Raman Spectroscopy to Characterize Bladder Tissue for Multidimensional Diagnostics of Cancer in Urology

Fiber optic Raman spectroscopy offers labelfree identification of cancer in the bladder under in vivo conditions. However, state-of-the-art Raman technology does not enable to scan the entire bladder wall. Our multidimensional approach within the project Uro-MDD combines panoramic 3D-image reconstru...

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Autores principales:	Krafft C., Guo S., Bocklitz T., Popp J., Bronsert P., Miernik A.
Formato:	article
Lenguaje:	EN
Publicado:	De Gruyter 2020
Materias:	raman spectroscopy raman imaging endoscopy cancer diagnosis chemometric data analysis Medicine R
Acceso en línea:	https://doaj.org/article/2d8329e5f04c435da8e2e652e9e57b45
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spelling	oai:doaj.org-article:2d8329e5f04c435da8e2e652e9e57b452021-12-05T14:10:42ZRaman Spectroscopy to Characterize Bladder Tissue for Multidimensional Diagnostics of Cancer in Urology2364-550410.1515/cdbme-2020-3063https://doaj.org/article/2d8329e5f04c435da8e2e652e9e57b452020-09-01T00:00:00Zhttps://doi.org/10.1515/cdbme-2020-3063https://doaj.org/toc/2364-5504Fiber optic Raman spectroscopy offers labelfree identification of cancer in the bladder under in vivo conditions. However, state-of-the-art Raman technology does not enable to scan the entire bladder wall. Our multidimensional approach within the project Uro-MDD combines panoramic 3D-image reconstruction of white light cystoscopy and fluorescence lifetime imaging to define regions of interest for Raman-assisted diagnostics. First Raman results are presented from human control and cancer bladder specimens that demonstrated how to obtain specific molecular information. Such Raman images can be used in a clinical setting to determine cancer margins and the resection status. Fiber probes are under development to translate the technique to in vivo screening.Krafft C.Guo S.Bocklitz T.Popp J.Bronsert P.Miernik A.De Gruyterarticleraman spectroscopyraman imagingendoscopycancer diagnosischemometric data analysisMedicineRENCurrent Directions in Biomedical Engineering, Vol 6, Iss 3, Pp 250-253 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	raman spectroscopy raman imaging endoscopy cancer diagnosis chemometric data analysis Medicine R
spellingShingle	raman spectroscopy raman imaging endoscopy cancer diagnosis chemometric data analysis Medicine R Krafft C. Guo S. Bocklitz T. Popp J. Bronsert P. Miernik A. Raman Spectroscopy to Characterize Bladder Tissue for Multidimensional Diagnostics of Cancer in Urology
description	Fiber optic Raman spectroscopy offers labelfree identification of cancer in the bladder under in vivo conditions. However, state-of-the-art Raman technology does not enable to scan the entire bladder wall. Our multidimensional approach within the project Uro-MDD combines panoramic 3D-image reconstruction of white light cystoscopy and fluorescence lifetime imaging to define regions of interest for Raman-assisted diagnostics. First Raman results are presented from human control and cancer bladder specimens that demonstrated how to obtain specific molecular information. Such Raman images can be used in a clinical setting to determine cancer margins and the resection status. Fiber probes are under development to translate the technique to in vivo screening.
format	article
author	Krafft C. Guo S. Bocklitz T. Popp J. Bronsert P. Miernik A.
author_facet	Krafft C. Guo S. Bocklitz T. Popp J. Bronsert P. Miernik A.
author_sort	Krafft C.
title	Raman Spectroscopy to Characterize Bladder Tissue for Multidimensional Diagnostics of Cancer in Urology
title_short	Raman Spectroscopy to Characterize Bladder Tissue for Multidimensional Diagnostics of Cancer in Urology
title_full	Raman Spectroscopy to Characterize Bladder Tissue for Multidimensional Diagnostics of Cancer in Urology
title_fullStr	Raman Spectroscopy to Characterize Bladder Tissue for Multidimensional Diagnostics of Cancer in Urology
title_full_unstemmed	Raman Spectroscopy to Characterize Bladder Tissue for Multidimensional Diagnostics of Cancer in Urology
title_sort	raman spectroscopy to characterize bladder tissue for multidimensional diagnostics of cancer in urology
publisher	De Gruyter
publishDate	2020
url	https://doaj.org/article/2d8329e5f04c435da8e2e652e9e57b45
work_keys_str_mv	AT krafftc ramanspectroscopytocharacterizebladdertissueformultidimensionaldiagnosticsofcancerinurology AT guos ramanspectroscopytocharacterizebladdertissueformultidimensionaldiagnosticsofcancerinurology AT bocklitzt ramanspectroscopytocharacterizebladdertissueformultidimensionaldiagnosticsofcancerinurology AT poppj ramanspectroscopytocharacterizebladdertissueformultidimensionaldiagnosticsofcancerinurology AT bronsertp ramanspectroscopytocharacterizebladdertissueformultidimensionaldiagnosticsofcancerinurology AT miernika ramanspectroscopytocharacterizebladdertissueformultidimensionaldiagnosticsofcancerinurology
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Raman Spectroscopy to Characterize Bladder Tissue for Multidimensional Diagnostics of Cancer in Urology

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