p38-MAPK-mediated translation regulation during early blastocyst development is required for primitive endoderm differentiation in mice

p38-MAPK-mediated translation regulation during early blastocyst development is required for primitive endoderm differentiation in mice

Bora et al. show that an early blastocyst window of p38-MAPK activity regulates ribosome-related gene expression, rRNA precursor processing, polysome formation, and protein translation. This study suggests a distinct role of p38-MAPKs for providing a permissive translational environment during mouse...

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Autores principales: Pablo Bora, Lenka Gahurova, Tomáš Mašek, Andrea Hauserova, David Potěšil, Denisa Jansova, Andrej Susor, Zbyněk Zdráhal, Anna Ajduk, Martin Pospíšek, Alexander W. Bruce
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Biology (General)
QH301-705.5
Acceso en línea:https://doaj.org/article/2d718886001a4b338d26b0dc2ade0e25
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