Cellular stress alters 3′UTR landscape through alternative polyadenylation and isoform-specific degradation

The function and consequences of alternative polyadenylation (APA) in stressed cells are largely unclear. Here, the authors show that stress-induced mRNA degradation depends on 3′UTR length and that APA-mediated 3′UTR shortening is an adaptive stress response mechanism for selective transcript stabi...

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Autores principales:	Dinghai Zheng, Ruijia Wang, Qingbao Ding, Tianying Wang, Bingning Xie, Lu Wei, Zhaohua Zhong, Bin Tian
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2d8fedf2c109461cb0a2b230cda92eaa
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spelling	oai:doaj.org-article:2d8fedf2c109461cb0a2b230cda92eaa2021-12-02T17:31:15ZCellular stress alters 3′UTR landscape through alternative polyadenylation and isoform-specific degradation10.1038/s41467-018-04730-72041-1723https://doaj.org/article/2d8fedf2c109461cb0a2b230cda92eaa2018-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04730-7https://doaj.org/toc/2041-1723The function and consequences of alternative polyadenylation (APA) in stressed cells are largely unclear. Here, the authors show that stress-induced mRNA degradation depends on 3′UTR length and that APA-mediated 3′UTR shortening is an adaptive stress response mechanism for selective transcript stabilization.Dinghai ZhengRuijia WangQingbao DingTianying WangBingning XieLu WeiZhaohua ZhongBin TianNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Dinghai Zheng Ruijia Wang Qingbao Ding Tianying Wang Bingning Xie Lu Wei Zhaohua Zhong Bin Tian Cellular stress alters 3′UTR landscape through alternative polyadenylation and isoform-specific degradation
description	The function and consequences of alternative polyadenylation (APA) in stressed cells are largely unclear. Here, the authors show that stress-induced mRNA degradation depends on 3′UTR length and that APA-mediated 3′UTR shortening is an adaptive stress response mechanism for selective transcript stabilization.
format	article
author	Dinghai Zheng Ruijia Wang Qingbao Ding Tianying Wang Bingning Xie Lu Wei Zhaohua Zhong Bin Tian
author_facet	Dinghai Zheng Ruijia Wang Qingbao Ding Tianying Wang Bingning Xie Lu Wei Zhaohua Zhong Bin Tian
author_sort	Dinghai Zheng
title	Cellular stress alters 3′UTR landscape through alternative polyadenylation and isoform-specific degradation
title_short	Cellular stress alters 3′UTR landscape through alternative polyadenylation and isoform-specific degradation
title_full	Cellular stress alters 3′UTR landscape through alternative polyadenylation and isoform-specific degradation
title_fullStr	Cellular stress alters 3′UTR landscape through alternative polyadenylation and isoform-specific degradation
title_full_unstemmed	Cellular stress alters 3′UTR landscape through alternative polyadenylation and isoform-specific degradation
title_sort	cellular stress alters 3′utr landscape through alternative polyadenylation and isoform-specific degradation
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/2d8fedf2c109461cb0a2b230cda92eaa
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Cellular stress alters 3′UTR landscape through alternative polyadenylation and isoform-specific degradation

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