (86%), fever in 136 (68%) and weight loss in 95 (47.5%) patients. Conclusion: Propylthiouracil causes defective hematopoiesis in hyperthyroid patients because propylthiouracil has adverse suppressive effects on bone marrow.Uzma Naz ShaikhMuhammad Ali GhotoAbdullah DayoMudassar Iqbal ArainJibran KhanArmy Medical College RawalpindiarticleagranulocytosisanemiahyperthyroidpropylthiouracilMedicineRMedicine (General)R5-920ENPakistan Armed Forces Medical Journal, Vol 71, Iss 5, Pp 1787-1790 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	agranulocytosis anemia hyperthyroid propylthiouracil Medicine R Medicine (General) R5-920
spellingShingle	agranulocytosis anemia hyperthyroid propylthiouracil Medicine R Medicine (General) R5-920 Uzma Naz Shaikh Muhammad Ali Ghoto Abdullah Dayo Mudassar Iqbal Arain Jibran Khan HEMATOLOGICAL DISORDERS OF PROPYLTHIOURACIL IN THYROID PATIENTS AT TERTIARY CARE HOSPITAL OF HYDERABAD
description	Objective: To find out the frequency of anemia, agranulocytosis and thrombocytopenia in hyperthyroid patients after the use of propylthiouracil. Study Design: Cross sectional study. Place and Duration of Study: Out Door Patients Department and Pathology Laboratory in Liaquat University Medical & Health Sciences, Hospital Hyderabad/Jamshoro, from May 2016 to Apr 2017. Methodology: Two hundred cases, comprising of adult patients were categorized into five groups, age group 15-30 years 79 (39.5%) patients presenting the highest out of total, age group 31-45 years 68 (34%) patients, age group 46-60 years 36 (18%), age group 61-75 years 14 (7%) patients, age group >75 years 3 (1.5) patients. Complete blood count was analyzed on Sysmex Kx21 and thyroid profiles were analyzed on Elecysis 2010 from the Pathology Department. SPSS version 22 was used for data analysis. Result: Out of total patients, 32 (16%) were males and 168 (84%) were females with mean age of 37.44 ± 14.82 years. Majority of patients 68 (34%) were anemic, while 4 (2%) had agranulocytosis and 11 (5.5%) had thrombocytopenia. Headache was reported in 111 (55.5%), exophthalmos in 106 (53%), sore throat in 172 (86%), fever in 136 (68%) and weight loss in 95 (47.5%) patients. Conclusion: Propylthiouracil causes defective hematopoiesis in hyperthyroid patients because propylthiouracil has adverse suppressive effects on bone marrow.
format	article
author	Uzma Naz Shaikh Muhammad Ali Ghoto Abdullah Dayo Mudassar Iqbal Arain Jibran Khan
author_facet	Uzma Naz Shaikh Muhammad Ali Ghoto Abdullah Dayo Mudassar Iqbal Arain Jibran Khan
author_sort	Uzma Naz Shaikh
title	HEMATOLOGICAL DISORDERS OF PROPYLTHIOURACIL IN THYROID PATIENTS AT TERTIARY CARE HOSPITAL OF HYDERABAD
title_short	HEMATOLOGICAL DISORDERS OF PROPYLTHIOURACIL IN THYROID PATIENTS AT TERTIARY CARE HOSPITAL OF HYDERABAD
title_full	HEMATOLOGICAL DISORDERS OF PROPYLTHIOURACIL IN THYROID PATIENTS AT TERTIARY CARE HOSPITAL OF HYDERABAD
title_fullStr	HEMATOLOGICAL DISORDERS OF PROPYLTHIOURACIL IN THYROID PATIENTS AT TERTIARY CARE HOSPITAL OF HYDERABAD
title_full_unstemmed	HEMATOLOGICAL DISORDERS OF PROPYLTHIOURACIL IN THYROID PATIENTS AT TERTIARY CARE HOSPITAL OF HYDERABAD
title_sort	hematological disorders of propylthiouracil in thyroid patients at tertiary care hospital of hyderabad
publisher	Army Medical College Rawalpindi
publishDate	2021
url	https://doaj.org/article/2d6e7d23b4ee476b9de3a41791f3e3cc
work_keys_str_mv	AT uzmanazshaikh hematologicaldisordersofpropylthiouracilinthyroidpatientsattertiarycarehospitalofhyderabad AT muhammadalighoto hematologicaldisordersofpropylthiouracilinthyroidpatientsattertiarycarehospitalofhyderabad AT abdullahdayo hematologicaldisordersofpropylthiouracilinthyroidpatientsattertiarycarehospitalofhyderabad AT mudassariqbalarain hematologicaldisordersofpropylthiouracilinthyroidpatientsattertiarycarehospitalofhyderabad AT jibrankhan hematologicaldisordersofpropylthiouracilinthyroidpatientsattertiarycarehospitalofhyderabad
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HEMATOLOGICAL DISORDERS OF PROPYLTHIOURACIL IN THYROID PATIENTS AT TERTIARY CARE HOSPITAL OF HYDERABAD

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