Non-synaptic Cell-Autonomous Mechanisms Underlie Neuronal Hyperactivity in a Genetic Model of PIK3CA-Driven Intractable Epilepsy

Patients harboring mutations in the PI3K-AKT-MTOR pathway-encoding genes often develop a spectrum of neurodevelopmental disorders including epilepsy. A significant proportion remains unresponsive to conventional anti-seizure medications. Understanding mutation-specific pathophysiology is thus critic...

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Autores principales: Achira Roy, Victor Z. Han, Angela M. Bard, Devin T. Wehle, Stephen E. P. Smith, Jan-Marino Ramirez, Franck Kalume, Kathleen J. Millen
Formato: article
Lenguaje:EN
Publicado: Frontiers Media S.A. 2021
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Acceso en línea:https://doaj.org/article/2d9e75212ff44739a7d5a2363a17616b
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