Zinc deficiency is highly prevalent and spatially dependent over short distances in Ethiopia

Abstract Zinc (Zn) is an essential nutrient for human health. In Ethiopia, a high prevalence of Zn deficiency has been reported. To explore demographic variation and spatial dependencies in the Zn status of the Ethiopian population, we analyzed archived serum samples (n = 3373) from the 2015 Ethiopi...

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Autores principales:	Adamu Belay, Dawd Gashu, Edward J. M. Joy, R. Murray Lark, Christopher Chagumaira, Blessings H. Likoswe, Dilnesaw Zerfu, E. Louise Ander, Scott D. Young, Elizabeth H. Bailey, Martin R. Broadley
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2d748ab12f754ffb88656f69afbf265e
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spelling	oai:doaj.org-article:2d748ab12f754ffb88656f69afbf265e2021-12-02T16:36:04ZZinc deficiency is highly prevalent and spatially dependent over short distances in Ethiopia10.1038/s41598-021-85977-x2045-2322https://doaj.org/article/2d748ab12f754ffb88656f69afbf265e2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-85977-xhttps://doaj.org/toc/2045-2322Abstract Zinc (Zn) is an essential nutrient for human health. In Ethiopia, a high prevalence of Zn deficiency has been reported. To explore demographic variation and spatial dependencies in the Zn status of the Ethiopian population, we analyzed archived serum samples (n = 3373) from the 2015 Ethiopian National Micronutrient Survey (ENMS), a cross-sectional survey of young children, school-age children, women of reproductive age (WRA) and men conducted in all 9 regions and two city administration of Ethiopia. Serum Zn concentrations, measured using inductively coupled plasma-mass spectrometry (ICPMS), were compared to thresholds based on age, sex, fasting status, and time of blood collection, after adjusting for inflammation status. Median serum Zn concentration of the population was 57.5 μg dL−1. Overall, it is estimated that 72% of the population was Zn deficient, with high prevalence in all demographic groups. Spatial statistical analysis showed that there was spatial dependence in Zn status of WRA at distances of up to 45 km. Zinc deficiency is spatially dependent over short distances. Although WRA in most areas are likely to be Zn deficient, prevalence of deficiency varies at regional scale and between rural and urban inhabitants, suggesting there is scope to explore drivers of this variation, prioritize nutritional interventions, and to design more representative surveillance programs.Adamu BelayDawd GashuEdward J. M. JoyR. Murray LarkChristopher ChagumairaBlessings H. LikosweDilnesaw ZerfuE. Louise AnderScott D. YoungElizabeth H. BaileyMartin R. BroadleyNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Adamu Belay Dawd Gashu Edward J. M. Joy R. Murray Lark Christopher Chagumaira Blessings H. Likoswe Dilnesaw Zerfu E. Louise Ander Scott D. Young Elizabeth H. Bailey Martin R. Broadley Zinc deficiency is highly prevalent and spatially dependent over short distances in Ethiopia
description	Abstract Zinc (Zn) is an essential nutrient for human health. In Ethiopia, a high prevalence of Zn deficiency has been reported. To explore demographic variation and spatial dependencies in the Zn status of the Ethiopian population, we analyzed archived serum samples (n = 3373) from the 2015 Ethiopian National Micronutrient Survey (ENMS), a cross-sectional survey of young children, school-age children, women of reproductive age (WRA) and men conducted in all 9 regions and two city administration of Ethiopia. Serum Zn concentrations, measured using inductively coupled plasma-mass spectrometry (ICPMS), were compared to thresholds based on age, sex, fasting status, and time of blood collection, after adjusting for inflammation status. Median serum Zn concentration of the population was 57.5 μg dL−1. Overall, it is estimated that 72% of the population was Zn deficient, with high prevalence in all demographic groups. Spatial statistical analysis showed that there was spatial dependence in Zn status of WRA at distances of up to 45 km. Zinc deficiency is spatially dependent over short distances. Although WRA in most areas are likely to be Zn deficient, prevalence of deficiency varies at regional scale and between rural and urban inhabitants, suggesting there is scope to explore drivers of this variation, prioritize nutritional interventions, and to design more representative surveillance programs.
format	article
author	Adamu Belay Dawd Gashu Edward J. M. Joy R. Murray Lark Christopher Chagumaira Blessings H. Likoswe Dilnesaw Zerfu E. Louise Ander Scott D. Young Elizabeth H. Bailey Martin R. Broadley
author_facet	Adamu Belay Dawd Gashu Edward J. M. Joy R. Murray Lark Christopher Chagumaira Blessings H. Likoswe Dilnesaw Zerfu E. Louise Ander Scott D. Young Elizabeth H. Bailey Martin R. Broadley
author_sort	Adamu Belay
title	Zinc deficiency is highly prevalent and spatially dependent over short distances in Ethiopia
title_short	Zinc deficiency is highly prevalent and spatially dependent over short distances in Ethiopia
title_full	Zinc deficiency is highly prevalent and spatially dependent over short distances in Ethiopia
title_fullStr	Zinc deficiency is highly prevalent and spatially dependent over short distances in Ethiopia
title_full_unstemmed	Zinc deficiency is highly prevalent and spatially dependent over short distances in Ethiopia
title_sort	zinc deficiency is highly prevalent and spatially dependent over short distances in ethiopia
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/2d748ab12f754ffb88656f69afbf265e
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Zinc deficiency is highly prevalent and spatially dependent over short distances in Ethiopia

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