F-actin mechanics control spindle centring in the mouse zygote

How the mitotic spindle is positioned in the centre of the cell during the first mitotic division is not clear. Here Chaigne et al.show that the pronucleus coarsely centres using F-actin/Myosin-Vb dynamics, and the metaphase plate is finely centred by an F-actin cage influenced by high cortical tens...

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Autores principales: Agathe Chaigne, Clément Campillo, Raphaël Voituriez, Nir S. Gov, Cécile Sykes, Marie-Hélène Verlhac, Marie-Emilie Terret
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/2db63ef515514eb3964e8307e1af04d8
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