Role of backbone strain in de novo design of complex α/β protein structures

The authors show that consideration of global backbone strain enables successful de novo design of larger αβ-proteins with five- and six- stranded β-sheets flanked by α-helices.

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Autores principales:	Nobuyasu Koga, Rie Koga, Gaohua Liu, Javier Castellanos, Gaetano T. Montelione, David Baker
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2d79dbe5ccf94845993306b13efb4de2
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spelling	oai:doaj.org-article:2d79dbe5ccf94845993306b13efb4de22021-12-02T16:05:50ZRole of backbone strain in de novo design of complex α/β protein structures10.1038/s41467-021-24050-72041-1723https://doaj.org/article/2d79dbe5ccf94845993306b13efb4de22021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24050-7https://doaj.org/toc/2041-1723The authors show that consideration of global backbone strain enables successful de novo design of larger αβ-proteins with five- and six- stranded β-sheets flanked by α-helices.Nobuyasu KogaRie KogaGaohua LiuJavier CastellanosGaetano T. MontelioneDavid BakerNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Nobuyasu Koga Rie Koga Gaohua Liu Javier Castellanos Gaetano T. Montelione David Baker Role of backbone strain in de novo design of complex α/β protein structures
description	The authors show that consideration of global backbone strain enables successful de novo design of larger αβ-proteins with five- and six- stranded β-sheets flanked by α-helices.
format	article
author	Nobuyasu Koga Rie Koga Gaohua Liu Javier Castellanos Gaetano T. Montelione David Baker
author_facet	Nobuyasu Koga Rie Koga Gaohua Liu Javier Castellanos Gaetano T. Montelione David Baker
author_sort	Nobuyasu Koga
title	Role of backbone strain in de novo design of complex α/β protein structures
title_short	Role of backbone strain in de novo design of complex α/β protein structures
title_full	Role of backbone strain in de novo design of complex α/β protein structures
title_fullStr	Role of backbone strain in de novo design of complex α/β protein structures
title_full_unstemmed	Role of backbone strain in de novo design of complex α/β protein structures
title_sort	role of backbone strain in de novo design of complex α/β protein structures
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/2d79dbe5ccf94845993306b13efb4de2
work_keys_str_mv	AT nobuyasukoga roleofbackbonestrainindenovodesignofcomplexabproteinstructures AT riekoga roleofbackbonestrainindenovodesignofcomplexabproteinstructures AT gaohualiu roleofbackbonestrainindenovodesignofcomplexabproteinstructures AT javiercastellanos roleofbackbonestrainindenovodesignofcomplexabproteinstructures AT gaetanotmontelione roleofbackbonestrainindenovodesignofcomplexabproteinstructures AT davidbaker roleofbackbonestrainindenovodesignofcomplexabproteinstructures
_version_	1718385137438162944

Role of backbone strain in de novo design of complex α/β protein structures

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