Indispensable role of Galectin-3 in promoting quiescence of hematopoietic stem cells

Long term haematopoitic stem cells (LT-HSCs) are in a quiescent state during homeostasis, which is critical for their maintenance. Here, the authors show that Gal-3 expression in LT-HSCs is induced in response to Tie2 and Mpl and is both necessary and sufficient for LT-HSC quiescence through regulat...

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Autores principales:	Weizhen Jia, Lingyu Kong, Hiroyasu Kidoya, Hisamichi Naito, Fumitaka Muramatsu, Yumiko Hayashi, Han-Yun Hsieh, Daishi Yamakawa, Daniel K. Hsu, Fu-Tong Liu, Nobuyuki Takakura
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2d73afe6425b4fe38178265b2b6f30da
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spelling	oai:doaj.org-article:2d73afe6425b4fe38178265b2b6f30da2021-12-02T14:37:37ZIndispensable role of Galectin-3 in promoting quiescence of hematopoietic stem cells10.1038/s41467-021-22346-22041-1723https://doaj.org/article/2d73afe6425b4fe38178265b2b6f30da2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22346-2https://doaj.org/toc/2041-1723Long term haematopoitic stem cells (LT-HSCs) are in a quiescent state during homeostasis, which is critical for their maintenance. Here, the authors show that Gal-3 expression in LT-HSCs is induced in response to Tie2 and Mpl and is both necessary and sufficient for LT-HSC quiescence through regulation of p21.Weizhen JiaLingyu KongHiroyasu KidoyaHisamichi NaitoFumitaka MuramatsuYumiko HayashiHan-Yun HsiehDaishi YamakawaDaniel K. HsuFu-Tong LiuNobuyuki TakakuraNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Weizhen Jia Lingyu Kong Hiroyasu Kidoya Hisamichi Naito Fumitaka Muramatsu Yumiko Hayashi Han-Yun Hsieh Daishi Yamakawa Daniel K. Hsu Fu-Tong Liu Nobuyuki Takakura Indispensable role of Galectin-3 in promoting quiescence of hematopoietic stem cells
description	Long term haematopoitic stem cells (LT-HSCs) are in a quiescent state during homeostasis, which is critical for their maintenance. Here, the authors show that Gal-3 expression in LT-HSCs is induced in response to Tie2 and Mpl and is both necessary and sufficient for LT-HSC quiescence through regulation of p21.
format	article
author	Weizhen Jia Lingyu Kong Hiroyasu Kidoya Hisamichi Naito Fumitaka Muramatsu Yumiko Hayashi Han-Yun Hsieh Daishi Yamakawa Daniel K. Hsu Fu-Tong Liu Nobuyuki Takakura
author_facet	Weizhen Jia Lingyu Kong Hiroyasu Kidoya Hisamichi Naito Fumitaka Muramatsu Yumiko Hayashi Han-Yun Hsieh Daishi Yamakawa Daniel K. Hsu Fu-Tong Liu Nobuyuki Takakura
author_sort	Weizhen Jia
title	Indispensable role of Galectin-3 in promoting quiescence of hematopoietic stem cells
title_short	Indispensable role of Galectin-3 in promoting quiescence of hematopoietic stem cells
title_full	Indispensable role of Galectin-3 in promoting quiescence of hematopoietic stem cells
title_fullStr	Indispensable role of Galectin-3 in promoting quiescence of hematopoietic stem cells
title_full_unstemmed	Indispensable role of Galectin-3 in promoting quiescence of hematopoietic stem cells
title_sort	indispensable role of galectin-3 in promoting quiescence of hematopoietic stem cells
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/2d73afe6425b4fe38178265b2b6f30da
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Indispensable role of Galectin-3 in promoting quiescence of hematopoietic stem cells

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