Amine-Coated Carbon Dots (NH2-FCDs) as Novel Antimicrobial Agent for Gram-Negative Bacteria

Multidrug resistance (MDR) is a major concern in battling infectious bacterial diseases. The overuse of antibiotics contributes to the emergence of resistance by eradicating the drug-sensitive strains, leaving behind the resistant strains that multiply without any competition. Nanoparticles are beco...

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Autores principales:	Asmita Devkota, Anju Pandey, Zeinab Yadegari, Korsi Dumenyo, Ali Taheri
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	carbon dots antimicrobial MDR gram-negative amine coated Chemical technology TP1-1185
Acceso en línea:	https://doaj.org/article/2d9a57ce3e9c4d8b9dbeb0c55a7ab36c
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spelling	oai:doaj.org-article:2d9a57ce3e9c4d8b9dbeb0c55a7ab36c2021-11-16T05:43:49ZAmine-Coated Carbon Dots (NH2-FCDs) as Novel Antimicrobial Agent for Gram-Negative Bacteria2673-301310.3389/fnano.2021.768487https://doaj.org/article/2d9a57ce3e9c4d8b9dbeb0c55a7ab36c2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fnano.2021.768487/fullhttps://doaj.org/toc/2673-3013Multidrug resistance (MDR) is a major concern in battling infectious bacterial diseases. The overuse of antibiotics contributes to the emergence of resistance by eradicating the drug-sensitive strains, leaving behind the resistant strains that multiply without any competition. Nanoparticles are becoming popular as novel antimicrobial agents that follow a different mode of action from standard antibiotics and are therefore desirable against MDR bacteria. In this study, we synthesized carbon dots from different precursors including glucosamine HCL (GlcNH2·HCl) and 4,7,10-trioxa-1,13-tridecanediamine (TTDDA, and studied their antimicrobial effects in a diverse list of Gram-negative bacteria including Escherichia coli, Pseudomonas syringae, Salmonella enterica subsp. enterica serovar Typhimurium, Pectobacterium carotovorum, Agrobacterium tumefaciens, and Agrobacterium rhizogenes. We demonstrated the antimicrobial properties of these carbon dots against these bacteria and provided the optimum concentration and incubation times for each bacterial species. Our findings indicated that not all carbon dots carry antimicrobial properties, and there is also a variation between different bacterial species in their resistance against these carbon dots.Asmita DevkotaAnju PandeyZeinab YadegariKorsi DumenyoAli TaheriFrontiers Media S.A.articlecarbon dotsantimicrobialMDRgram-negativeamine coatedChemical technologyTP1-1185ENFrontiers in Nanotechnology, Vol 3 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	carbon dots antimicrobial MDR gram-negative amine coated Chemical technology TP1-1185
spellingShingle	carbon dots antimicrobial MDR gram-negative amine coated Chemical technology TP1-1185 Asmita Devkota Anju Pandey Zeinab Yadegari Korsi Dumenyo Ali Taheri Amine-Coated Carbon Dots (NH2-FCDs) as Novel Antimicrobial Agent for Gram-Negative Bacteria
description	Multidrug resistance (MDR) is a major concern in battling infectious bacterial diseases. The overuse of antibiotics contributes to the emergence of resistance by eradicating the drug-sensitive strains, leaving behind the resistant strains that multiply without any competition. Nanoparticles are becoming popular as novel antimicrobial agents that follow a different mode of action from standard antibiotics and are therefore desirable against MDR bacteria. In this study, we synthesized carbon dots from different precursors including glucosamine HCL (GlcNH2·HCl) and 4,7,10-trioxa-1,13-tridecanediamine (TTDDA, and studied their antimicrobial effects in a diverse list of Gram-negative bacteria including Escherichia coli, Pseudomonas syringae, Salmonella enterica subsp. enterica serovar Typhimurium, Pectobacterium carotovorum, Agrobacterium tumefaciens, and Agrobacterium rhizogenes. We demonstrated the antimicrobial properties of these carbon dots against these bacteria and provided the optimum concentration and incubation times for each bacterial species. Our findings indicated that not all carbon dots carry antimicrobial properties, and there is also a variation between different bacterial species in their resistance against these carbon dots.
format	article
author	Asmita Devkota Anju Pandey Zeinab Yadegari Korsi Dumenyo Ali Taheri
author_facet	Asmita Devkota Anju Pandey Zeinab Yadegari Korsi Dumenyo Ali Taheri
author_sort	Asmita Devkota
title	Amine-Coated Carbon Dots (NH2-FCDs) as Novel Antimicrobial Agent for Gram-Negative Bacteria
title_short	Amine-Coated Carbon Dots (NH2-FCDs) as Novel Antimicrobial Agent for Gram-Negative Bacteria
title_full	Amine-Coated Carbon Dots (NH2-FCDs) as Novel Antimicrobial Agent for Gram-Negative Bacteria
title_fullStr	Amine-Coated Carbon Dots (NH2-FCDs) as Novel Antimicrobial Agent for Gram-Negative Bacteria
title_full_unstemmed	Amine-Coated Carbon Dots (NH2-FCDs) as Novel Antimicrobial Agent for Gram-Negative Bacteria
title_sort	amine-coated carbon dots (nh2-fcds) as novel antimicrobial agent for gram-negative bacteria
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/2d9a57ce3e9c4d8b9dbeb0c55a7ab36c
work_keys_str_mv	AT asmitadevkota aminecoatedcarbondotsnh2fcdsasnovelantimicrobialagentforgramnegativebacteria AT anjupandey aminecoatedcarbondotsnh2fcdsasnovelantimicrobialagentforgramnegativebacteria AT zeinabyadegari aminecoatedcarbondotsnh2fcdsasnovelantimicrobialagentforgramnegativebacteria AT korsidumenyo aminecoatedcarbondotsnh2fcdsasnovelantimicrobialagentforgramnegativebacteria AT alitaheri aminecoatedcarbondotsnh2fcdsasnovelantimicrobialagentforgramnegativebacteria
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Amine-Coated Carbon Dots (NH2-FCDs) as Novel Antimicrobial Agent for Gram-Negative Bacteria

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