Genetic lineage tracing defines myofibroblast origin and function in the injured heart

The origin and fate of myofibroblasts, the cells responsible for cardiac remodelling and fibrosis, is controversial. Here the authors show that cardiac myofibroblasts express periostin, derive exclusively from tissue-resident fibroblasts, are necessary for scar formation after injury, and can revert...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Onur Kanisicak, Hadi Khalil, Malina J. Ivey, Jason Karch, Bryan D. Maliken, Robert N. Correll, Matthew J. Brody, Suh-Chin J. Lin, Bruce J. Aronow, Michelle D. Tallquist, Jeffery D. Molkentin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2d97317374d240aba3646b2db0044a01
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:2d97317374d240aba3646b2db0044a01
record_format	dspace
spelling	oai:doaj.org-article:2d97317374d240aba3646b2db0044a012021-12-02T17:32:06ZGenetic lineage tracing defines myofibroblast origin and function in the injured heart10.1038/ncomms122602041-1723https://doaj.org/article/2d97317374d240aba3646b2db0044a012016-07-01T00:00:00Zhttps://doi.org/10.1038/ncomms12260https://doaj.org/toc/2041-1723The origin and fate of myofibroblasts, the cells responsible for cardiac remodelling and fibrosis, is controversial. Here the authors show that cardiac myofibroblasts express periostin, derive exclusively from tissue-resident fibroblasts, are necessary for scar formation after injury, and can revert back to a less-activated state upon injury resolution.Onur KanisicakHadi KhalilMalina J. IveyJason KarchBryan D. MalikenRobert N. CorrellMatthew J. BrodySuh-Chin J. LinBruce J. AronowMichelle D. TallquistJeffery D. MolkentinNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Onur Kanisicak Hadi Khalil Malina J. Ivey Jason Karch Bryan D. Maliken Robert N. Correll Matthew J. Brody Suh-Chin J. Lin Bruce J. Aronow Michelle D. Tallquist Jeffery D. Molkentin Genetic lineage tracing defines myofibroblast origin and function in the injured heart
description	The origin and fate of myofibroblasts, the cells responsible for cardiac remodelling and fibrosis, is controversial. Here the authors show that cardiac myofibroblasts express periostin, derive exclusively from tissue-resident fibroblasts, are necessary for scar formation after injury, and can revert back to a less-activated state upon injury resolution.
format	article
author	Onur Kanisicak Hadi Khalil Malina J. Ivey Jason Karch Bryan D. Maliken Robert N. Correll Matthew J. Brody Suh-Chin J. Lin Bruce J. Aronow Michelle D. Tallquist Jeffery D. Molkentin
author_facet	Onur Kanisicak Hadi Khalil Malina J. Ivey Jason Karch Bryan D. Maliken Robert N. Correll Matthew J. Brody Suh-Chin J. Lin Bruce J. Aronow Michelle D. Tallquist Jeffery D. Molkentin
author_sort	Onur Kanisicak
title	Genetic lineage tracing defines myofibroblast origin and function in the injured heart
title_short	Genetic lineage tracing defines myofibroblast origin and function in the injured heart
title_full	Genetic lineage tracing defines myofibroblast origin and function in the injured heart
title_fullStr	Genetic lineage tracing defines myofibroblast origin and function in the injured heart
title_full_unstemmed	Genetic lineage tracing defines myofibroblast origin and function in the injured heart
title_sort	genetic lineage tracing defines myofibroblast origin and function in the injured heart
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/2d97317374d240aba3646b2db0044a01
work_keys_str_mv	AT onurkanisicak geneticlineagetracingdefinesmyofibroblastoriginandfunctionintheinjuredheart AT hadikhalil geneticlineagetracingdefinesmyofibroblastoriginandfunctionintheinjuredheart AT malinajivey geneticlineagetracingdefinesmyofibroblastoriginandfunctionintheinjuredheart AT jasonkarch geneticlineagetracingdefinesmyofibroblastoriginandfunctionintheinjuredheart AT bryandmaliken geneticlineagetracingdefinesmyofibroblastoriginandfunctionintheinjuredheart AT robertncorrell geneticlineagetracingdefinesmyofibroblastoriginandfunctionintheinjuredheart AT matthewjbrody geneticlineagetracingdefinesmyofibroblastoriginandfunctionintheinjuredheart AT suhchinjlin geneticlineagetracingdefinesmyofibroblastoriginandfunctionintheinjuredheart AT brucejaronow geneticlineagetracingdefinesmyofibroblastoriginandfunctionintheinjuredheart AT michelledtallquist geneticlineagetracingdefinesmyofibroblastoriginandfunctionintheinjuredheart AT jefferydmolkentin geneticlineagetracingdefinesmyofibroblastoriginandfunctionintheinjuredheart
_version_	1718380358118932480

Genetic lineage tracing defines myofibroblast origin and function in the injured heart

Ejemplares similares