A DNA origami-based nanoscale molecular transport railway

Origami, the Japanese art of paper folding, has taken on new meaning for the fields of chemistry and biology. DNA origami describes the folding of DNA strands to form nanoscale structures. The ability to design and form complex structures at a nanoscale level has fuelled new ambitions of nanostructu...

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Autores principales:	Theam Soon Lim, Karli Montague-Cardoso
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/2db77ca452a1430b9a300fa9752a66db
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id	oai:doaj.org-article:2db77ca452a1430b9a300fa9752a66db
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spelling	oai:doaj.org-article:2db77ca452a1430b9a300fa9752a66db2021-12-02T17:19:12ZA DNA origami-based nanoscale molecular transport railway10.1038/s42003-021-02579-z2399-3642https://doaj.org/article/2db77ca452a1430b9a300fa9752a66db2021-09-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02579-zhttps://doaj.org/toc/2399-3642Origami, the Japanese art of paper folding, has taken on new meaning for the fields of chemistry and biology. DNA origami describes the folding of DNA strands to form nanoscale structures. The ability to design and form complex structures at a nanoscale level has fuelled new ambitions of nanostructure applications in life science. These predefined shapes become base structures for the development of a higher and complex functional structure. In a recent paper, Stömmer et al., demonstrated the ability to design a macromolecular level transportation network that allows the movement of molecules at sub-molecular levels using DNA. A multi-layer DNA origami was used to build micrometer-long hollow tunnels akin to railway tunnels. An accompanying DNA piston travelled through the tunnels with constant motion. The system also accommodated the application of electric fields to fuel the motion of the pistons along the filaments simulating a nanoscale electric railway system. This could revolutionize the way molecular drug delivery systems can be perceived in the future.Theam Soon LimKarli Montague-CardosoNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-2 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Theam Soon Lim Karli Montague-Cardoso A DNA origami-based nanoscale molecular transport railway
description	Origami, the Japanese art of paper folding, has taken on new meaning for the fields of chemistry and biology. DNA origami describes the folding of DNA strands to form nanoscale structures. The ability to design and form complex structures at a nanoscale level has fuelled new ambitions of nanostructure applications in life science. These predefined shapes become base structures for the development of a higher and complex functional structure. In a recent paper, Stömmer et al., demonstrated the ability to design a macromolecular level transportation network that allows the movement of molecules at sub-molecular levels using DNA. A multi-layer DNA origami was used to build micrometer-long hollow tunnels akin to railway tunnels. An accompanying DNA piston travelled through the tunnels with constant motion. The system also accommodated the application of electric fields to fuel the motion of the pistons along the filaments simulating a nanoscale electric railway system. This could revolutionize the way molecular drug delivery systems can be perceived in the future.
format	article
author	Theam Soon Lim Karli Montague-Cardoso
author_facet	Theam Soon Lim Karli Montague-Cardoso
author_sort	Theam Soon Lim
title	A DNA origami-based nanoscale molecular transport railway
title_short	A DNA origami-based nanoscale molecular transport railway
title_full	A DNA origami-based nanoscale molecular transport railway
title_fullStr	A DNA origami-based nanoscale molecular transport railway
title_full_unstemmed	A DNA origami-based nanoscale molecular transport railway
title_sort	dna origami-based nanoscale molecular transport railway
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/2db77ca452a1430b9a300fa9752a66db
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A DNA origami-based nanoscale molecular transport railway

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