LncRNA ADAMTS9-AS2 is a Prognostic Biomarker and Correlated with Immune Infiltrates in Lung Adenocarcinoma

Zhichao Lin,1,&ast; Wenhai Huang,1,&ast; Yongsheng Yi,1,&ast; Dongbing Li,2,&ast; Zehua Xie,1 Zumei Li,1 Min Ye1 1Department of Thoracic Surgery, Jiangmen Central Hospital, Affiliated Jiangmen Hospital of Sun Yat-sen University, Jiangmen, 529030, Guangdong, People’s Republic of China...

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Autores principales:	Lin Z, Huang W, Yi Y, Li D, Xie Z, Li Z, Ye M
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	lung adenocarcinoma adamts9-as2 antisense rna 2 prognosis immune infiltration biomarker Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/2d9267374b7648caa48d470c1e07fdfd
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spelling	oai:doaj.org-article:2d9267374b7648caa48d470c1e07fdfd2021-11-21T19:08:51ZLncRNA ADAMTS9-AS2 is a Prognostic Biomarker and Correlated with Immune Infiltrates in Lung Adenocarcinoma1178-7074https://doaj.org/article/2d9267374b7648caa48d470c1e07fdfd2021-11-01T00:00:00Zhttps://www.dovepress.com/lncrna-adamts9-as2-is-a-prognostic-biomarker-and-correlated-with-immun-peer-reviewed-fulltext-article-IJGMhttps://doaj.org/toc/1178-7074Zhichao Lin,1,&ast; Wenhai Huang,1,&ast; Yongsheng Yi,1,&ast; Dongbing Li,2,&ast; Zehua Xie,1 Zumei Li,1 Min Ye1 1Department of Thoracic Surgery, Jiangmen Central Hospital, Affiliated Jiangmen Hospital of Sun Yat-sen University, Jiangmen, 529030, Guangdong, People’s Republic of China; 2MyGene Diagnostics Co., Ltd., Guangzhou, 510000, Guangdong, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Zhichao Lin; Min YeDepartment of Thoracic Surgery, Jiangmen Central Hospital, Affiliated Jiangmen Hospital of Sun Yat-sen University, No. 23 Haibang Street, Beijie, Jiangmen, 529030, Guangdong, People’s Republic of ChinaTel +86-750-3989432Email 230160549@qq.com; Yeminzhangcuiyuan@126.comBackground: The role of long noncoding RNA (LncRNA) ADAMTS9 antisense RNA 2 (ADAMTS9-AS2) is unclear in lung adenocarcinoma (LUAD). The aim of this study was to explore the relationship between ADAMTS9-AS2 and LUAD, based on The Cancer Genome Atlas (TCGA) database and bioinformatics analysis.Methods: Various statistical methods, Kaplan–Meier method, Cox regression analysis, GSEA, and immune infiltration analysis were used to evaluate the relationship between clinical features and ADAMTS9-AS2 expression, prognostic factors, and the significant involvement of ADAMTS9-AS2 in function.Results: In LUAD patients, low expression of ADAMTS9-AS2 was associated with N stage (P=0.011), gender (P=0.002), number of packs smoked (P=0.024) and smoker (P< 0.001). Low ADAMTS9-AS2 expression predicted a poorer overall survival (OS) (HR: 0.68; 95% CI: 0.51– 0.91; P=0.01). And ADAMTS9-AS2 expression (HR: 0.626; 95% CI: 0.397– 0.986; P=0.043) was independently correlated with OS in LUAD patients. Unwinding of DNA, extrinsic pathway, polo-like kinase-mediated events, cori cycle, MCM pathway, proteasome pathway, lagging strand synthesis and PCNA-dependent long patch base excision repair were differentially enriched in ADAMTS9-AS2 high expression phenotype. ADAMTS9-AS2 expression was correlated with certain immune infiltrating cells.Conclusion: In LUAD patients, ADAMTS9-AS2 expression was significantly associated with poor survival and immune infiltration. ADAMTS9-AS2 may be a promising biomarker of prognosis and response to immunotherapy for LUAD.Keywords: lung adenocarcinoma, ADAMTS9-AS2 antisense RNA 2, prognosis, immune infiltration, biomarkerLin ZHuang WYi YLi DXie ZLi ZYe MDove Medical Pressarticlelung adenocarcinomaadamts9-as2 antisense rna 2prognosisimmune infiltrationbiomarkerMedicine (General)R5-920ENInternational Journal of General Medicine, Vol Volume 14, Pp 8541-8555 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	lung adenocarcinoma adamts9-as2 antisense rna 2 prognosis immune infiltration biomarker Medicine (General) R5-920
