A SARS-CoV-2 antibody curbs viral nucleocapsid protein-induced complement hyperactivation

While SARS-CoV-2 S protein targeting monoclonal antibodies (mAbs) are well studied, little is known about N protein-targeting mAbs. Here, Kang et al. provide the crystal structure of the N protein RNA binding domain with a mAb derived from a convalescent patient and show that it compromises the N pr...

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Autores principales:	Sisi Kang, Mei Yang, Suhua He, Yueming Wang, Xiaoxue Chen, Yao-Qing Chen, Zhongsi Hong, Jing Liu, Guanmin Jiang, Qiuyue Chen, Ziliang Zhou, Zhechong Zhou, Zhaoxia Huang, Xi Huang, Huanhuan He, Weihong Zheng, Hua-Xin Liao, Fei Xiao, Hong Shan, Shoudeng Chen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2da4437eaadf4c83b43c76e7bb299f22
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spelling	oai:doaj.org-article:2da4437eaadf4c83b43c76e7bb299f222021-12-02T16:58:20ZA SARS-CoV-2 antibody curbs viral nucleocapsid protein-induced complement hyperactivation10.1038/s41467-021-23036-92041-1723https://doaj.org/article/2da4437eaadf4c83b43c76e7bb299f222021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23036-9https://doaj.org/toc/2041-1723While SARS-CoV-2 S protein targeting monoclonal antibodies (mAbs) are well studied, little is known about N protein-targeting mAbs. Here, Kang et al. provide the crystal structure of the N protein RNA binding domain with a mAb derived from a convalescent patient and show that it compromises the N protein-induced complement hyperactivation.Sisi KangMei YangSuhua HeYueming WangXiaoxue ChenYao-Qing ChenZhongsi HongJing LiuGuanmin JiangQiuyue ChenZiliang ZhouZhechong ZhouZhaoxia HuangXi HuangHuanhuan HeWeihong ZhengHua-Xin LiaoFei XiaoHong ShanShoudeng ChenNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sisi Kang Mei Yang Suhua He Yueming Wang Xiaoxue Chen Yao-Qing Chen Zhongsi Hong Jing Liu Guanmin Jiang Qiuyue Chen Ziliang Zhou Zhechong Zhou Zhaoxia Huang Xi Huang Huanhuan He Weihong Zheng Hua-Xin Liao Fei Xiao Hong Shan Shoudeng Chen A SARS-CoV-2 antibody curbs viral nucleocapsid protein-induced complement hyperactivation
description	While SARS-CoV-2 S protein targeting monoclonal antibodies (mAbs) are well studied, little is known about N protein-targeting mAbs. Here, Kang et al. provide the crystal structure of the N protein RNA binding domain with a mAb derived from a convalescent patient and show that it compromises the N protein-induced complement hyperactivation.
format	article
author	Sisi Kang Mei Yang Suhua He Yueming Wang Xiaoxue Chen Yao-Qing Chen Zhongsi Hong Jing Liu Guanmin Jiang Qiuyue Chen Ziliang Zhou Zhechong Zhou Zhaoxia Huang Xi Huang Huanhuan He Weihong Zheng Hua-Xin Liao Fei Xiao Hong Shan Shoudeng Chen
author_facet	Sisi Kang Mei Yang Suhua He Yueming Wang Xiaoxue Chen Yao-Qing Chen Zhongsi Hong Jing Liu Guanmin Jiang Qiuyue Chen Ziliang Zhou Zhechong Zhou Zhaoxia Huang Xi Huang Huanhuan He Weihong Zheng Hua-Xin Liao Fei Xiao Hong Shan Shoudeng Chen
author_sort	Sisi Kang
title	A SARS-CoV-2 antibody curbs viral nucleocapsid protein-induced complement hyperactivation
title_short	A SARS-CoV-2 antibody curbs viral nucleocapsid protein-induced complement hyperactivation
title_full	A SARS-CoV-2 antibody curbs viral nucleocapsid protein-induced complement hyperactivation
title_fullStr	A SARS-CoV-2 antibody curbs viral nucleocapsid protein-induced complement hyperactivation
title_full_unstemmed	A SARS-CoV-2 antibody curbs viral nucleocapsid protein-induced complement hyperactivation
title_sort	sars-cov-2 antibody curbs viral nucleocapsid protein-induced complement hyperactivation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/2da4437eaadf4c83b43c76e7bb299f22
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A SARS-CoV-2 antibody curbs viral nucleocapsid protein-induced complement hyperactivation

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