Lactic acid as a major contributor to hand surface infection barrier and its association with morbidity to infectious disease

Abstract Although the surface of the human hands contains high antimicrobial activity, studies investigating the precise components involved and the relationship between natural antimicrobial activity and morbidity in infectious diseases are limited. In this study, we developed a method to quantitat...

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Autores principales:	Yuki Nishioka, Kenichi Nagano, Yoshitaka Koga, Yasuhiro Okada, Ichiro Mori, Atsuko Hayase, Takuya Mori, Kenji Manabe
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2d82759813b346de9125e1cd6b87e177
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spelling	oai:doaj.org-article:2d82759813b346de9125e1cd6b87e1772021-12-02T18:13:45ZLactic acid as a major contributor to hand surface infection barrier and its association with morbidity to infectious disease10.1038/s41598-021-98042-42045-2322https://doaj.org/article/2d82759813b346de9125e1cd6b87e1772021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-98042-4https://doaj.org/toc/2045-2322Abstract Although the surface of the human hands contains high antimicrobial activity, studies investigating the precise components involved and the relationship between natural antimicrobial activity and morbidity in infectious diseases are limited. In this study, we developed a method to quantitatively measure the antimicrobial activity of hand surface components. Using a clinical survey, we validated the feasibility of our method and identified antimicrobial factors on the surface of the human hand. In a retrospective observational study, we compared the medical histories of the participants to assess infectious diseases. We found that the antimicrobial activity on the surface of the hands was significantly lower in the high morbidity group (N = 55) than in the low morbidity group (N = 54), indicating a positive association with the history of infection in individuals. A comprehensive analysis of the hand surface components indicated that organic acids, especially lactic acid and antimicrobial peptides, are highly correlated with antimicrobial activity. Moreover, the application of lactic acid using the amount present on the surface of the hand significantly improved the antimicrobial activity. These findings suggest that hand hygiene must be improved to enhance natural antimicrobial activity on the surface of the hands.Yuki NishiokaKenichi NaganoYoshitaka KogaYasuhiro OkadaIchiro MoriAtsuko HayaseTakuya MoriKenji ManabeNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yuki Nishioka Kenichi Nagano Yoshitaka Koga Yasuhiro Okada Ichiro Mori Atsuko Hayase Takuya Mori Kenji Manabe Lactic acid as a major contributor to hand surface infection barrier and its association with morbidity to infectious disease
description	Abstract Although the surface of the human hands contains high antimicrobial activity, studies investigating the precise components involved and the relationship between natural antimicrobial activity and morbidity in infectious diseases are limited. In this study, we developed a method to quantitatively measure the antimicrobial activity of hand surface components. Using a clinical survey, we validated the feasibility of our method and identified antimicrobial factors on the surface of the human hand. In a retrospective observational study, we compared the medical histories of the participants to assess infectious diseases. We found that the antimicrobial activity on the surface of the hands was significantly lower in the high morbidity group (N = 55) than in the low morbidity group (N = 54), indicating a positive association with the history of infection in individuals. A comprehensive analysis of the hand surface components indicated that organic acids, especially lactic acid and antimicrobial peptides, are highly correlated with antimicrobial activity. Moreover, the application of lactic acid using the amount present on the surface of the hand significantly improved the antimicrobial activity. These findings suggest that hand hygiene must be improved to enhance natural antimicrobial activity on the surface of the hands.
format	article
author	Yuki Nishioka Kenichi Nagano Yoshitaka Koga Yasuhiro Okada Ichiro Mori Atsuko Hayase Takuya Mori Kenji Manabe
author_facet	Yuki Nishioka Kenichi Nagano Yoshitaka Koga Yasuhiro Okada Ichiro Mori Atsuko Hayase Takuya Mori Kenji Manabe
author_sort	Yuki Nishioka
title	Lactic acid as a major contributor to hand surface infection barrier and its association with morbidity to infectious disease
title_short	Lactic acid as a major contributor to hand surface infection barrier and its association with morbidity to infectious disease
title_full	Lactic acid as a major contributor to hand surface infection barrier and its association with morbidity to infectious disease
title_fullStr	Lactic acid as a major contributor to hand surface infection barrier and its association with morbidity to infectious disease
title_full_unstemmed	Lactic acid as a major contributor to hand surface infection barrier and its association with morbidity to infectious disease
title_sort	lactic acid as a major contributor to hand surface infection barrier and its association with morbidity to infectious disease
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/2d82759813b346de9125e1cd6b87e177
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Lactic acid as a major contributor to hand surface infection barrier and its association with morbidity to infectious disease

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