p38-MAPK-mediated translation regulation during early blastocyst development is required for primitive endoderm differentiation in mice

Bora et al. show that an early blastocyst window of p38-MAPK activity regulates ribosome-related gene expression, rRNA precursor processing, polysome formation, and protein translation. This study suggests a distinct role of p38-MAPKs for providing a permissive translational environment during mouse...

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Autores principales:	Pablo Bora, Lenka Gahurova, Tomáš Mašek, Andrea Hauserova, David Potěšil, Denisa Jansova, Andrej Susor, Zbyněk Zdráhal, Anna Ajduk, Martin Pospíšek, Alexander W. Bruce
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/2d718886001a4b338d26b0dc2ade0e25
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spelling	oai:doaj.org-article:2d718886001a4b338d26b0dc2ade0e252021-12-02T17:45:11Zp38-MAPK-mediated translation regulation during early blastocyst development is required for primitive endoderm differentiation in mice10.1038/s42003-021-02290-z2399-3642https://doaj.org/article/2d718886001a4b338d26b0dc2ade0e252021-06-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02290-zhttps://doaj.org/toc/2399-3642Bora et al. show that an early blastocyst window of p38-MAPK activity regulates ribosome-related gene expression, rRNA precursor processing, polysome formation, and protein translation. This study suggests a distinct role of p38-MAPKs for providing a permissive translational environment during mouse blastocyst primitive endoderm differentiation.Pablo BoraLenka GahurovaTomáš MašekAndrea HauserovaDavid PotěšilDenisa JansovaAndrej SusorZbyněk ZdráhalAnna AjdukMartin PospíšekAlexander W. BruceNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-19 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Pablo Bora Lenka Gahurova Tomáš Mašek Andrea Hauserova David Potěšil Denisa Jansova Andrej Susor Zbyněk Zdráhal Anna Ajduk Martin Pospíšek Alexander W. Bruce p38-MAPK-mediated translation regulation during early blastocyst development is required for primitive endoderm differentiation in mice
description	Bora et al. show that an early blastocyst window of p38-MAPK activity regulates ribosome-related gene expression, rRNA precursor processing, polysome formation, and protein translation. This study suggests a distinct role of p38-MAPKs for providing a permissive translational environment during mouse blastocyst primitive endoderm differentiation.
format	article
author	Pablo Bora Lenka Gahurova Tomáš Mašek Andrea Hauserova David Potěšil Denisa Jansova Andrej Susor Zbyněk Zdráhal Anna Ajduk Martin Pospíšek Alexander W. Bruce
author_facet	Pablo Bora Lenka Gahurova Tomáš Mašek Andrea Hauserova David Potěšil Denisa Jansova Andrej Susor Zbyněk Zdráhal Anna Ajduk Martin Pospíšek Alexander W. Bruce
author_sort	Pablo Bora
title	p38-MAPK-mediated translation regulation during early blastocyst development is required for primitive endoderm differentiation in mice
title_short	p38-MAPK-mediated translation regulation during early blastocyst development is required for primitive endoderm differentiation in mice
title_full	p38-MAPK-mediated translation regulation during early blastocyst development is required for primitive endoderm differentiation in mice
title_fullStr	p38-MAPK-mediated translation regulation during early blastocyst development is required for primitive endoderm differentiation in mice
title_full_unstemmed	p38-MAPK-mediated translation regulation during early blastocyst development is required for primitive endoderm differentiation in mice
title_sort	p38-mapk-mediated translation regulation during early blastocyst development is required for primitive endoderm differentiation in mice
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/2d718886001a4b338d26b0dc2ade0e25
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p38-MAPK-mediated translation regulation during early blastocyst development is required for primitive endoderm differentiation in mice

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