LRIG proteins regulate lipid metabolism via BMP signaling and affect the risk of type 2 diabetes

Herdenberg et al. show that adipogenesis and BMP signaling are altered in mouse cells deficient in LRIG (Leucine-rich repeats and immunoglobulin-like domains) proteins. They find that mutant LRIG/sma-10 variant worms exhibit lipid storage defects and that human LRIG1 variants are associated with hig...

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Autores principales:	Carl Herdenberg, Pascal M. Mutie, Ola Billing, Ahmad Abdullah, Rona J. Strawbridge, Ingrid Dahlman, Simon Tuck, Camilla Holmlund, Peter Arner, Roger Henriksson, Paul W. Franks, Håkan Hedman
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/2dabfe4ef579463aa23b059fe23b8acc
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spelling	oai:doaj.org-article:2dabfe4ef579463aa23b059fe23b8acc2021-12-02T10:49:33ZLRIG proteins regulate lipid metabolism via BMP signaling and affect the risk of type 2 diabetes10.1038/s42003-020-01613-w2399-3642https://doaj.org/article/2dabfe4ef579463aa23b059fe23b8acc2021-01-01T00:00:00Zhttps://doi.org/10.1038/s42003-020-01613-whttps://doaj.org/toc/2399-3642Herdenberg et al. show that adipogenesis and BMP signaling are altered in mouse cells deficient in LRIG (Leucine-rich repeats and immunoglobulin-like domains) proteins. They find that mutant LRIG/sma-10 variant worms exhibit lipid storage defects and that human LRIG1 variants are associated with higher body mass index, yet protect against type 2 diabetes. This study suggests an evolutionarily conserved role of LRIG proteins for lipid metabolism and BMP signaling.Carl HerdenbergPascal M. MutieOla BillingAhmad AbdullahRona J. StrawbridgeIngrid DahlmanSimon TuckCamilla HolmlundPeter ArnerRoger HenrikssonPaul W. FranksHåkan HedmanNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Carl Herdenberg Pascal M. Mutie Ola Billing Ahmad Abdullah Rona J. Strawbridge Ingrid Dahlman Simon Tuck Camilla Holmlund Peter Arner Roger Henriksson Paul W. Franks Håkan Hedman LRIG proteins regulate lipid metabolism via BMP signaling and affect the risk of type 2 diabetes
description	Herdenberg et al. show that adipogenesis and BMP signaling are altered in mouse cells deficient in LRIG (Leucine-rich repeats and immunoglobulin-like domains) proteins. They find that mutant LRIG/sma-10 variant worms exhibit lipid storage defects and that human LRIG1 variants are associated with higher body mass index, yet protect against type 2 diabetes. This study suggests an evolutionarily conserved role of LRIG proteins for lipid metabolism and BMP signaling.
format	article
author	Carl Herdenberg Pascal M. Mutie Ola Billing Ahmad Abdullah Rona J. Strawbridge Ingrid Dahlman Simon Tuck Camilla Holmlund Peter Arner Roger Henriksson Paul W. Franks Håkan Hedman
author_facet	Carl Herdenberg Pascal M. Mutie Ola Billing Ahmad Abdullah Rona J. Strawbridge Ingrid Dahlman Simon Tuck Camilla Holmlund Peter Arner Roger Henriksson Paul W. Franks Håkan Hedman
author_sort	Carl Herdenberg
title	LRIG proteins regulate lipid metabolism via BMP signaling and affect the risk of type 2 diabetes
title_short	LRIG proteins regulate lipid metabolism via BMP signaling and affect the risk of type 2 diabetes
title_full	LRIG proteins regulate lipid metabolism via BMP signaling and affect the risk of type 2 diabetes
title_fullStr	LRIG proteins regulate lipid metabolism via BMP signaling and affect the risk of type 2 diabetes
title_full_unstemmed	LRIG proteins regulate lipid metabolism via BMP signaling and affect the risk of type 2 diabetes
title_sort	lrig proteins regulate lipid metabolism via bmp signaling and affect the risk of type 2 diabetes
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/2dabfe4ef579463aa23b059fe23b8acc
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LRIG proteins regulate lipid metabolism via BMP signaling and affect the risk of type 2 diabetes

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