spellingShingle	lung adenocarcinoma adamts9-as2 antisense rna 2 prognosis immune infiltration biomarker Medicine (General) R5-920 Lin Z Huang W Yi Y Li D Xie Z Li Z Ye M LncRNA ADAMTS9-AS2 is a Prognostic Biomarker and Correlated with Immune Infiltrates in Lung Adenocarcinoma
description	Zhichao Lin,1,&ast; Wenhai Huang,1,&ast; Yongsheng Yi,1,&ast; Dongbing Li,2,&ast; Zehua Xie,1 Zumei Li,1 Min Ye1 1Department of Thoracic Surgery, Jiangmen Central Hospital, Affiliated Jiangmen Hospital of Sun Yat-sen University, Jiangmen, 529030, Guangdong, People’s Republic of China; 2MyGene Diagnostics Co., Ltd., Guangzhou, 510000, Guangdong, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Zhichao Lin; Min YeDepartment of Thoracic Surgery, Jiangmen Central Hospital, Affiliated Jiangmen Hospital of Sun Yat-sen University, No. 23 Haibang Street, Beijie, Jiangmen, 529030, Guangdong, People’s Republic of ChinaTel +86-750-3989432Email 230160549@qq.com; Yeminzhangcuiyuan@126.comBackground: The role of long noncoding RNA (LncRNA) ADAMTS9 antisense RNA 2 (ADAMTS9-AS2) is unclear in lung adenocarcinoma (LUAD). The aim of this study was to explore the relationship between ADAMTS9-AS2 and LUAD, based on The Cancer Genome Atlas (TCGA) database and bioinformatics analysis.Methods: Various statistical methods, Kaplan–Meier method, Cox regression analysis, GSEA, and immune infiltration analysis were used to evaluate the relationship between clinical features and ADAMTS9-AS2 expression, prognostic factors, and the significant involvement of ADAMTS9-AS2 in function.Results: In LUAD patients, low expression of ADAMTS9-AS2 was associated with N stage (P=0.011), gender (P=0.002), number of packs smoked (P=0.024) and smoker (P< 0.001). Low ADAMTS9-AS2 expression predicted a poorer overall survival (OS) (HR: 0.68; 95% CI: 0.51– 0.91; P=0.01). And ADAMTS9-AS2 expression (HR: 0.626; 95% CI: 0.397– 0.986; P=0.043) was independently correlated with OS in LUAD patients. Unwinding of DNA, extrinsic pathway, polo-like kinase-mediated events, cori cycle, MCM pathway, proteasome pathway, lagging strand synthesis and PCNA-dependent long patch base excision repair were differentially enriched in ADAMTS9-AS2 high expression phenotype. ADAMTS9-AS2 expression was correlated with certain immune infiltrating cells.Conclusion: In LUAD patients, ADAMTS9-AS2 expression was significantly associated with poor survival and immune infiltration. ADAMTS9-AS2 may be a promising biomarker of prognosis and response to immunotherapy for LUAD.Keywords: lung adenocarcinoma, ADAMTS9-AS2 antisense RNA 2, prognosis, immune infiltration, biomarker
format	article
author	Lin Z Huang W Yi Y Li D Xie Z Li Z Ye M
author_facet	Lin Z Huang W Yi Y Li D Xie Z Li Z Ye M
author_sort	Lin Z
title	LncRNA ADAMTS9-AS2 is a Prognostic Biomarker and Correlated with Immune Infiltrates in Lung Adenocarcinoma
title_short	LncRNA ADAMTS9-AS2 is a Prognostic Biomarker and Correlated with Immune Infiltrates in Lung Adenocarcinoma
title_full	LncRNA ADAMTS9-AS2 is a Prognostic Biomarker and Correlated with Immune Infiltrates in Lung Adenocarcinoma
title_fullStr	LncRNA ADAMTS9-AS2 is a Prognostic Biomarker and Correlated with Immune Infiltrates in Lung Adenocarcinoma
title_full_unstemmed	LncRNA ADAMTS9-AS2 is a Prognostic Biomarker and Correlated with Immune Infiltrates in Lung Adenocarcinoma
title_sort	lncrna adamts9-as2 is a prognostic biomarker and correlated with immune infiltrates in lung adenocarcinoma
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/2d9267374b7648caa48d470c1e07fdfd
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LncRNA ADAMTS9-AS2 is a Prognostic Biomarker and Correlated with Immune Infiltrates in Lung Adenocarcinoma

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