A genome-wide association study identifies six novel risk loci for primary biliary cholangitis

Primary biliary cholangitis is an autoimmune liver disease. Here, the authors show that variants in interleukin genes which potentially deregulate their expression are associated with this condition, and suggest that the IL21 signalling pathway may have a role in disease aetiology.

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Autores principales:	Fang Qiu, Ruqi Tang, Xianbo Zuo, Xingjuan Shi, Yiran Wei, Xiaodong Zheng, Yaping Dai, Yuhua Gong, Lan Wang, Ping Xu, Xiang Zhu, Jian Wu, Chongxu Han, Yueqiu Gao, Kui Zhang, Yuzhang Jiang, Jianbo Zhou, Youlin Shao, Zhigang Hu, Ye Tian, Haiyan Zhang, Na Dai, Lei Liu, Xudong Wu, Weifeng Zhao, Xiaomin Zhang, Zhidong Zang, Jinshan Nie, Weihao Sun, Yi Zhao, Yuan Mao, Po Jiang, Hualiang Ji, Qing Dong, Junming Li, Zhenzhong Li, Xinli Bai, Li Li, Maosong Lin, Ming Dong, Jinxin Li, Ping Zhu, Chan Wang, Yanqiu Zhang, Peng Jiang, Yujue Wang, Rohil Jawed, Jing Xu, Yu Zhang, Qixia Wang, Yue Yang, Fan Yang, Min Lian, Xiang Jiang, Xiao Xiao, Yanmei Li, Jingyuan Fang, Dekai Qiu, Zhen Zhu, Hong Qiu, Jianqiong Zhang, Wenyan Tian, Sufang Chen, Ling Jiang, Bing Ji, Ping Li, Guochang Chen, Tianxue Wu, Yan Sun, Jianjiang Yu, Huijun Tang, Michun He, Min Xia, Hao Pei, Lihua Huang, Zhuye Qing, Jianfang Wu, Qinghai Huang, Junhai Han, Wei Xie, Zhongsheng Sun, Jian Guo, Gengsheng He, M. Eric Gershwin, Zhexiong Lian, Xiang Liu, Michael F. Seldin, Xiangdong Liu, Weichang Chen, Xiong Ma
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2d9f1e41b1654d168ba642000f183a48
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spelling	oai:doaj.org-article:2d9f1e41b1654d168ba642000f183a482021-12-02T14:42:38ZA genome-wide association study identifies six novel risk loci for primary biliary cholangitis10.1038/ncomms148282041-1723https://doaj.org/article/2d9f1e41b1654d168ba642000f183a482017-04-01T00:00:00Zhttps://doi.org/10.1038/ncomms14828https://doaj.org/toc/2041-1723Primary biliary cholangitis is an autoimmune liver disease. Here, the authors show that variants in interleukin genes which potentially deregulate their expression are associated with this condition, and suggest that the IL21 signalling pathway may have a role in disease aetiology.Fang QiuRuqi TangXianbo ZuoXingjuan ShiYiran WeiXiaodong ZhengYaping DaiYuhua GongLan WangPing XuXiang ZhuJian WuChongxu HanYueqiu GaoKui ZhangYuzhang JiangJianbo ZhouYoulin ShaoZhigang HuYe TianHaiyan ZhangNa DaiLei LiuXudong WuWeifeng ZhaoXiaomin ZhangZhidong ZangJinshan NieWeihao SunYi ZhaoYuan MaoPo JiangHualiang JiQing DongJunming LiZhenzhong LiXinli BaiLi LiMaosong LinMing DongJinxin LiPing ZhuChan WangYanqiu ZhangPeng JiangYujue WangRohil JawedJing XuYu ZhangQixia WangYue YangFan YangMin LianXiang JiangXiao XiaoYanmei LiJingyuan FangDekai QiuZhen ZhuHong QiuJianqiong ZhangWenyan TianSufang ChenLing JiangBing JiPing LiGuochang ChenTianxue WuYan SunJianjiang YuHuijun TangMichun HeMin XiaHao PeiLihua HuangZhuye QingJianfang WuQinghai HuangJunhai HanWei XieZhongsheng SunJian GuoGengsheng HeM. Eric GershwinZhexiong LianXiang LiuMichael F. SeldinXiangdong LiuWeichang ChenXiong MaNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Fang Qiu Ruqi Tang Xianbo Zuo Xingjuan Shi Yiran Wei Xiaodong Zheng Yaping Dai Yuhua Gong Lan Wang Ping Xu Xiang Zhu Jian Wu Chongxu Han Yueqiu Gao Kui Zhang Yuzhang Jiang Jianbo Zhou Youlin Shao Zhigang Hu Ye Tian Haiyan Zhang Na Dai Lei Liu Xudong Wu Weifeng Zhao Xiaomin Zhang Zhidong Zang Jinshan Nie Weihao Sun Yi Zhao Yuan Mao Po Jiang Hualiang Ji Qing Dong Junming Li Zhenzhong Li Xinli Bai Li Li Maosong Lin Ming Dong Jinxin Li Ping Zhu Chan Wang Yanqiu Zhang Peng Jiang Yujue Wang Rohil Jawed Jing Xu Yu Zhang Qixia Wang Yue Yang Fan Yang Min Lian Xiang Jiang Xiao Xiao Yanmei Li Jingyuan Fang Dekai Qiu Zhen Zhu Hong Qiu Jianqiong Zhang Wenyan Tian Sufang Chen Ling Jiang Bing Ji Ping Li Guochang Chen Tianxue Wu Yan Sun Jianjiang Yu Huijun Tang Michun He Min Xia Hao Pei Lihua Huang Zhuye Qing Jianfang Wu Qinghai Huang Junhai Han Wei Xie Zhongsheng Sun Jian Guo Gengsheng He M. Eric Gershwin Zhexiong Lian Xiang Liu Michael F. Seldin Xiangdong Liu Weichang Chen Xiong Ma A genome-wide association study identifies six novel risk loci for primary biliary cholangitis
