Pityriasis rubra pilaris-like eruption following insulin therapy initiation

Pityriasis rubra pilaris (PRP) is a chronic disorder of keratinization of unclear pathogenesis. PRP-like eruptions induced by drugs have rarely been described. A previously healthy 29-year-old man presented with a generalized, rapidly spreading, erythematosquamous dermatosis, that started three day...

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Autores principales:	Talel Badri, Anissa Zaouak, Ghozlane Lakhoua, Wafaa Koubaa, Sami Fennich, Ahmed Zaiem
Formato:	article
Lenguaje:	EN
Publicado:	Mattioli1885 2016
Materias:	pityriasis rubra pilaris insulin drug-induced cutaneous rash skin Dermatology RL1-803
Acceso en línea:	https://doaj.org/article/2d8ed550d9fb490386f27f7353b3eb4a
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spelling	oai:doaj.org-article:2d8ed550d9fb490386f27f7353b3eb4a2021-11-17T08:31:01ZPityriasis rubra pilaris-like eruption following insulin therapy initiation10.5826/dpc.0604a042160-9381https://doaj.org/article/2d8ed550d9fb490386f27f7353b3eb4a2016-10-01T00:00:00Zhttp://dpcj.org/index.php/dpc/article/view/160https://doaj.org/toc/2160-9381 Pityriasis rubra pilaris (PRP) is a chronic disorder of keratinization of unclear pathogenesis. PRP-like eruptions induced by drugs have rarely been described. A previously healthy 29-year-old man presented with a generalized, rapidly spreading, erythematosquamous dermatosis, that started three days after initiation of subcutaneous insulin therapy for diabetes mellitus type 1. Clinical and histopathological features were consistent with a PRP-like eruption, possibly due to insulin therapy. The patient was switched to insulin analogue therapy and a complete healing of all lesions was achieved after two months. No recurrence was seen after one year of follow-up. Other possible etiologies of PRP were excluded. The mechanism leading to the occurrence of drug-induced PRP-like eruptions are not clear. Since PRP may occur in the context of immunological anomalies, it is possible that diabetes mellitus type 1 may have been a predisposing condition for the development of PRP in this case. Talel BadriAnissa ZaouakGhozlane LakhouaWafaa KoubaaSami FennichAhmed ZaiemMattioli1885articlepityriasis rubra pilarisinsulindrug-inducedcutaneous rashskinDermatologyRL1-803ENDermatology Practical & Conceptual (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	pityriasis rubra pilaris insulin drug-induced cutaneous rash skin Dermatology RL1-803
spellingShingle	pityriasis rubra pilaris insulin drug-induced cutaneous rash skin Dermatology RL1-803 Talel Badri Anissa Zaouak Ghozlane Lakhoua Wafaa Koubaa Sami Fennich Ahmed Zaiem Pityriasis rubra pilaris-like eruption following insulin therapy initiation
description	Pityriasis rubra pilaris (PRP) is a chronic disorder of keratinization of unclear pathogenesis. PRP-like eruptions induced by drugs have rarely been described. A previously healthy 29-year-old man presented with a generalized, rapidly spreading, erythematosquamous dermatosis, that started three days after initiation of subcutaneous insulin therapy for diabetes mellitus type 1. Clinical and histopathological features were consistent with a PRP-like eruption, possibly due to insulin therapy. The patient was switched to insulin analogue therapy and a complete healing of all lesions was achieved after two months. No recurrence was seen after one year of follow-up. Other possible etiologies of PRP were excluded. The mechanism leading to the occurrence of drug-induced PRP-like eruptions are not clear. Since PRP may occur in the context of immunological anomalies, it is possible that diabetes mellitus type 1 may have been a predisposing condition for the development of PRP in this case.
format	article
author	Talel Badri Anissa Zaouak Ghozlane Lakhoua Wafaa Koubaa Sami Fennich Ahmed Zaiem
author_facet	Talel Badri Anissa Zaouak Ghozlane Lakhoua Wafaa Koubaa Sami Fennich Ahmed Zaiem
author_sort	Talel Badri
title	Pityriasis rubra pilaris-like eruption following insulin therapy initiation
title_short	Pityriasis rubra pilaris-like eruption following insulin therapy initiation
title_full	Pityriasis rubra pilaris-like eruption following insulin therapy initiation
title_fullStr	Pityriasis rubra pilaris-like eruption following insulin therapy initiation
title_full_unstemmed	Pityriasis rubra pilaris-like eruption following insulin therapy initiation
title_sort	pityriasis rubra pilaris-like eruption following insulin therapy initiation
publisher	Mattioli1885
publishDate	2016
url	https://doaj.org/article/2d8ed550d9fb490386f27f7353b3eb4a
work_keys_str_mv	AT talelbadri pityriasisrubrapilarislikeeruptionfollowinginsulintherapyinitiation AT anissazaouak pityriasisrubrapilarislikeeruptionfollowinginsulintherapyinitiation AT ghozlanelakhoua pityriasisrubrapilarislikeeruptionfollowinginsulintherapyinitiation AT wafaakoubaa pityriasisrubrapilarislikeeruptionfollowinginsulintherapyinitiation AT samifennich pityriasisrubrapilarislikeeruptionfollowinginsulintherapyinitiation AT ahmedzaiem pityriasisrubrapilarislikeeruptionfollowinginsulintherapyinitiation
_version_	1718425725549150208

Pityriasis rubra pilaris-like eruption following insulin therapy initiation

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