Cellular stress alters 3′UTR landscape through alternative polyadenylation and isoform-specific degradation

The function and consequences of alternative polyadenylation (APA) in stressed cells are largely unclear. Here, the authors show that stress-induced mRNA degradation depends on 3′UTR length and that APA-mediated 3′UTR shortening is an adaptive stress response mechanism for selective transcript stabi...

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Autores principales: Dinghai Zheng, Ruijia Wang, Qingbao Ding, Tianying Wang, Bingning Xie, Lu Wei, Zhaohua Zhong, Bin Tian
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/2d8fedf2c109461cb0a2b230cda92eaa
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