Stephan Oroszlan and the Proteolytic Processing of Retroviral Proteins: Following A Pro

Steve Oroszlan determined the sequences at the ends of virion proteins for a number of different retroviruses. This work led to the insight that the amino-terminal amino acid of the mature viral CA protein is always proline. In this remembrance, we review Steve’s work that led to this insight and sh...

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Autores principales:	Ronald Swanstrom, Wesley I. Sundquist
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	Oroszlan retroviruses HIV-1 protease capsid Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/2d76e02f51164c92af5b9bafc7cba578
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spelling	oai:doaj.org-article:2d76e02f51164c92af5b9bafc7cba5782021-11-25T19:13:26ZStephan Oroszlan and the Proteolytic Processing of Retroviral Proteins: Following A Pro10.3390/v131122181999-4915https://doaj.org/article/2d76e02f51164c92af5b9bafc7cba5782021-11-01T00:00:00Zhttps://www.mdpi.com/1999-4915/13/11/2218https://doaj.org/toc/1999-4915Steve Oroszlan determined the sequences at the ends of virion proteins for a number of different retroviruses. This work led to the insight that the amino-terminal amino acid of the mature viral CA protein is always proline. In this remembrance, we review Steve’s work that led to this insight and show how that insight was a necessary precursor to the work we have done in the subsequent years exploring the cleavage rate determinants of viral protease processing sites and the multiple roles the amino-terminal proline of CA plays after protease cleavage liberates it from its position in a protease processing site.Ronald SwanstromWesley I. SundquistMDPI AGarticleOroszlanretrovirusesHIV-1proteasecapsidMicrobiologyQR1-502ENViruses, Vol 13, Iss 2218, p 2218 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Oroszlan retroviruses HIV-1 protease capsid Microbiology QR1-502
spellingShingle	Oroszlan retroviruses HIV-1 protease capsid Microbiology QR1-502 Ronald Swanstrom Wesley I. Sundquist Stephan Oroszlan and the Proteolytic Processing of Retroviral Proteins: Following A Pro
description	Steve Oroszlan determined the sequences at the ends of virion proteins for a number of different retroviruses. This work led to the insight that the amino-terminal amino acid of the mature viral CA protein is always proline. In this remembrance, we review Steve’s work that led to this insight and show how that insight was a necessary precursor to the work we have done in the subsequent years exploring the cleavage rate determinants of viral protease processing sites and the multiple roles the amino-terminal proline of CA plays after protease cleavage liberates it from its position in a protease processing site.
format	article
author	Ronald Swanstrom Wesley I. Sundquist
author_facet	Ronald Swanstrom Wesley I. Sundquist
author_sort	Ronald Swanstrom
title	Stephan Oroszlan and the Proteolytic Processing of Retroviral Proteins: Following A Pro
title_short	Stephan Oroszlan and the Proteolytic Processing of Retroviral Proteins: Following A Pro
title_full	Stephan Oroszlan and the Proteolytic Processing of Retroviral Proteins: Following A Pro
title_fullStr	Stephan Oroszlan and the Proteolytic Processing of Retroviral Proteins: Following A Pro
title_full_unstemmed	Stephan Oroszlan and the Proteolytic Processing of Retroviral Proteins: Following A Pro
title_sort	stephan oroszlan and the proteolytic processing of retroviral proteins: following a pro
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/2d76e02f51164c92af5b9bafc7cba578
work_keys_str_mv	AT ronaldswanstrom stephanoroszlanandtheproteolyticprocessingofretroviralproteinsfollowingapro AT wesleyisundquist stephanoroszlanandtheproteolyticprocessingofretroviralproteinsfollowingapro
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Stephan Oroszlan and the Proteolytic Processing of Retroviral Proteins: Following A Pro

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