The role of COVID‐19 survivor status and gender towards neutralizing antibody titers 1, 2, 3 months after Sinovac vaccine administration on clinical‐year medical students in Indonesia

Background: Sinovac was the first vaccine used in Indonesia against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, data regarding the effects of certain variables such as clinical demographics on antibody levels in individuals vaccinated with Sinovac are scarce. This study ai...

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Autores principales:	Rivaldo Steven Heriyanto, Andree Kurniawan, Felix Wijovi, Devina Adella Halim, Claudia Jodhinata, Elizabeth Marcella, Billy Susanto, Johan Wibowo, Michele Indrawan, Nadia Khoirunnisa Heryadi, Michelle Imanuelly, Jonathan Juniard Anurantha, Timotius Ivan Hariyanto, Chintya Marcellin, Terry Devita Sinaga, Saraswati Anindita Rizki, Novia Sieto, Jeremia Immanuel Siregar, Nata Pratama Hardjo Lugito
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	COVID-19 antibody titers Sinovac vaccine COVID-19 vaccine Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/2d956e8e294e4a3280b6e0917a7395ac
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spelling	oai:doaj.org-article:2d956e8e294e4a3280b6e0917a7395ac2021-11-16T04:09:12ZThe role of COVID‐19 survivor status and gender towards neutralizing antibody titers 1, 2, 3 months after Sinovac vaccine administration on clinical‐year medical students in Indonesia1201-971210.1016/j.ijid.2021.10.009https://doaj.org/article/2d956e8e294e4a3280b6e0917a7395ac2021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1201971221007979https://doaj.org/toc/1201-9712Background: Sinovac was the first vaccine used in Indonesia against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, data regarding the effects of certain variables such as clinical demographics on antibody levels in individuals vaccinated with Sinovac are scarce. This study aimed to investigate the impact of gender and previous SARS-CoV-2 infection status on neutralizing antibody titers 1, 2, and 3 months after administration of the Sinovac vaccine.Method: A cross-sectional study was conducted from February to May 2021. Data on neutralizing antibody levels, previous SARS-CoV-2 infection status, and gender were retrieved from the monthly quantitative serology evaluation database of Siloam Hospitals Lippo Village, Tangerang, Indonesia. The role of each variable was analyzed using the t-test or Mann-Whitney U test, depending on data distribution.Result: Data from 350 participants were collected for the study. Participants with a history of a positive SARS-CoV-2 RT-PCR test had significantly higher neutralizing antibody titers in the first (144 U/mL, p = 0.036) and second months (144 U/mL, p = 0.005) after vaccination compared with those without a history of positive RT-PCR test. Female participants also had significantly higher neutralizing antibody titers in the first, second, and third months (43 U/mL, 42 U/mL, and 39 U/mL, respectively; p = 0.001, p = 0.002, and p = 0.003, respectively) after vaccination compared to males.Conclusion: COVID-19 survivor status and the female gender were associated with higher neutralizing antibody titers after Sinovac vaccine administration.Rivaldo Steven HeriyantoAndree KurniawanFelix WijoviDevina Adella HalimClaudia JodhinataElizabeth MarcellaBilly SusantoJohan WibowoMichele IndrawanNadia Khoirunnisa HeryadiMichelle ImanuellyJonathan Juniard AnuranthaTimotius Ivan HariyantoChintya MarcellinTerry Devita SinagaSaraswati Anindita RizkiNovia SietoJeremia Immanuel SiregarNata Pratama Hardjo LugitoElsevierarticleCOVID-19antibody titersSinovac vaccineCOVID-19 vaccineInfectious and parasitic diseasesRC109-216ENInternational Journal of Infectious Diseases, Vol 113, Iss , Pp 336-338 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	COVID-19 antibody titers Sinovac vaccine COVID-19 vaccine Infectious and parasitic diseases RC109-216
spellingShingle	COVID-19 antibody titers Sinovac vaccine COVID-19 vaccine Infectious and parasitic diseases RC109-216 Rivaldo Steven Heriyanto Andree Kurniawan Felix Wijovi Devina Adella Halim Claudia Jodhinata Elizabeth Marcella Billy Susanto Johan Wibowo Michele Indrawan Nadia Khoirunnisa Heryadi Michelle Imanuelly Jonathan Juniard Anurantha Timotius Ivan Hariyanto Chintya Marcellin Terry Devita Sinaga Saraswati Anindita Rizki Novia Sieto Jeremia Immanuel Siregar Nata Pratama Hardjo Lugito The role of COVID‐19 survivor status and gender towards neutralizing antibody titers 1, 2, 3 months after Sinovac vaccine administration on clinical‐year medical students in Indonesia
