Induction of hair growth by insulin-like growth factor-1 in 1,763 MHz radiofrequency-irradiated hair follicle cells.

Radiofrequency (RF) radiation does not transfer high energy to break the covalent bonds of macromolecules, but these low energy stimuli might be sufficient to induce molecular responses in a specific manner. We monitored the effect of 1,763 MHz RF radiation on cultured human dermal papilla cells (hD...

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Autores principales:	Sun-Young Yoon, Kyu-Tae Kim, Seong Jin Jo, A-Ri Cho, Soon-Ik Jeon, Hyung-Do Choi, Kyu Han Kim, Gun-Sik Park, Jeong-Ki Pack, Oh Sang Kwon, Woong-Yang Park
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2d769b2a0337413ea311eb87dcebc777
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spelling	oai:doaj.org-article:2d769b2a0337413ea311eb87dcebc7772021-11-18T07:33:05ZInduction of hair growth by insulin-like growth factor-1 in 1,763 MHz radiofrequency-irradiated hair follicle cells.1932-620310.1371/journal.pone.0028474https://doaj.org/article/2d769b2a0337413ea311eb87dcebc7772011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22164296/?tool=EBIhttps://doaj.org/toc/1932-6203Radiofrequency (RF) radiation does not transfer high energy to break the covalent bonds of macromolecules, but these low energy stimuli might be sufficient to induce molecular responses in a specific manner. We monitored the effect of 1,763 MHz RF radiation on cultured human dermal papilla cells (hDPCs) by evaluating changes in the expression of cytokines related to hair growth. The expression of insulin-like growth factor-1 (IGF-1) mRNA in hDPCs was significantly induced upon RF radiation at the specific absorption rate of 10 W/kg, which resulted in increased expression of B-cell chronic lymphocytic leukemia/lymphoma 2 (BCL-2) and cyclin D1 (CCND1) proteins and increased phosphorylation of MAPK1 protein. Exposure to 10 W/kg RF radiation 1 h per day for 7 days significantly enhanced hair shaft elongation in ex vivo hair organ cultures. In RF-exposed follicular matrix keratinocytes in the hair bulb, the expression of Ki-67 was increased, while the signal for terminal deoxynucleotidyl transferase dUTP nick end labeling was reduced. From these results, we suggest that 1,763 MHz RF exposure stimulates hair growth in vitro through the induction of IGF-1 in hDPCs.Sun-Young YoonKyu-Tae KimSeong Jin JoA-Ri ChoSoon-Ik JeonHyung-Do ChoiKyu Han KimGun-Sik ParkJeong-Ki PackOh Sang KwonWoong-Yang ParkPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 12, p e28474 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sun-Young Yoon Kyu-Tae Kim Seong Jin Jo A-Ri Cho Soon-Ik Jeon Hyung-Do Choi Kyu Han Kim Gun-Sik Park Jeong-Ki Pack Oh Sang Kwon Woong-Yang Park Induction of hair growth by insulin-like growth factor-1 in 1,763 MHz radiofrequency-irradiated hair follicle cells.
description	Radiofrequency (RF) radiation does not transfer high energy to break the covalent bonds of macromolecules, but these low energy stimuli might be sufficient to induce molecular responses in a specific manner. We monitored the effect of 1,763 MHz RF radiation on cultured human dermal papilla cells (hDPCs) by evaluating changes in the expression of cytokines related to hair growth. The expression of insulin-like growth factor-1 (IGF-1) mRNA in hDPCs was significantly induced upon RF radiation at the specific absorption rate of 10 W/kg, which resulted in increased expression of B-cell chronic lymphocytic leukemia/lymphoma 2 (BCL-2) and cyclin D1 (CCND1) proteins and increased phosphorylation of MAPK1 protein. Exposure to 10 W/kg RF radiation 1 h per day for 7 days significantly enhanced hair shaft elongation in ex vivo hair organ cultures. In RF-exposed follicular matrix keratinocytes in the hair bulb, the expression of Ki-67 was increased, while the signal for terminal deoxynucleotidyl transferase dUTP nick end labeling was reduced. From these results, we suggest that 1,763 MHz RF exposure stimulates hair growth in vitro through the induction of IGF-1 in hDPCs.
format	article
author	Sun-Young Yoon Kyu-Tae Kim Seong Jin Jo A-Ri Cho Soon-Ik Jeon Hyung-Do Choi Kyu Han Kim Gun-Sik Park Jeong-Ki Pack Oh Sang Kwon Woong-Yang Park
author_facet	Sun-Young Yoon Kyu-Tae Kim Seong Jin Jo A-Ri Cho Soon-Ik Jeon Hyung-Do Choi Kyu Han Kim Gun-Sik Park Jeong-Ki Pack Oh Sang Kwon Woong-Yang Park
author_sort	Sun-Young Yoon
title	Induction of hair growth by insulin-like growth factor-1 in 1,763 MHz radiofrequency-irradiated hair follicle cells.
title_short	Induction of hair growth by insulin-like growth factor-1 in 1,763 MHz radiofrequency-irradiated hair follicle cells.
title_full	Induction of hair growth by insulin-like growth factor-1 in 1,763 MHz radiofrequency-irradiated hair follicle cells.
title_fullStr	Induction of hair growth by insulin-like growth factor-1 in 1,763 MHz radiofrequency-irradiated hair follicle cells.
title_full_unstemmed	Induction of hair growth by insulin-like growth factor-1 in 1,763 MHz radiofrequency-irradiated hair follicle cells.
title_sort	induction of hair growth by insulin-like growth factor-1 in 1,763 mhz radiofrequency-irradiated hair follicle cells.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/2d769b2a0337413ea311eb87dcebc777
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Induction of hair growth by insulin-like growth factor-1 in 1,763 MHz radiofrequency-irradiated hair follicle cells.

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