Turn-on Luminescent Probe for Hydrogen Peroxide Sensing and Imaging in Living Cells based on an Iridium(III) Complex–Silver Nanoparticle Platform

Abstract A sensitive turn-on luminescent sensor for H2O2 based on the silver nanoparticle (AgNP)-mediated quenching of an luminescent Ir(III) complex (Ir-1) has been designed. In the absence of H2O2, the luminescence intensity of Ir-1 can be quenched by AgNPs via non-radiative energy transfer. Howev...

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Autores principales:	Jinshui Liu, Zhen-Zhen Dong, Chao Yang, Guodong Li, Chun Wu, Fu-Wa Lee, Chung-Hang Leung, Dik-Lung Ma
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2db1255bf3e348ca978ee8ab631468d0
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spelling	oai:doaj.org-article:2db1255bf3e348ca978ee8ab631468d02021-12-02T11:52:26ZTurn-on Luminescent Probe for Hydrogen Peroxide Sensing and Imaging in Living Cells based on an Iridium(III) Complex–Silver Nanoparticle Platform10.1038/s41598-017-09478-62045-2322https://doaj.org/article/2db1255bf3e348ca978ee8ab631468d02017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-09478-6https://doaj.org/toc/2045-2322Abstract A sensitive turn-on luminescent sensor for H2O2 based on the silver nanoparticle (AgNP)-mediated quenching of an luminescent Ir(III) complex (Ir-1) has been designed. In the absence of H2O2, the luminescence intensity of Ir-1 can be quenched by AgNPs via non-radiative energy transfer. However, H2O2 can oxidize AgNPs to soluble Ag+ cations, which restores the luminescence of Ir-1. The sensing platform displayed a sensitive response to H2O2 in the range of 0−17 μM, with a detection limit of 0.3 μM. Importantly, the probe was successfully applied to monitor intracellular H2O2 in living cells, and it also showed high selectivity for H2O2 over other interfering substances.Jinshui LiuZhen-Zhen DongChao YangGuodong LiChun WuFu-Wa LeeChung-Hang LeungDik-Lung MaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-7 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jinshui Liu Zhen-Zhen Dong Chao Yang Guodong Li Chun Wu Fu-Wa Lee Chung-Hang Leung Dik-Lung Ma Turn-on Luminescent Probe for Hydrogen Peroxide Sensing and Imaging in Living Cells based on an Iridium(III) Complex–Silver Nanoparticle Platform
description	Abstract A sensitive turn-on luminescent sensor for H2O2 based on the silver nanoparticle (AgNP)-mediated quenching of an luminescent Ir(III) complex (Ir-1) has been designed. In the absence of H2O2, the luminescence intensity of Ir-1 can be quenched by AgNPs via non-radiative energy transfer. However, H2O2 can oxidize AgNPs to soluble Ag+ cations, which restores the luminescence of Ir-1. The sensing platform displayed a sensitive response to H2O2 in the range of 0−17 μM, with a detection limit of 0.3 μM. Importantly, the probe was successfully applied to monitor intracellular H2O2 in living cells, and it also showed high selectivity for H2O2 over other interfering substances.
format	article
author	Jinshui Liu Zhen-Zhen Dong Chao Yang Guodong Li Chun Wu Fu-Wa Lee Chung-Hang Leung Dik-Lung Ma
author_facet	Jinshui Liu Zhen-Zhen Dong Chao Yang Guodong Li Chun Wu Fu-Wa Lee Chung-Hang Leung Dik-Lung Ma
author_sort	Jinshui Liu
title	Turn-on Luminescent Probe for Hydrogen Peroxide Sensing and Imaging in Living Cells based on an Iridium(III) Complex–Silver Nanoparticle Platform
title_short	Turn-on Luminescent Probe for Hydrogen Peroxide Sensing and Imaging in Living Cells based on an Iridium(III) Complex–Silver Nanoparticle Platform
title_full	Turn-on Luminescent Probe for Hydrogen Peroxide Sensing and Imaging in Living Cells based on an Iridium(III) Complex–Silver Nanoparticle Platform
title_fullStr	Turn-on Luminescent Probe for Hydrogen Peroxide Sensing and Imaging in Living Cells based on an Iridium(III) Complex–Silver Nanoparticle Platform
title_full_unstemmed	Turn-on Luminescent Probe for Hydrogen Peroxide Sensing and Imaging in Living Cells based on an Iridium(III) Complex–Silver Nanoparticle Platform
title_sort	turn-on luminescent probe for hydrogen peroxide sensing and imaging in living cells based on an iridium(iii) complex–silver nanoparticle platform
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/2db1255bf3e348ca978ee8ab631468d0
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Turn-on Luminescent Probe for Hydrogen Peroxide Sensing and Imaging in Living Cells based on an Iridium(III) Complex–Silver Nanoparticle Platform

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