Advancement of PD Is Reflected by White Matter Changes in Olfactory Areas: A Pilot Study

Loss of sense of smell is a well-known non-motor symptom of Parkinson’s disease (PD). Here, we present insight into the association between PD advancement and equivalents of smell loss in olfactory-eloquent brain areas, such as the posterior cortex and orbitofrontal cortex. Twelve PD patients in dif...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Thomas Hummel, Antje Haehner, Divesh Thaploo, Charalampos Georgiopoulos, Björn Falkenburger, Katherine Whitcroft
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	Parkinson’s disease diffusion tensor imaging left posterior piriform cortex orbitofrontal cortex Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/2daa16970184459e9d7218353d8df94b
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:2daa16970184459e9d7218353d8df94b
record_format	dspace
spelling	oai:doaj.org-article:2daa16970184459e9d7218353d8df94b2021-11-25T18:18:23ZAdvancement of PD Is Reflected by White Matter Changes in Olfactory Areas: A Pilot Study10.3390/medicina571111831648-91441010-660Xhttps://doaj.org/article/2daa16970184459e9d7218353d8df94b2021-11-01T00:00:00Zhttps://www.mdpi.com/1648-9144/57/11/1183https://doaj.org/toc/1010-660Xhttps://doaj.org/toc/1648-9144Loss of sense of smell is a well-known non-motor symptom of Parkinson’s disease (PD). Here, we present insight into the association between PD advancement and equivalents of smell loss in olfactory-eloquent brain areas, such as the posterior cortex and orbitofrontal cortex. Twelve PD patients in different Hoehn and Yahr stages and 12 healthy normosmic individuals were examined with diffusion tensor imaging. Tract-based spatial statistics were used to analyze microstructural changes in white matter adjacent to the bilateral posterior and orbitofrontal cortex. Axial diffusivity, mean diffusivity, and radial diffusivity were significantly higher in olfactory ROIs in advanced PD patients. The results of this preliminary study indicate that PD advancement is associated with progressive neurodegeneration in olfactory-related brain areas.Thomas HummelAntje HaehnerDivesh ThaplooCharalampos GeorgiopoulosBjörn FalkenburgerKatherine WhitcroftMDPI AGarticleParkinson’s diseasediffusion tensor imagingleft posterior piriform cortexorbitofrontal cortexMedicine (General)R5-920ENMedicina, Vol 57, Iss 1183, p 1183 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Parkinson’s disease diffusion tensor imaging left posterior piriform cortex orbitofrontal cortex Medicine (General) R5-920
spellingShingle	Parkinson’s disease diffusion tensor imaging left posterior piriform cortex orbitofrontal cortex Medicine (General) R5-920 Thomas Hummel Antje Haehner Divesh Thaploo Charalampos Georgiopoulos Björn Falkenburger Katherine Whitcroft Advancement of PD Is Reflected by White Matter Changes in Olfactory Areas: A Pilot Study
description	Loss of sense of smell is a well-known non-motor symptom of Parkinson’s disease (PD). Here, we present insight into the association between PD advancement and equivalents of smell loss in olfactory-eloquent brain areas, such as the posterior cortex and orbitofrontal cortex. Twelve PD patients in different Hoehn and Yahr stages and 12 healthy normosmic individuals were examined with diffusion tensor imaging. Tract-based spatial statistics were used to analyze microstructural changes in white matter adjacent to the bilateral posterior and orbitofrontal cortex. Axial diffusivity, mean diffusivity, and radial diffusivity were significantly higher in olfactory ROIs in advanced PD patients. The results of this preliminary study indicate that PD advancement is associated with progressive neurodegeneration in olfactory-related brain areas.
format	article
author	Thomas Hummel Antje Haehner Divesh Thaploo Charalampos Georgiopoulos Björn Falkenburger Katherine Whitcroft
author_facet	Thomas Hummel Antje Haehner Divesh Thaploo Charalampos Georgiopoulos Björn Falkenburger Katherine Whitcroft
author_sort	Thomas Hummel
title	Advancement of PD Is Reflected by White Matter Changes in Olfactory Areas: A Pilot Study
title_short	Advancement of PD Is Reflected by White Matter Changes in Olfactory Areas: A Pilot Study
title_full	Advancement of PD Is Reflected by White Matter Changes in Olfactory Areas: A Pilot Study
title_fullStr	Advancement of PD Is Reflected by White Matter Changes in Olfactory Areas: A Pilot Study
title_full_unstemmed	Advancement of PD Is Reflected by White Matter Changes in Olfactory Areas: A Pilot Study
title_sort	advancement of pd is reflected by white matter changes in olfactory areas: a pilot study
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/2daa16970184459e9d7218353d8df94b
work_keys_str_mv	AT thomashummel advancementofpdisreflectedbywhitematterchangesinolfactoryareasapilotstudy AT antjehaehner advancementofpdisreflectedbywhitematterchangesinolfactoryareasapilotstudy AT diveshthaploo advancementofpdisreflectedbywhitematterchangesinolfactoryareasapilotstudy AT charalamposgeorgiopoulos advancementofpdisreflectedbywhitematterchangesinolfactoryareasapilotstudy AT bjornfalkenburger advancementofpdisreflectedbywhitematterchangesinolfactoryareasapilotstudy AT katherinewhitcroft advancementofpdisreflectedbywhitematterchangesinolfactoryareasapilotstudy
_version_	1718411371062755328

Advancement of PD Is Reflected by White Matter Changes in Olfactory Areas: A Pilot Study

Ejemplares similares