Composite trait Mendelian randomization reveals distinct metabolic and lifestyle consequences of differences in body shape

Jonathan Sulc et al. use principal component analysis and Mendelian randomization to conduct a comprehensive analysis of 14 body morphology metrics using data from the UK Biobank. Their results suggest that body size and adiposity have distinct impacts on obesity-related outcomes and highlight a BMI...

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Autores principales:	Jonathan Sulc, Anthony Sonrel, Ninon Mounier, Chiara Auwerx, Eirini Marouli, Liza Darrous, Bogdan Draganski, Tuomas O. Kilpeläinen, Peter Joshi, Ruth J. F. Loos, Zoltán Kutalik
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/2da3bcef86474fd78e31f2affd509a21
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spelling	oai:doaj.org-article:2da3bcef86474fd78e31f2affd509a212021-12-02T17:24:11ZComposite trait Mendelian randomization reveals distinct metabolic and lifestyle consequences of differences in body shape10.1038/s42003-021-02550-y2399-3642https://doaj.org/article/2da3bcef86474fd78e31f2affd509a212021-09-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02550-yhttps://doaj.org/toc/2399-3642Jonathan Sulc et al. use principal component analysis and Mendelian randomization to conduct a comprehensive analysis of 14 body morphology metrics using data from the UK Biobank. Their results suggest that body size and adiposity have distinct impacts on obesity-related outcomes and highlight a BMI-neutral component affecting body fat distribution, providing further insight into the genetic basis of body shape and its consequences on human health and lifestyle.Jonathan SulcAnthony SonrelNinon MounierChiara AuwerxEirini MarouliLiza DarrousBogdan DraganskiTuomas O. KilpeläinenPeter JoshiRuth J. F. LoosZoltán KutalikNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Jonathan Sulc Anthony Sonrel Ninon Mounier Chiara Auwerx Eirini Marouli Liza Darrous Bogdan Draganski Tuomas O. Kilpeläinen Peter Joshi Ruth J. F. Loos Zoltán Kutalik Composite trait Mendelian randomization reveals distinct metabolic and lifestyle consequences of differences in body shape
description	Jonathan Sulc et al. use principal component analysis and Mendelian randomization to conduct a comprehensive analysis of 14 body morphology metrics using data from the UK Biobank. Their results suggest that body size and adiposity have distinct impacts on obesity-related outcomes and highlight a BMI-neutral component affecting body fat distribution, providing further insight into the genetic basis of body shape and its consequences on human health and lifestyle.
format	article
author	Jonathan Sulc Anthony Sonrel Ninon Mounier Chiara Auwerx Eirini Marouli Liza Darrous Bogdan Draganski Tuomas O. Kilpeläinen Peter Joshi Ruth J. F. Loos Zoltán Kutalik
author_facet	Jonathan Sulc Anthony Sonrel Ninon Mounier Chiara Auwerx Eirini Marouli Liza Darrous Bogdan Draganski Tuomas O. Kilpeläinen Peter Joshi Ruth J. F. Loos Zoltán Kutalik
author_sort	Jonathan Sulc
title	Composite trait Mendelian randomization reveals distinct metabolic and lifestyle consequences of differences in body shape
title_short	Composite trait Mendelian randomization reveals distinct metabolic and lifestyle consequences of differences in body shape
title_full	Composite trait Mendelian randomization reveals distinct metabolic and lifestyle consequences of differences in body shape
title_fullStr	Composite trait Mendelian randomization reveals distinct metabolic and lifestyle consequences of differences in body shape
title_full_unstemmed	Composite trait Mendelian randomization reveals distinct metabolic and lifestyle consequences of differences in body shape
title_sort	composite trait mendelian randomization reveals distinct metabolic and lifestyle consequences of differences in body shape
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/2da3bcef86474fd78e31f2affd509a21
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Composite trait Mendelian randomization reveals distinct metabolic and lifestyle consequences of differences in body shape

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