Tissue Type Differences in ABCB1 Expression and Paclitaxel Tissue Pharmacokinetics in Patients With Esophageal Cancer

Tissue Type Differences in ABCB1 Expression and Paclitaxel Tissue Pharmacokinetics in Patients With Esophageal Cancer

Background: Data from previous work suggests that there is no correlation between systemic (plasma) paclitaxel exposure and efficacy in patients treated for esophageal cancer. In this trial, we investigated ATP-binding cassette efflux transporter expression and intratumoral pharmacokinetics of pacli...

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Main Authors: Ruben A. G. van Eerden, Leni van Doorn, Femke M. de Man, Niels Heersche, Michail Doukas, Thierry P. P. van den Bosch, Esther Oomen-de Hoop, Peter de Bruijn, Sander Bins, Eman Ibrahim, Suzan Nikkessen, Lena E. Friberg, Stijn L. W. Koolen, Manon C. W. Spaander, Ron H. J. Mathijssen
Format: article
Language:EN
Published: Frontiers Media S.A. 2021
Subjects:
tissue pharmacokinetics
intratumoral
paclitaxel
pharmacokinetics
esophageal cancer
ABCB1
Therapeutics. Pharmacology
RM1-950
Online Access:https://doaj.org/article/2da8bb17075a4bb7a21f579be94bb87f
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https://doaj.org/article/2da8bb17075a4bb7a21f579be94bb87f

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