Tissue Type Differences in ABCB1 Expression and Paclitaxel Tissue Pharmacokinetics in Patients With Esophageal Cancer

Background: Data from previous work suggests that there is no correlation between systemic (plasma) paclitaxel exposure and efficacy in patients treated for esophageal cancer. In this trial, we investigated ATP-binding cassette efflux transporter expression and intratumoral pharmacokinetics of pacli...

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Autores principales:	Ruben A. G. van Eerden, Leni van Doorn, Femke M. de Man, Niels Heersche, Michail Doukas, Thierry P. P. van den Bosch, Esther Oomen-de Hoop, Peter de Bruijn, Sander Bins, Eman Ibrahim, Suzan Nikkessen, Lena E. Friberg, Stijn L. W. Koolen, Manon C. W. Spaander, Ron H. J. Mathijssen
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	tissue pharmacokinetics intratumoral paclitaxel pharmacokinetics esophageal cancer ABCB1 Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/2da8bb17075a4bb7a21f579be94bb87f
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Tissue Type Differences in ABCB1 Expression and Paclitaxel Tissue Pharmacokinetics in Patients With Esophageal Cancer

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