Involvement of apoptosis in host-parasite interactions in the zebra mussel.

The question of whether cell death by apoptosis plays a biological function during infection is key to understanding host-parasite interactions. We investigated the involvement of apoptosis in several host-parasite systems, using zebra mussels Dreissena polymorpha as test organisms and their micro-...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Laëtitia Minguez, Nelly Brulé, Bénédicte Sohm, Simon Devin, Laure Giambérini
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2daee94bbbcf436cbe25e6fc555b4db8
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:2daee94bbbcf436cbe25e6fc555b4db8
record_format	dspace
spelling	oai:doaj.org-article:2daee94bbbcf436cbe25e6fc555b4db82021-11-18T07:41:53ZInvolvement of apoptosis in host-parasite interactions in the zebra mussel.1932-620310.1371/journal.pone.0065822https://doaj.org/article/2daee94bbbcf436cbe25e6fc555b4db82013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23785455/?tool=EBIhttps://doaj.org/toc/1932-6203The question of whether cell death by apoptosis plays a biological function during infection is key to understanding host-parasite interactions. We investigated the involvement of apoptosis in several host-parasite systems, using zebra mussels Dreissena polymorpha as test organisms and their micro- and macroparasites. As a stress response associated with parasitism, heat shock proteins (Hsp) can be induced. In this protein family, Hsp70 are known to be apoptosis inhibitors. Mussels were diagnosed for their respective infections by standard histological methods; apoptosis was detected using the TUNEL methods on paraffin sections and Hsp70 by immunohistochemistry on cryosections. Circulating hemocytes were the main cells observed in apoptosis whereas infected tissues displayed no or few apoptotic cells. Parasitism by intracellular bacteria Rickettsiales-like and the trematode Bucephalus polymorphus were associated with the inhibition of apoptosis whereas ciliates Ophryoglena spp. or the trematode Phyllodistomum folium did not involve significant differences in apoptosis. Even if some parasites were able to modulate apoptosis in zebra mussels, we did not see evidence of any involvement of Hsp70 on this mechanism.Laëtitia MinguezNelly BruléBénédicte SohmSimon DevinLaure GiambériniPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 6, p e65822 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Laëtitia Minguez Nelly Brulé Bénédicte Sohm Simon Devin Laure Giambérini Involvement of apoptosis in host-parasite interactions in the zebra mussel.
description	The question of whether cell death by apoptosis plays a biological function during infection is key to understanding host-parasite interactions. We investigated the involvement of apoptosis in several host-parasite systems, using zebra mussels Dreissena polymorpha as test organisms and their micro- and macroparasites. As a stress response associated with parasitism, heat shock proteins (Hsp) can be induced. In this protein family, Hsp70 are known to be apoptosis inhibitors. Mussels were diagnosed for their respective infections by standard histological methods; apoptosis was detected using the TUNEL methods on paraffin sections and Hsp70 by immunohistochemistry on cryosections. Circulating hemocytes were the main cells observed in apoptosis whereas infected tissues displayed no or few apoptotic cells. Parasitism by intracellular bacteria Rickettsiales-like and the trematode Bucephalus polymorphus were associated with the inhibition of apoptosis whereas ciliates Ophryoglena spp. or the trematode Phyllodistomum folium did not involve significant differences in apoptosis. Even if some parasites were able to modulate apoptosis in zebra mussels, we did not see evidence of any involvement of Hsp70 on this mechanism.
format	article
author	Laëtitia Minguez Nelly Brulé Bénédicte Sohm Simon Devin Laure Giambérini
author_facet	Laëtitia Minguez Nelly Brulé Bénédicte Sohm Simon Devin Laure Giambérini
author_sort	Laëtitia Minguez
title	Involvement of apoptosis in host-parasite interactions in the zebra mussel.
title_short	Involvement of apoptosis in host-parasite interactions in the zebra mussel.
title_full	Involvement of apoptosis in host-parasite interactions in the zebra mussel.
title_fullStr	Involvement of apoptosis in host-parasite interactions in the zebra mussel.
title_full_unstemmed	Involvement of apoptosis in host-parasite interactions in the zebra mussel.
title_sort	involvement of apoptosis in host-parasite interactions in the zebra mussel.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/2daee94bbbcf436cbe25e6fc555b4db8
work_keys_str_mv	AT laetitiaminguez involvementofapoptosisinhostparasiteinteractionsinthezebramussel AT nellybrule involvementofapoptosisinhostparasiteinteractionsinthezebramussel AT benedictesohm involvementofapoptosisinhostparasiteinteractionsinthezebramussel AT simondevin involvementofapoptosisinhostparasiteinteractionsinthezebramussel AT lauregiamberini involvementofapoptosisinhostparasiteinteractionsinthezebramussel
_version_	1718423088268312576

Involvement of apoptosis in host-parasite interactions in the zebra mussel.

Ejemplares similares