Multi-faceted epigenetic dysregulation of gene expression promotes esophageal squamous cell carcinoma
The epigenetic landscape of esophageal squamous cell carcinoma (ESCC) at genome-wide high resolution is incompletely studied. Here, the authors performed an integrated multi-omics analysis of ESCC and non-tumor tissues to define the genome-wide methylome landscape and epigenetic alterations to uncov...
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Nature Portfolio
2020
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oai:doaj.org-article:2d7895e7d5f748e48174da98ff21c5312021-12-02T16:26:32ZMulti-faceted epigenetic dysregulation of gene expression promotes esophageal squamous cell carcinoma10.1038/s41467-020-17227-z2041-1723https://doaj.org/article/2d7895e7d5f748e48174da98ff21c5312020-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17227-zhttps://doaj.org/toc/2041-1723The epigenetic landscape of esophageal squamous cell carcinoma (ESCC) at genome-wide high resolution is incompletely studied. Here, the authors performed an integrated multi-omics analysis of ESCC and non-tumor tissues to define the genome-wide methylome landscape and epigenetic alterations to uncover oncogenic drivers of ESCC.Wei CaoHayan LeeWei WuAubhishek ZamanSean McCorkleMing YanJustin ChenQinghe XingNasa Sinnott-ArmstrongHongen XuM. Reza SailaniWenxue TangYuanbo CuiJia liuHongyan GuanPengju LvXiaoyan SunLei SunPengli HanYanan LouJing ChangJinwu WangYuchi GaoJiancheng GuoGundolf SchenkAlan Hunter ShainFred G. BiddleEric CollissonMichael SnyderTrever G. BivonaNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-19 (2020) |
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DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Wei Cao Hayan Lee Wei Wu Aubhishek Zaman Sean McCorkle Ming Yan Justin Chen Qinghe Xing Nasa Sinnott-Armstrong Hongen Xu M. Reza Sailani Wenxue Tang Yuanbo Cui Jia liu Hongyan Guan Pengju Lv Xiaoyan Sun Lei Sun Pengli Han Yanan Lou Jing Chang Jinwu Wang Yuchi Gao Jiancheng Guo Gundolf Schenk Alan Hunter Shain Fred G. Biddle Eric Collisson Michael Snyder Trever G. Bivona Multi-faceted epigenetic dysregulation of gene expression promotes esophageal squamous cell carcinoma |
| description |
The epigenetic landscape of esophageal squamous cell carcinoma (ESCC) at genome-wide high resolution is incompletely studied. Here, the authors performed an integrated multi-omics analysis of ESCC and non-tumor tissues to define the genome-wide methylome landscape and epigenetic alterations to uncover oncogenic drivers of ESCC. |
| format |
article |
| author |
Wei Cao Hayan Lee Wei Wu Aubhishek Zaman Sean McCorkle Ming Yan Justin Chen Qinghe Xing Nasa Sinnott-Armstrong Hongen Xu M. Reza Sailani Wenxue Tang Yuanbo Cui Jia liu Hongyan Guan Pengju Lv Xiaoyan Sun Lei Sun Pengli Han Yanan Lou Jing Chang Jinwu Wang Yuchi Gao Jiancheng Guo Gundolf Schenk Alan Hunter Shain Fred G. Biddle Eric Collisson Michael Snyder Trever G. Bivona |
| author_facet |
Wei Cao Hayan Lee Wei Wu Aubhishek Zaman Sean McCorkle Ming Yan Justin Chen Qinghe Xing Nasa Sinnott-Armstrong Hongen Xu M. Reza Sailani Wenxue Tang Yuanbo Cui Jia liu Hongyan Guan Pengju Lv Xiaoyan Sun Lei Sun Pengli Han Yanan Lou Jing Chang Jinwu Wang Yuchi Gao Jiancheng Guo Gundolf Schenk Alan Hunter Shain Fred G. Biddle Eric Collisson Michael Snyder Trever G. Bivona |
| author_sort |
Wei Cao |
| title |
Multi-faceted epigenetic dysregulation of gene expression promotes esophageal squamous cell carcinoma |
| title_short |
Multi-faceted epigenetic dysregulation of gene expression promotes esophageal squamous cell carcinoma |
| title_full |
Multi-faceted epigenetic dysregulation of gene expression promotes esophageal squamous cell carcinoma |
| title_fullStr |
Multi-faceted epigenetic dysregulation of gene expression promotes esophageal squamous cell carcinoma |
| title_full_unstemmed |
Multi-faceted epigenetic dysregulation of gene expression promotes esophageal squamous cell carcinoma |
| title_sort |
multi-faceted epigenetic dysregulation of gene expression promotes esophageal squamous cell carcinoma |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/2d7895e7d5f748e48174da98ff21c531 |
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