Autophosphorylation at serine 166 regulates RIP kinase 1-mediated cell death and inflammation

Autophosphorylation at serine 166 regulates RIP kinase 1-mediated cell death and inflammation

Receptor interacting protein kinase 1 (RIPK1) regulates cell death and inflammatory responses. Here the authors show that autophosphorylation at Ser166 is required for RIPK1-mediated cell death and inflammation in mouse models of inflammatory pathologies, making Ser166 phosphorylation a possible bio...

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Main Authors: Lucie Laurien, Masahiro Nagata, Hannah Schünke, Tom Delanghe, Janica L. Wiederstein, Snehlata Kumari, Robin Schwarzer, Teresa Corona, Marcus Krüger, Mathieu J. M. Bertrand, Vangelis Kondylis, Manolis Pasparakis
Format: article
Language:EN
Published: Nature Portfolio 2020
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Science
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Online Access:https://doaj.org/article/2d82135048944fbfa5ea87adae76d9b0
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https://doaj.org/article/2d82135048944fbfa5ea87adae76d9b0

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