Versatile functional roles of horizontal cells in the retinal circuit

Abstract In the retinal circuit, environmental light signals are converted into electrical signals that can be decoded properly by the brain. At the first synapse of the visual system, information flow from photoreceptors to bipolar cells is modulated by horizontal cells (HCs), however, their functi...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Taro Chaya, Akihiro Matsumoto, Yuko Sugita, Satoshi Watanabe, Ryusuke Kuwahara, Masao Tachibana, Takahisa Furukawa
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2d8538dcb7834fdaa45358c1dcf59fe0
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:2d8538dcb7834fdaa45358c1dcf59fe0
record_format	dspace
spelling	oai:doaj.org-article:2d8538dcb7834fdaa45358c1dcf59fe02021-12-02T16:08:20ZVersatile functional roles of horizontal cells in the retinal circuit10.1038/s41598-017-05543-22045-2322https://doaj.org/article/2d8538dcb7834fdaa45358c1dcf59fe02017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-05543-2https://doaj.org/toc/2045-2322Abstract In the retinal circuit, environmental light signals are converted into electrical signals that can be decoded properly by the brain. At the first synapse of the visual system, information flow from photoreceptors to bipolar cells is modulated by horizontal cells (HCs), however, their functional contribution to retinal output and individual visual function is not fully understood. In the current study, we investigated functional roles for HCs in retinal ganglion cell (RGC) response properties and optokinetic responses by establishing a HC-depleted mouse line. We observed that HC depletion impairs the antagonistic center-surround receptive field formation of RGCs, supporting a previously reported HC function revealed by pharmacological approaches. In addition, we found that HC loss reduces both the ON and OFF response diversities of RGCs, impairs adjustment of the sensitivity to ambient light at the retinal output level, and alters spatial frequency tuning at an individual level. Taken together, our current study suggests multiple functional aspects of HCs crucial for visual processing.Taro ChayaAkihiro MatsumotoYuko SugitaSatoshi WatanabeRyusuke KuwaharaMasao TachibanaTakahisa FurukawaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Taro Chaya Akihiro Matsumoto Yuko Sugita Satoshi Watanabe Ryusuke Kuwahara Masao Tachibana Takahisa Furukawa Versatile functional roles of horizontal cells in the retinal circuit
description	Abstract In the retinal circuit, environmental light signals are converted into electrical signals that can be decoded properly by the brain. At the first synapse of the visual system, information flow from photoreceptors to bipolar cells is modulated by horizontal cells (HCs), however, their functional contribution to retinal output and individual visual function is not fully understood. In the current study, we investigated functional roles for HCs in retinal ganglion cell (RGC) response properties and optokinetic responses by establishing a HC-depleted mouse line. We observed that HC depletion impairs the antagonistic center-surround receptive field formation of RGCs, supporting a previously reported HC function revealed by pharmacological approaches. In addition, we found that HC loss reduces both the ON and OFF response diversities of RGCs, impairs adjustment of the sensitivity to ambient light at the retinal output level, and alters spatial frequency tuning at an individual level. Taken together, our current study suggests multiple functional aspects of HCs crucial for visual processing.
format	article
author	Taro Chaya Akihiro Matsumoto Yuko Sugita Satoshi Watanabe Ryusuke Kuwahara Masao Tachibana Takahisa Furukawa
author_facet	Taro Chaya Akihiro Matsumoto Yuko Sugita Satoshi Watanabe Ryusuke Kuwahara Masao Tachibana Takahisa Furukawa
author_sort	Taro Chaya
title	Versatile functional roles of horizontal cells in the retinal circuit
title_short	Versatile functional roles of horizontal cells in the retinal circuit
title_full	Versatile functional roles of horizontal cells in the retinal circuit
title_fullStr	Versatile functional roles of horizontal cells in the retinal circuit
title_full_unstemmed	Versatile functional roles of horizontal cells in the retinal circuit
title_sort	versatile functional roles of horizontal cells in the retinal circuit
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/2d8538dcb7834fdaa45358c1dcf59fe0
work_keys_str_mv	AT tarochaya versatilefunctionalrolesofhorizontalcellsintheretinalcircuit AT akihiromatsumoto versatilefunctionalrolesofhorizontalcellsintheretinalcircuit AT yukosugita versatilefunctionalrolesofhorizontalcellsintheretinalcircuit AT satoshiwatanabe versatilefunctionalrolesofhorizontalcellsintheretinalcircuit AT ryusukekuwahara versatilefunctionalrolesofhorizontalcellsintheretinalcircuit AT masaotachibana versatilefunctionalrolesofhorizontalcellsintheretinalcircuit AT takahisafurukawa versatilefunctionalrolesofhorizontalcellsintheretinalcircuit
_version_	1718384519327776768

Versatile functional roles of horizontal cells in the retinal circuit

Ejemplares similares