Proximal and distal spinal neurons innervating multiple synergist and antagonist motor pools

Motoneurons (MNs) control muscle contractions, and their recruitment by premotor circuits is tuned to produce accurate motor behaviours. To understand how these circuits coordinate movement across and between joints, it is necessary to understand whether spinal neurons pre-synaptic to motor pools ha...

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Autores principales:	Remi Ronzano, Camille Lancelin, Gardave Singh Bhumbra, Robert M Brownstone, Marco Beato
Formato:	article
Lenguaje:	EN
Publicado:	eLife Sciences Publications Ltd 2021
Materias:	spinal cord trans-synaptic tracing rabies premotor interneurons motoneurons Medicine R Science Q Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/2d96da9a2b0d497697fc932dc7272900
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spelling	oai:doaj.org-article:2d96da9a2b0d497697fc932dc72729002021-11-30T15:12:21ZProximal and distal spinal neurons innervating multiple synergist and antagonist motor pools10.7554/eLife.708582050-084Xe70858https://doaj.org/article/2d96da9a2b0d497697fc932dc72729002021-11-01T00:00:00Zhttps://elifesciences.org/articles/70858https://doaj.org/toc/2050-084XMotoneurons (MNs) control muscle contractions, and their recruitment by premotor circuits is tuned to produce accurate motor behaviours. To understand how these circuits coordinate movement across and between joints, it is necessary to understand whether spinal neurons pre-synaptic to motor pools have divergent projections to more than one MN population. Here, we used modified rabies virus tracing in mice to investigate premotor interneurons projecting to synergist flexor or extensor MNs, as well as those projecting to antagonist pairs of muscles controlling the ankle joint. We show that similar proportions of premotor neurons diverge to synergist and antagonist motor pools. Divergent premotor neurons were seen throughout the spinal cord, with decreasing numbers but increasing proportion with distance from the hindlimb enlargement. In the cervical cord, divergent long descending propriospinal neurons were found in contralateral lamina VIII, had large somata, were neither glycinergic, nor cholinergic, and projected to both lumbar and cervical MNs. We conclude that distributed spinal premotor neurons coordinate activity across multiple motor pools and that there are spinal neurons mediating co-contraction of antagonist muscles.Remi RonzanoCamille LancelinGardave Singh BhumbraRobert M BrownstoneMarco BeatoeLife Sciences Publications Ltdarticlespinal cordtrans-synaptic tracingrabiespremotor interneuronsmotoneuronsMedicineRScienceQBiology (General)QH301-705.5ENeLife, Vol 10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	spinal cord trans-synaptic tracing rabies premotor interneurons motoneurons Medicine R Science Q Biology (General) QH301-705.5
spellingShingle	spinal cord trans-synaptic tracing rabies premotor interneurons motoneurons Medicine R Science Q Biology (General) QH301-705.5 Remi Ronzano Camille Lancelin Gardave Singh Bhumbra Robert M Brownstone Marco Beato Proximal and distal spinal neurons innervating multiple synergist and antagonist motor pools
description	Motoneurons (MNs) control muscle contractions, and their recruitment by premotor circuits is tuned to produce accurate motor behaviours. To understand how these circuits coordinate movement across and between joints, it is necessary to understand whether spinal neurons pre-synaptic to motor pools have divergent projections to more than one MN population. Here, we used modified rabies virus tracing in mice to investigate premotor interneurons projecting to synergist flexor or extensor MNs, as well as those projecting to antagonist pairs of muscles controlling the ankle joint. We show that similar proportions of premotor neurons diverge to synergist and antagonist motor pools. Divergent premotor neurons were seen throughout the spinal cord, with decreasing numbers but increasing proportion with distance from the hindlimb enlargement. In the cervical cord, divergent long descending propriospinal neurons were found in contralateral lamina VIII, had large somata, were neither glycinergic, nor cholinergic, and projected to both lumbar and cervical MNs. We conclude that distributed spinal premotor neurons coordinate activity across multiple motor pools and that there are spinal neurons mediating co-contraction of antagonist muscles.
format	article
author	Remi Ronzano Camille Lancelin Gardave Singh Bhumbra Robert M Brownstone Marco Beato
author_facet	Remi Ronzano Camille Lancelin Gardave Singh Bhumbra Robert M Brownstone Marco Beato
author_sort	Remi Ronzano
title	Proximal and distal spinal neurons innervating multiple synergist and antagonist motor pools
title_short	Proximal and distal spinal neurons innervating multiple synergist and antagonist motor pools
title_full	Proximal and distal spinal neurons innervating multiple synergist and antagonist motor pools
title_fullStr	Proximal and distal spinal neurons innervating multiple synergist and antagonist motor pools
title_full_unstemmed	Proximal and distal spinal neurons innervating multiple synergist and antagonist motor pools
title_sort	proximal and distal spinal neurons innervating multiple synergist and antagonist motor pools
publisher	eLife Sciences Publications Ltd
publishDate	2021
url	https://doaj.org/article/2d96da9a2b0d497697fc932dc7272900
work_keys_str_mv	AT remironzano proximalanddistalspinalneuronsinnervatingmultiplesynergistandantagonistmotorpools AT camillelancelin proximalanddistalspinalneuronsinnervatingmultiplesynergistandantagonistmotorpools AT gardavesinghbhumbra proximalanddistalspinalneuronsinnervatingmultiplesynergistandantagonistmotorpools AT robertmbrownstone proximalanddistalspinalneuronsinnervatingmultiplesynergistandantagonistmotorpools AT marcobeato proximalanddistalspinalneuronsinnervatingmultiplesynergistandantagonistmotorpools
_version_	1718406495727517696

Proximal and distal spinal neurons innervating multiple synergist and antagonist motor pools

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