Cognitive Development and Brain Gray Matter Susceptibility to Prenatal Adversities: Moderation by the Prefrontal Cortex Brain-Derived Neurotrophic Factor Gene Co-expression Network

Background: Previous studies focused on the relationship between prenatal conditions and neurodevelopmental outcomes later in life, but few have explored the interplay between gene co-expression networks and prenatal adversity conditions on cognitive development trajectories and gray matter density....

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Autores principales:	Euclides José de Mendonça Filho, Barbara Barth, Denise Ruschel Bandeira, Randriely Merscher Sobreira de Lima, Danusa Mar Arcego, Carla Dalmaz, Irina Pokhvisneva, Roberto Britto Sassi, Geoffrey B. C. Hall, Michael J. Meaney, Patricia Pelufo Silveira
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	BDNF polygenic score prenatal adversity cognitive development gray matter Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/2d7aea37715d4a18bd82d926e9bbe315
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spelling	oai:doaj.org-article:2d7aea37715d4a18bd82d926e9bbe3152021-11-30T19:18:19ZCognitive Development and Brain Gray Matter Susceptibility to Prenatal Adversities: Moderation by the Prefrontal Cortex Brain-Derived Neurotrophic Factor Gene Co-expression Network1662-453X10.3389/fnins.2021.744743https://doaj.org/article/2d7aea37715d4a18bd82d926e9bbe3152021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fnins.2021.744743/fullhttps://doaj.org/toc/1662-453XBackground: Previous studies focused on the relationship between prenatal conditions and neurodevelopmental outcomes later in life, but few have explored the interplay between gene co-expression networks and prenatal adversity conditions on cognitive development trajectories and gray matter density.Methods: We analyzed the moderation effects of an expression polygenic score (ePRS) for the Brain-derived Neurotrophic Factor gene network (BDNF ePRS) on the association between prenatal adversity and child cognitive development. A score based on genes co-expressed with the prefrontal cortex (PFC) BDNF was created, using the effect size of the association between the individual single nucleotide polymorphisms (SNP) and the BDNF expression in the PFC. Cognitive development trajectories of 157 young children from the Maternal Adversity, Vulnerability and Neurodevelopment (MAVAN) cohort were assessed longitudinally in 4-time points (6, 12, 18, and 36 months) using the Bayley-II mental scales.Results: Linear mixed-effects modeling indicated that BDNF ePRS moderates the effects of prenatal adversity on cognitive growth. In children with high BDNF ePRS, higher prenatal adversity was associated with slower cognitive development in comparison with those exposed to lower prenatal adversity. Parallel-Independent Component Analysis (pICA) suggested that associations of expression-based SNPs and gray matter density significantly differed between low and high prenatal adversity groups. The brain IC included areas involved in visual association processes (Brodmann area 19 and 18), reallocation of attention, and integration of information across the supramodal cortex (Brodmann area 10).Conclusion: Cognitive development trajectories and brain gray matter seem to be influenced by the interplay of prenatal environmental conditions and the expression of an important BDNF gene network that guides the growth and plasticity of neurons and synapses.Euclides José de Mendonça FilhoEuclides José de Mendonça FilhoBarbara BarthBarbara BarthDenise Ruschel BandeiraRandriely Merscher Sobreira de LimaRandriely Merscher Sobreira de LimaRandriely Merscher Sobreira de LimaDanusa Mar ArcegoDanusa Mar ArcegoCarla DalmazIrina PokhvisnevaRoberto Britto SassiGeoffrey B. C. HallMichael J. MeaneyMichael J. MeaneyMichael J. MeaneyPatricia Pelufo SilveiraPatricia Pelufo SilveiraFrontiers Media S.A.articleBDNFpolygenic scoreprenatal adversitycognitive developmentgray matterNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENFrontiers in Neuroscience, Vol 15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	BDNF polygenic score prenatal adversity cognitive development gray matter Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	BDNF polygenic score prenatal adversity cognitive development gray matter Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Euclides José de Mendonça Filho Euclides José de Mendonça Filho Barbara Barth Barbara Barth Denise Ruschel Bandeira Randriely Merscher Sobreira de Lima Randriely Merscher Sobreira de Lima Randriely Merscher Sobreira de Lima Danusa Mar Arcego Danusa Mar Arcego Carla Dalmaz Irina Pokhvisneva Roberto Britto Sassi Geoffrey B. C. Hall Michael J. Meaney Michael J. Meaney Michael J. Meaney Patricia Pelufo Silveira Patricia Pelufo Silveira Cognitive Development and Brain Gray Matter Susceptibility to Prenatal Adversities: Moderation by the Prefrontal Cortex Brain-Derived Neurotrophic Factor Gene Co-expression Network
