Intellectual disability-associated UNC80 mutations reveal inter-subunit interaction and dendritic function of the NALCN channel complex

The sodium-leak channel NALCN controls the resting membrane potentials of neurons. Here, the authors identified two subunits of NALCN, UNC80 and UNC79. Domains in UNC80, which are mutated in individuals with intellectual disability, interact to achieve the dendritic localization of NALCN complex.

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Autores principales:	Jinhong Wie, Apoorva Bharthur, Morgan Wolfgang, Vinodh Narayanan, Keri Ramsey, C4RCD Research Group, Kimberly Aranda, Qi Zhang, Yandong Zhou, Dejian Ren
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2da46ae4d7614b2cae274917ec573a89
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spelling	oai:doaj.org-article:2da46ae4d7614b2cae274917ec573a892021-12-02T16:13:39ZIntellectual disability-associated UNC80 mutations reveal inter-subunit interaction and dendritic function of the NALCN channel complex10.1038/s41467-020-17105-82041-1723https://doaj.org/article/2da46ae4d7614b2cae274917ec573a892020-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17105-8https://doaj.org/toc/2041-1723The sodium-leak channel NALCN controls the resting membrane potentials of neurons. Here, the authors identified two subunits of NALCN, UNC80 and UNC79. Domains in UNC80, which are mutated in individuals with intellectual disability, interact to achieve the dendritic localization of NALCN complex.Jinhong WieApoorva BharthurMorgan WolfgangVinodh NarayananKeri RamseyC4RCD Research GroupKimberly ArandaQi ZhangYandong ZhouDejian RenNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jinhong Wie Apoorva Bharthur Morgan Wolfgang Vinodh Narayanan Keri Ramsey C4RCD Research Group Kimberly Aranda Qi Zhang Yandong Zhou Dejian Ren Intellectual disability-associated UNC80 mutations reveal inter-subunit interaction and dendritic function of the NALCN channel complex
description	The sodium-leak channel NALCN controls the resting membrane potentials of neurons. Here, the authors identified two subunits of NALCN, UNC80 and UNC79. Domains in UNC80, which are mutated in individuals with intellectual disability, interact to achieve the dendritic localization of NALCN complex.
format	article
author	Jinhong Wie Apoorva Bharthur Morgan Wolfgang Vinodh Narayanan Keri Ramsey C4RCD Research Group Kimberly Aranda Qi Zhang Yandong Zhou Dejian Ren
author_facet	Jinhong Wie Apoorva Bharthur Morgan Wolfgang Vinodh Narayanan Keri Ramsey C4RCD Research Group Kimberly Aranda Qi Zhang Yandong Zhou Dejian Ren
author_sort	Jinhong Wie
title	Intellectual disability-associated UNC80 mutations reveal inter-subunit interaction and dendritic function of the NALCN channel complex
title_short	Intellectual disability-associated UNC80 mutations reveal inter-subunit interaction and dendritic function of the NALCN channel complex
title_full	Intellectual disability-associated UNC80 mutations reveal inter-subunit interaction and dendritic function of the NALCN channel complex
title_fullStr	Intellectual disability-associated UNC80 mutations reveal inter-subunit interaction and dendritic function of the NALCN channel complex
title_full_unstemmed	Intellectual disability-associated UNC80 mutations reveal inter-subunit interaction and dendritic function of the NALCN channel complex
title_sort	intellectual disability-associated unc80 mutations reveal inter-subunit interaction and dendritic function of the nalcn channel complex
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/2da46ae4d7614b2cae274917ec573a89
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Intellectual disability-associated UNC80 mutations reveal inter-subunit interaction and dendritic function of the NALCN channel complex

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