The effects of the COVID-19 lockdown on severe asthma in patients taking biologic therapy and air pollution in Riyadh
BACKGROUND: The curfews and lockdowns imposed during the COVID-19 pandemic may decreased the volume of traffic and reduced air pollution. In addition, social distancing measures may contribute to reducing infection and asthma exacerbation.OBJECTIVE: The objective of this study was to assess asthma c...
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Wolters Kluwer Medknow Publications
2021
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oai:doaj.org-article:2da85f2ceb4a485391632b9291a089612021-11-12T10:08:17ZThe effects of the COVID-19 lockdown on severe asthma in patients taking biologic therapy and air pollution in Riyadh1817-17371998-355710.4103/atm.atm_559_20https://doaj.org/article/2da85f2ceb4a485391632b9291a089612021-01-01T00:00:00Zhttp://www.thoracicmedicine.org/article.asp?issn=1817-1737;year=2021;volume=16;issue=4;spage=354;epage=360;aulast=Ayazhttps://doaj.org/toc/1817-1737https://doaj.org/toc/1998-3557BACKGROUND: The curfews and lockdowns imposed during the COVID-19 pandemic may decreased the volume of traffic and reduced air pollution. In addition, social distancing measures may contribute to reducing infection and asthma exacerbation.OBJECTIVE: The objective of this study was to assess asthma control and asthma medication use among severe asthmatics on biologics before and after the COVID-19 pandemic.METHODS: This is a cross-sectional survey study of patients with severe asthma receiving biologic therapy at King Abdulaziz Medical City-Riyadh, Saudi Arabia. We looked at the effects of the COVID-19 lockdown on this cohort of severe asthmatics on biologic therapy from March till June 2020 over a period of 12 weeks. We investigated changes in patients' symptoms and asthma control using the asthma control test (ACT) score and other parameters including emergency department visits, hospitalizations, use of oral prednisolone, changes in inhaler therapy, frequency of bronchodilator use, and patient perception of their symptoms before and after the lockdown period.RESULTS: A total of 56, Female 39 (69%), mean age ± SD 47.4 ± 13.8 years. The duration of bronchial asthma since diagnosis ranged from 4 to 30 years. Most patients had been treated with omalizumab (47, 84%); the rest received mepolizumab (7, 12.5%) and dupilumab (2, 3.6%). All these patients had been on biologic therapy for 5 months, ranging from 5 to 120 months. Most of the patients (45, 80.4%) agreed that their symptoms of asthma had improved with biologic therapy. Most of the patients felt that overall asthma symptoms are better after curfew and lockdown 28 (50%). Less use of bronchodilators postcurfew was reported in 38% of the patients. Asthma control (≥20) using ACT score was significantly higher among patients in postcurfew and lockdown period compared to precurfew period 34 (61.7%) and 23 (41%) (P = 0.001), respectively.CONCLUSIONS: Asthma control was better postcurfew and lockdown. A decrease in air pollution and social distances may be a contributing factor.Khan Mohammad AyazRajendram RajkumarAl-Ghamdi BasmaAl-Jahdaly EmadAL-Harbi AbdullahHayyan HajarObaidi Mostafa MohammadHamdan AL-JahdaliWolters Kluwer Medknow Publicationsarticlebiologicscovid-19severe asthmaDiseases of the circulatory (Cardiovascular) systemRC666-701Diseases of the respiratory systemRC705-779ENAnnals of Thoracic Medicine, Vol 16, Iss 4, Pp 354-360 (2021) |
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biologics covid-19 severe asthma Diseases of the circulatory (Cardiovascular) system RC666-701 Diseases of the respiratory system RC705-779 |
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biologics covid-19 severe asthma Diseases of the circulatory (Cardiovascular) system RC666-701 Diseases of the respiratory system RC705-779 Khan Mohammad Ayaz Rajendram Rajkumar Al-Ghamdi Basma Al-Jahdaly Emad AL-Harbi Abdullah Hayyan Hajar Obaidi Mostafa Mohammad Hamdan AL-Jahdali The effects of the COVID-19 lockdown on severe asthma in patients taking biologic therapy and air pollution in Riyadh |
| description |
BACKGROUND: The curfews and lockdowns imposed during the COVID-19 pandemic may decreased the volume of traffic and reduced air pollution. In addition, social distancing measures may contribute to reducing infection and asthma exacerbation.OBJECTIVE: The objective of this study was to assess asthma control and asthma medication use among severe asthmatics on biologics before and after the COVID-19 pandemic.METHODS: This is a cross-sectional survey study of patients with severe asthma receiving biologic therapy at King Abdulaziz Medical City-Riyadh, Saudi Arabia. We looked at the effects of the COVID-19 lockdown on this cohort of severe asthmatics on biologic therapy from March till June 2020 over a period of 12 weeks. We investigated changes in patients' symptoms and asthma control using the asthma control test (ACT) score and other parameters including emergency department visits, hospitalizations, use of oral prednisolone, changes in inhaler therapy, frequency of bronchodilator use, and patient perception of their symptoms before and after the lockdown period.RESULTS: A total of 56, Female 39 (69%), mean age ± SD 47.4 ± 13.8 years. The duration of bronchial asthma since diagnosis ranged from 4 to 30 years. Most patients had been treated with omalizumab (47, 84%); the rest received mepolizumab (7, 12.5%) and dupilumab (2, 3.6%). All these patients had been on biologic therapy for 5 months, ranging from 5 to 120 months. Most of the patients (45, 80.4%) agreed that their symptoms of asthma had improved with biologic therapy. Most of the patients felt that overall asthma symptoms are better after curfew and lockdown 28 (50%). Less use of bronchodilators postcurfew was reported in 38% of the patients. Asthma control (≥20) using ACT score was significantly higher among patients in postcurfew and lockdown period compared to precurfew period 34 (61.7%) and 23 (41%) (P = 0.001), respectively.CONCLUSIONS: Asthma control was better postcurfew and lockdown. A decrease in air pollution and social distances may be a contributing factor. |
| format |
article |
| author |
Khan Mohammad Ayaz Rajendram Rajkumar Al-Ghamdi Basma Al-Jahdaly Emad AL-Harbi Abdullah Hayyan Hajar Obaidi Mostafa Mohammad Hamdan AL-Jahdali |
| author_facet |
Khan Mohammad Ayaz Rajendram Rajkumar Al-Ghamdi Basma Al-Jahdaly Emad AL-Harbi Abdullah Hayyan Hajar Obaidi Mostafa Mohammad Hamdan AL-Jahdali |
| author_sort |
Khan Mohammad Ayaz |
| title |
The effects of the COVID-19 lockdown on severe asthma in patients taking biologic therapy and air pollution in Riyadh |
| title_short |
The effects of the COVID-19 lockdown on severe asthma in patients taking biologic therapy and air pollution in Riyadh |
| title_full |
The effects of the COVID-19 lockdown on severe asthma in patients taking biologic therapy and air pollution in Riyadh |
| title_fullStr |
The effects of the COVID-19 lockdown on severe asthma in patients taking biologic therapy and air pollution in Riyadh |
| title_full_unstemmed |
The effects of the COVID-19 lockdown on severe asthma in patients taking biologic therapy and air pollution in Riyadh |
| title_sort |
effects of the covid-19 lockdown on severe asthma in patients taking biologic therapy and air pollution in riyadh |
| publisher |
Wolters Kluwer Medknow Publications |
| publishDate |
2021 |
| url |
https://doaj.org/article/2da85f2ceb4a485391632b9291a08961 |
| work_keys_str_mv |
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