description	Background: Previous studies focused on the relationship between prenatal conditions and neurodevelopmental outcomes later in life, but few have explored the interplay between gene co-expression networks and prenatal adversity conditions on cognitive development trajectories and gray matter density.Methods: We analyzed the moderation effects of an expression polygenic score (ePRS) for the Brain-derived Neurotrophic Factor gene network (BDNF ePRS) on the association between prenatal adversity and child cognitive development. A score based on genes co-expressed with the prefrontal cortex (PFC) BDNF was created, using the effect size of the association between the individual single nucleotide polymorphisms (SNP) and the BDNF expression in the PFC. Cognitive development trajectories of 157 young children from the Maternal Adversity, Vulnerability and Neurodevelopment (MAVAN) cohort were assessed longitudinally in 4-time points (6, 12, 18, and 36 months) using the Bayley-II mental scales.Results: Linear mixed-effects modeling indicated that BDNF ePRS moderates the effects of prenatal adversity on cognitive growth. In children with high BDNF ePRS, higher prenatal adversity was associated with slower cognitive development in comparison with those exposed to lower prenatal adversity. Parallel-Independent Component Analysis (pICA) suggested that associations of expression-based SNPs and gray matter density significantly differed between low and high prenatal adversity groups. The brain IC included areas involved in visual association processes (Brodmann area 19 and 18), reallocation of attention, and integration of information across the supramodal cortex (Brodmann area 10).Conclusion: Cognitive development trajectories and brain gray matter seem to be influenced by the interplay of prenatal environmental conditions and the expression of an important BDNF gene network that guides the growth and plasticity of neurons and synapses.
format	article
author	Euclides José de Mendonça Filho Euclides José de Mendonça Filho Barbara Barth Barbara Barth Denise Ruschel Bandeira Randriely Merscher Sobreira de Lima Randriely Merscher Sobreira de Lima Randriely Merscher Sobreira de Lima Danusa Mar Arcego Danusa Mar Arcego Carla Dalmaz Irina Pokhvisneva Roberto Britto Sassi Geoffrey B. C. Hall Michael J. Meaney Michael J. Meaney Michael J. Meaney Patricia Pelufo Silveira Patricia Pelufo Silveira
author_facet	Euclides José de Mendonça Filho Euclides José de Mendonça Filho Barbara Barth Barbara Barth Denise Ruschel Bandeira Randriely Merscher Sobreira de Lima Randriely Merscher Sobreira de Lima Randriely Merscher Sobreira de Lima Danusa Mar Arcego Danusa Mar Arcego Carla Dalmaz Irina Pokhvisneva Roberto Britto Sassi Geoffrey B. C. Hall Michael J. Meaney Michael J. Meaney Michael J. Meaney Patricia Pelufo Silveira Patricia Pelufo Silveira
author_sort	Euclides José de Mendonça Filho
title	Cognitive Development and Brain Gray Matter Susceptibility to Prenatal Adversities: Moderation by the Prefrontal Cortex Brain-Derived Neurotrophic Factor Gene Co-expression Network
title_short	Cognitive Development and Brain Gray Matter Susceptibility to Prenatal Adversities: Moderation by the Prefrontal Cortex Brain-Derived Neurotrophic Factor Gene Co-expression Network
title_full	Cognitive Development and Brain Gray Matter Susceptibility to Prenatal Adversities: Moderation by the Prefrontal Cortex Brain-Derived Neurotrophic Factor Gene Co-expression Network
title_fullStr	Cognitive Development and Brain Gray Matter Susceptibility to Prenatal Adversities: Moderation by the Prefrontal Cortex Brain-Derived Neurotrophic Factor Gene Co-expression Network
title_full_unstemmed	Cognitive Development and Brain Gray Matter Susceptibility to Prenatal Adversities: Moderation by the Prefrontal Cortex Brain-Derived Neurotrophic Factor Gene Co-expression Network
title_sort	cognitive development and brain gray matter susceptibility to prenatal adversities: moderation by the prefrontal cortex brain-derived neurotrophic factor gene co-expression network
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/2d7aea37715d4a18bd82d926e9bbe315
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Cognitive Development and Brain Gray Matter Susceptibility to Prenatal Adversities: Moderation by the Prefrontal Cortex Brain-Derived Neurotrophic Factor Gene Co-expression Network

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