description	Background: Sinovac was the first vaccine used in Indonesia against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, data regarding the effects of certain variables such as clinical demographics on antibody levels in individuals vaccinated with Sinovac are scarce. This study aimed to investigate the impact of gender and previous SARS-CoV-2 infection status on neutralizing antibody titers 1, 2, and 3 months after administration of the Sinovac vaccine.Method: A cross-sectional study was conducted from February to May 2021. Data on neutralizing antibody levels, previous SARS-CoV-2 infection status, and gender were retrieved from the monthly quantitative serology evaluation database of Siloam Hospitals Lippo Village, Tangerang, Indonesia. The role of each variable was analyzed using the t-test or Mann-Whitney U test, depending on data distribution.Result: Data from 350 participants were collected for the study. Participants with a history of a positive SARS-CoV-2 RT-PCR test had significantly higher neutralizing antibody titers in the first (144 U/mL, p = 0.036) and second months (144 U/mL, p = 0.005) after vaccination compared with those without a history of positive RT-PCR test. Female participants also had significantly higher neutralizing antibody titers in the first, second, and third months (43 U/mL, 42 U/mL, and 39 U/mL, respectively; p = 0.001, p = 0.002, and p = 0.003, respectively) after vaccination compared to males.Conclusion: COVID-19 survivor status and the female gender were associated with higher neutralizing antibody titers after Sinovac vaccine administration.
format	article
author	Rivaldo Steven Heriyanto Andree Kurniawan Felix Wijovi Devina Adella Halim Claudia Jodhinata Elizabeth Marcella Billy Susanto Johan Wibowo Michele Indrawan Nadia Khoirunnisa Heryadi Michelle Imanuelly Jonathan Juniard Anurantha Timotius Ivan Hariyanto Chintya Marcellin Terry Devita Sinaga Saraswati Anindita Rizki Novia Sieto Jeremia Immanuel Siregar Nata Pratama Hardjo Lugito
author_facet	Rivaldo Steven Heriyanto Andree Kurniawan Felix Wijovi Devina Adella Halim Claudia Jodhinata Elizabeth Marcella Billy Susanto Johan Wibowo Michele Indrawan Nadia Khoirunnisa Heryadi Michelle Imanuelly Jonathan Juniard Anurantha Timotius Ivan Hariyanto Chintya Marcellin Terry Devita Sinaga Saraswati Anindita Rizki Novia Sieto Jeremia Immanuel Siregar Nata Pratama Hardjo Lugito
author_sort	Rivaldo Steven Heriyanto
title	The role of COVID‐19 survivor status and gender towards neutralizing antibody titers 1, 2, 3 months after Sinovac vaccine administration on clinical‐year medical students in Indonesia
title_short	The role of COVID‐19 survivor status and gender towards neutralizing antibody titers 1, 2, 3 months after Sinovac vaccine administration on clinical‐year medical students in Indonesia
title_full	The role of COVID‐19 survivor status and gender towards neutralizing antibody titers 1, 2, 3 months after Sinovac vaccine administration on clinical‐year medical students in Indonesia
title_fullStr	The role of COVID‐19 survivor status and gender towards neutralizing antibody titers 1, 2, 3 months after Sinovac vaccine administration on clinical‐year medical students in Indonesia
title_full_unstemmed	The role of COVID‐19 survivor status and gender towards neutralizing antibody titers 1, 2, 3 months after Sinovac vaccine administration on clinical‐year medical students in Indonesia
title_sort	role of covid‐19 survivor status and gender towards neutralizing antibody titers 1, 2, 3 months after sinovac vaccine administration on clinical‐year medical students in indonesia
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/2d956e8e294e4a3280b6e0917a7395ac
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The role of COVID‐19 survivor status and gender towards neutralizing antibody titers 1, 2, 3 months after Sinovac vaccine administration on clinical‐year medical students in Indonesia

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