DACH1 inhibits breast cancer cell invasion and metastasis by down-regulating the transcription of matrix metalloproteinase 9

Abstract Human Dachshund homolog 1 (DACH1) is usually defined as a tumor suppressor, which plays an influential role in tumor growth and metastasis in a variety of cancer cells. However, the underlying mechanisms in these process are not yet fully clarified. In this study, DACH1 inhibited the invasi...

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Autores principales:	Sattout Aman, Yanan Li, Yunmeng Cheng, Yuxi Yang, Linlin Lv, Bowen Li, Kangkai Xia, Shujing Li, Huijian Wu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Publishing Group 2021
Materias:	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Cytology QH573-671
Acceso en línea:	https://doaj.org/article/2d997d1c5ee54a789d2acb52fa358b6a
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spelling	oai:doaj.org-article:2d997d1c5ee54a789d2acb52fa358b6a2021-11-14T12:12:36ZDACH1 inhibits breast cancer cell invasion and metastasis by down-regulating the transcription of matrix metalloproteinase 910.1038/s41420-021-00733-42058-7716https://doaj.org/article/2d997d1c5ee54a789d2acb52fa358b6a2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41420-021-00733-4https://doaj.org/toc/2058-7716Abstract Human Dachshund homolog 1 (DACH1) is usually defined as a tumor suppressor, which plays an influential role in tumor growth and metastasis in a variety of cancer cells. However, the underlying mechanisms in these process are not yet fully clarified. In this study, DACH1 inhibited the invasion and metastasis of breast cancer cells by decreasing MMP9 expression. Mechanistically, DACH1 represses the transcriptional level of MMP9 by interacting with p65 and c-Jun at the NF-κB and AP-1 binding sites in MMP9 promoter respectively, and the association of DACH1 and p65 promote the recruitment of HDAC1 to the NF-κB binding site in MMP9 promoter, resulting in the reduction of the acetylation level and the transcriptional activity of p65. Accordingly, the level of MMP9 was decreased. In conclusion, we found a new mechanism that DACH1 could inhibit the metastasis of breast cancer cells by inhibiting the expression of MMP9.Sattout AmanYanan LiYunmeng ChengYuxi YangLinlin LvBowen LiKangkai XiaShujing LiHuijian WuNature Publishing GrouparticleNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282CytologyQH573-671ENCell Death Discovery, Vol 7, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Cytology QH573-671
spellingShingle	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Cytology QH573-671 Sattout Aman Yanan Li Yunmeng Cheng Yuxi Yang Linlin Lv Bowen Li Kangkai Xia Shujing Li Huijian Wu DACH1 inhibits breast cancer cell invasion and metastasis by down-regulating the transcription of matrix metalloproteinase 9
description	Abstract Human Dachshund homolog 1 (DACH1) is usually defined as a tumor suppressor, which plays an influential role in tumor growth and metastasis in a variety of cancer cells. However, the underlying mechanisms in these process are not yet fully clarified. In this study, DACH1 inhibited the invasion and metastasis of breast cancer cells by decreasing MMP9 expression. Mechanistically, DACH1 represses the transcriptional level of MMP9 by interacting with p65 and c-Jun at the NF-κB and AP-1 binding sites in MMP9 promoter respectively, and the association of DACH1 and p65 promote the recruitment of HDAC1 to the NF-κB binding site in MMP9 promoter, resulting in the reduction of the acetylation level and the transcriptional activity of p65. Accordingly, the level of MMP9 was decreased. In conclusion, we found a new mechanism that DACH1 could inhibit the metastasis of breast cancer cells by inhibiting the expression of MMP9.
format	article
author	Sattout Aman Yanan Li Yunmeng Cheng Yuxi Yang Linlin Lv Bowen Li Kangkai Xia Shujing Li Huijian Wu
author_facet	Sattout Aman Yanan Li Yunmeng Cheng Yuxi Yang Linlin Lv Bowen Li Kangkai Xia Shujing Li Huijian Wu
author_sort	Sattout Aman
title	DACH1 inhibits breast cancer cell invasion and metastasis by down-regulating the transcription of matrix metalloproteinase 9
title_short	DACH1 inhibits breast cancer cell invasion and metastasis by down-regulating the transcription of matrix metalloproteinase 9
title_full	DACH1 inhibits breast cancer cell invasion and metastasis by down-regulating the transcription of matrix metalloproteinase 9
title_fullStr	DACH1 inhibits breast cancer cell invasion and metastasis by down-regulating the transcription of matrix metalloproteinase 9
title_full_unstemmed	DACH1 inhibits breast cancer cell invasion and metastasis by down-regulating the transcription of matrix metalloproteinase 9
title_sort	dach1 inhibits breast cancer cell invasion and metastasis by down-regulating the transcription of matrix metalloproteinase 9
publisher	Nature Publishing Group
publishDate	2021
url	https://doaj.org/article/2d997d1c5ee54a789d2acb52fa358b6a
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DACH1 inhibits breast cancer cell invasion and metastasis by down-regulating the transcription of matrix metalloproteinase 9

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