The Profile of Lactate, Albumin, and Lactate/Albumin Ratio as Predictors of Mortality in Sepsis Patients

Background. Sepsis is a life-threatening organ dysfunction caused by an unregulated host response to infection. Oxygenation disturbances in sepsis patients may cause increase lactate levels which is proportional to the severity of the inflammation, followed by decrease in albumin levels. Combination...

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Autor principal:	Andrea Aprilia
Formato:	article
Lenguaje:	RU
Publicado:	Sankt-Peterburg : NIIÈM imeni Pastera 2019
Materias:	lactate, albumin, lactate/albumin ratio, mortality, sepsis, prognosis Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/2d99e01aa8dc4c5eae08eec530a8a88d
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spelling	oai:doaj.org-article:2d99e01aa8dc4c5eae08eec530a8a88d2021-11-22T07:09:56ZThe Profile of Lactate, Albumin, and Lactate/Albumin Ratio as Predictors of Mortality in Sepsis Patients2220-76192313-7398https://doaj.org/article/2d99e01aa8dc4c5eae08eec530a8a88d2019-06-01T00:00:00Zhttps://www.iimmun.ru/iimm/article/view/1691https://doaj.org/toc/2220-7619https://doaj.org/toc/2313-7398Background. Sepsis is a life-threatening organ dysfunction caused by an unregulated host response to infection. Oxygenation disturbances in sepsis patients may cause increase lactate levels which is proportional to the severity of the inflammation, followed by decrease in albumin levels. Combination of these two parameters is expected to be predictor of mortality in patients with sepsis. The aim of this study is to investigate the profile of lactate, albumin, and lactate/albumin ratio as mortality predictors in patient with sepsis.Methods. This prospective cohort study was conducted in the ICU of dr. Saiful Anwar Hospital Malang from January to May 2019. Subjects were 82 patients with sepsis (SOFA score >2). Lactate and albumin levels were measured on the first day of hospitalization. Lactate levels were examined by colorimetric method, albumin were examined by BCG method. The instrument used was Cobas 501. Comparation was carried out using the T-Test/Mann-Whitney test. Prediction of mortality risk was done using relative risk (RR) determination.Results. Significant difference was observed in albumin levels between sepsis patients who survived and who died (p = 0.045). No significant differences were observed in lactate levels and lactate/albumin ratio between sepsis patients who survived and who died (p = 0.211, 0.119, respectively). Relative risks were 3.034 for lactate, 3.667 for albumin, and 4.400 for lactate/albumin ratio. Lactate levels >4.0 mmol/L have an RR value of 3.034 in predicting mortality in septic patients.Conclusions. In patients with sepsis, lactate/albumin ratio is the best variable in predicting mortality, followed by albumin and lactate value. Further study that implements repeated measurement of lactate and albumin 6 and 12 hour is required to better predict the mortality of sepsis patients.Andrea ApriliaSankt-Peterburg : NIIÈM imeni Pasteraarticlelactate, albumin, lactate/albumin ratio, mortality, sepsis, prognosisInfectious and parasitic diseasesRC109-216RUInfekciâ i Immunitet, Vol 0, Iss 0 (2019)
institution	DOAJ
collection	DOAJ
language	RU
topic	lactate, albumin, lactate/albumin ratio, mortality, sepsis, prognosis Infectious and parasitic diseases RC109-216
spellingShingle	lactate, albumin, lactate/albumin ratio, mortality, sepsis, prognosis Infectious and parasitic diseases RC109-216 Andrea Aprilia The Profile of Lactate, Albumin, and Lactate/Albumin Ratio as Predictors of Mortality in Sepsis Patients
description	Background. Sepsis is a life-threatening organ dysfunction caused by an unregulated host response to infection. Oxygenation disturbances in sepsis patients may cause increase lactate levels which is proportional to the severity of the inflammation, followed by decrease in albumin levels. Combination of these two parameters is expected to be predictor of mortality in patients with sepsis. The aim of this study is to investigate the profile of lactate, albumin, and lactate/albumin ratio as mortality predictors in patient with sepsis.Methods. This prospective cohort study was conducted in the ICU of dr. Saiful Anwar Hospital Malang from January to May 2019. Subjects were 82 patients with sepsis (SOFA score >2). Lactate and albumin levels were measured on the first day of hospitalization. Lactate levels were examined by colorimetric method, albumin were examined by BCG method. The instrument used was Cobas 501. Comparation was carried out using the T-Test/Mann-Whitney test. Prediction of mortality risk was done using relative risk (RR) determination.Results. Significant difference was observed in albumin levels between sepsis patients who survived and who died (p = 0.045). No significant differences were observed in lactate levels and lactate/albumin ratio between sepsis patients who survived and who died (p = 0.211, 0.119, respectively). Relative risks were 3.034 for lactate, 3.667 for albumin, and 4.400 for lactate/albumin ratio. Lactate levels >4.0 mmol/L have an RR value of 3.034 in predicting mortality in septic patients.Conclusions. In patients with sepsis, lactate/albumin ratio is the best variable in predicting mortality, followed by albumin and lactate value. Further study that implements repeated measurement of lactate and albumin 6 and 12 hour is required to better predict the mortality of sepsis patients.
format	article
author	Andrea Aprilia
author_facet	Andrea Aprilia
author_sort	Andrea Aprilia
title	The Profile of Lactate, Albumin, and Lactate/Albumin Ratio as Predictors of Mortality in Sepsis Patients
title_short	The Profile of Lactate, Albumin, and Lactate/Albumin Ratio as Predictors of Mortality in Sepsis Patients
title_full	The Profile of Lactate, Albumin, and Lactate/Albumin Ratio as Predictors of Mortality in Sepsis Patients
title_fullStr	The Profile of Lactate, Albumin, and Lactate/Albumin Ratio as Predictors of Mortality in Sepsis Patients
title_full_unstemmed	The Profile of Lactate, Albumin, and Lactate/Albumin Ratio as Predictors of Mortality in Sepsis Patients
title_sort	profile of lactate, albumin, and lactate/albumin ratio as predictors of mortality in sepsis patients
publisher	Sankt-Peterburg : NIIÈM imeni Pastera
publishDate	2019
url	https://doaj.org/article/2d99e01aa8dc4c5eae08eec530a8a88d
work_keys_str_mv	AT andreaaprilia theprofileoflactatealbuminandlactatealbuminratioaspredictorsofmortalityinsepsispatients AT andreaaprilia profileoflactatealbuminandlactatealbuminratioaspredictorsofmortalityinsepsispatients
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The Profile of Lactate, Albumin, and Lactate/Albumin Ratio as Predictors of Mortality in Sepsis Patients

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