description	Primary biliary cholangitis is an autoimmune liver disease. Here, the authors show that variants in interleukin genes which potentially deregulate their expression are associated with this condition, and suggest that the IL21 signalling pathway may have a role in disease aetiology.
format	article
author	Fang Qiu Ruqi Tang Xianbo Zuo Xingjuan Shi Yiran Wei Xiaodong Zheng Yaping Dai Yuhua Gong Lan Wang Ping Xu Xiang Zhu Jian Wu Chongxu Han Yueqiu Gao Kui Zhang Yuzhang Jiang Jianbo Zhou Youlin Shao Zhigang Hu Ye Tian Haiyan Zhang Na Dai Lei Liu Xudong Wu Weifeng Zhao Xiaomin Zhang Zhidong Zang Jinshan Nie Weihao Sun Yi Zhao Yuan Mao Po Jiang Hualiang Ji Qing Dong Junming Li Zhenzhong Li Xinli Bai Li Li Maosong Lin Ming Dong Jinxin Li Ping Zhu Chan Wang Yanqiu Zhang Peng Jiang Yujue Wang Rohil Jawed Jing Xu Yu Zhang Qixia Wang Yue Yang Fan Yang Min Lian Xiang Jiang Xiao Xiao Yanmei Li Jingyuan Fang Dekai Qiu Zhen Zhu Hong Qiu Jianqiong Zhang Wenyan Tian Sufang Chen Ling Jiang Bing Ji Ping Li Guochang Chen Tianxue Wu Yan Sun Jianjiang Yu Huijun Tang Michun He Min Xia Hao Pei Lihua Huang Zhuye Qing Jianfang Wu Qinghai Huang Junhai Han Wei Xie Zhongsheng Sun Jian Guo Gengsheng He M. Eric Gershwin Zhexiong Lian Xiang Liu Michael F. Seldin Xiangdong Liu Weichang Chen Xiong Ma
author_facet	Fang Qiu Ruqi Tang Xianbo Zuo Xingjuan Shi Yiran Wei Xiaodong Zheng Yaping Dai Yuhua Gong Lan Wang Ping Xu Xiang Zhu Jian Wu Chongxu Han Yueqiu Gao Kui Zhang Yuzhang Jiang Jianbo Zhou Youlin Shao Zhigang Hu Ye Tian Haiyan Zhang Na Dai Lei Liu Xudong Wu Weifeng Zhao Xiaomin Zhang Zhidong Zang Jinshan Nie Weihao Sun Yi Zhao Yuan Mao Po Jiang Hualiang Ji Qing Dong Junming Li Zhenzhong Li Xinli Bai Li Li Maosong Lin Ming Dong Jinxin Li Ping Zhu Chan Wang Yanqiu Zhang Peng Jiang Yujue Wang Rohil Jawed Jing Xu Yu Zhang Qixia Wang Yue Yang Fan Yang Min Lian Xiang Jiang Xiao Xiao Yanmei Li Jingyuan Fang Dekai Qiu Zhen Zhu Hong Qiu Jianqiong Zhang Wenyan Tian Sufang Chen Ling Jiang Bing Ji Ping Li Guochang Chen Tianxue Wu Yan Sun Jianjiang Yu Huijun Tang Michun He Min Xia Hao Pei Lihua Huang Zhuye Qing Jianfang Wu Qinghai Huang Junhai Han Wei Xie Zhongsheng Sun Jian Guo Gengsheng He M. Eric Gershwin Zhexiong Lian Xiang Liu Michael F. Seldin Xiangdong Liu Weichang Chen Xiong Ma
author_sort	Fang Qiu
title	A genome-wide association study identifies six novel risk loci for primary biliary cholangitis
title_short	A genome-wide association study identifies six novel risk loci for primary biliary cholangitis
title_full	A genome-wide association study identifies six novel risk loci for primary biliary cholangitis
title_fullStr	A genome-wide association study identifies six novel risk loci for primary biliary cholangitis
title_full_unstemmed	A genome-wide association study identifies six novel risk loci for primary biliary cholangitis
title_sort	genome-wide association study identifies six novel risk loci for primary biliary cholangitis
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/2d9f1e41b1654d168ba642000f183a48
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A genome-wide association study identifies six novel risk loci for primary biliary cholangitis

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