Acute neuropsychiatric disorders in adolescents and young adults with Down syndrome: Japanese case reports

Keiko Akahoshi,1 Hiroshi Matsuda,2 Masuko Funahashi,1 Tomoyuki Hanaoka,3 Yasuyuki Suzuki11Department of Pediatrics, Tokyo Children&rsquo;s Rehabilitation Hospital, Tokyo; 2Department of Nuclear Medicine, Saitama Medical University, International Medical Center, Saitama; 3Department of Pediat...

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Autores principales:	Akahoshi K, Matsuda H, Funahashi M, Hanaoka T, Suzuki Y
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2012
Materias:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/2d7b0b2db9ce4d0bb53ac9352b156442
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spelling	oai:doaj.org-article:2d7b0b2db9ce4d0bb53ac9352b1564422021-12-02T07:17:44ZAcute neuropsychiatric disorders in adolescents and young adults with Down syndrome: Japanese case reports1176-63281178-2021https://doaj.org/article/2d7b0b2db9ce4d0bb53ac9352b1564422012-07-01T00:00:00Zhttp://www.dovepress.com/acute-neuropsychiatric-disorders-in-adolescents-and-young-adults-with--a10557https://doaj.org/toc/1176-6328https://doaj.org/toc/1178-2021Keiko Akahoshi,1 Hiroshi Matsuda,2 Masuko Funahashi,1 Tomoyuki Hanaoka,3 Yasuyuki Suzuki11Department of Pediatrics, Tokyo Children&rsquo;s Rehabilitation Hospital, Tokyo; 2Department of Nuclear Medicine, Saitama Medical University, International Medical Center, Saitama; 3Department of Pediatrics, Bihoro Rehabilitation Hospital, Hokkaido, JapanBackground: The aim of this study was to evaluate acute neuropsychiatric disorders in adolescents and young adults with Down syndrome. We report 13 Japanese adolescents or young adults with Down syndrome who developed acute neuropsychiatric disorders including withdrawal, depression, obsessive-compulsive behaviors, and occasional delusions or hallucinations.Methods: The following information was collected from each patient: age at onset of acute neuropsychiatric disorder, complications, signs and symptoms, personality traits before the onset of the acute neuropsychiatric disorder, prescribed medications with their respective doses and the response to treatment, and senile changes observed on magnetic resonance imaging or computed tomography.Results: The mean age at onset of these disorders was 21.2 years. Brain imaging showed almost senile changes; patients responded well to low-dose psychotropic therapy. Patients had an onset at a young age and presented with treatable conditions, although the average age of the onset of Alzheimer&rsquo;s disease is generally over 40 years of age in patients with Down syndrome.Conclusion: These findings suggest that the pathology of acute neuropsychiatric disorder in patients with Down syndrome may be related to presenile changes; however, these disorders present features and a clinical course that is different from those presented in typical Alzheimer&rsquo;s disease with Down syndrome.Keywords: Down syndrome, acute neuropsychiatric disorders, Alzheimer&rsquo;s diseaseAkahoshi KMatsuda HFunahashi MHanaoka TSuzuki YDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2012, Iss default, Pp 339-345 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Akahoshi K Matsuda H Funahashi M Hanaoka T Suzuki Y Acute neuropsychiatric disorders in adolescents and young adults with Down syndrome: Japanese case reports
description	Keiko Akahoshi,1 Hiroshi Matsuda,2 Masuko Funahashi,1 Tomoyuki Hanaoka,3 Yasuyuki Suzuki11Department of Pediatrics, Tokyo Children&rsquo;s Rehabilitation Hospital, Tokyo; 2Department of Nuclear Medicine, Saitama Medical University, International Medical Center, Saitama; 3Department of Pediatrics, Bihoro Rehabilitation Hospital, Hokkaido, JapanBackground: The aim of this study was to evaluate acute neuropsychiatric disorders in adolescents and young adults with Down syndrome. We report 13 Japanese adolescents or young adults with Down syndrome who developed acute neuropsychiatric disorders including withdrawal, depression, obsessive-compulsive behaviors, and occasional delusions or hallucinations.Methods: The following information was collected from each patient: age at onset of acute neuropsychiatric disorder, complications, signs and symptoms, personality traits before the onset of the acute neuropsychiatric disorder, prescribed medications with their respective doses and the response to treatment, and senile changes observed on magnetic resonance imaging or computed tomography.Results: The mean age at onset of these disorders was 21.2 years. Brain imaging showed almost senile changes; patients responded well to low-dose psychotropic therapy. Patients had an onset at a young age and presented with treatable conditions, although the average age of the onset of Alzheimer&rsquo;s disease is generally over 40 years of age in patients with Down syndrome.Conclusion: These findings suggest that the pathology of acute neuropsychiatric disorder in patients with Down syndrome may be related to presenile changes; however, these disorders present features and a clinical course that is different from those presented in typical Alzheimer&rsquo;s disease with Down syndrome.Keywords: Down syndrome, acute neuropsychiatric disorders, Alzheimer&rsquo;s disease
format	article
author	Akahoshi K Matsuda H Funahashi M Hanaoka T Suzuki Y
author_facet	Akahoshi K Matsuda H Funahashi M Hanaoka T Suzuki Y
author_sort	Akahoshi K
title	Acute neuropsychiatric disorders in adolescents and young adults with Down syndrome: Japanese case reports
title_short	Acute neuropsychiatric disorders in adolescents and young adults with Down syndrome: Japanese case reports
title_full	Acute neuropsychiatric disorders in adolescents and young adults with Down syndrome: Japanese case reports
title_fullStr	Acute neuropsychiatric disorders in adolescents and young adults with Down syndrome: Japanese case reports
title_full_unstemmed	Acute neuropsychiatric disorders in adolescents and young adults with Down syndrome: Japanese case reports
title_sort	acute neuropsychiatric disorders in adolescents and young adults with down syndrome: japanese case reports
publisher	Dove Medical Press
publishDate	2012
url	https://doaj.org/article/2d7b0b2db9ce4d0bb53ac9352b156442
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Acute neuropsychiatric disorders in adolescents and young adults with Down syndrome: Japanese case reports

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